In a desperate bid to slay Francis Dolarhyde, Will Graham engineers a cunning ploy utilizing Hannibal Lecter. Upon learning of his plan, Bedelia Du Maurier voices concerns that Will's actions may not only put his life in peril, but the lives of those around him. As the end draws near, Will remains unflinching in his game with Hannibal-even when it means coming face-to-face with his own darkest fears?

Captured in Italy by police on Mason Verger's payroll, Will Graham and Hannibal Lecter are delivered to Muskrat Farm to await Mason's revenge. Alana, distressed that Will has been endangered along with Hannibal, plots a rescue. And Hannibal, once again in contact with his old patient Margot, finds it irresistible to remind her that Mason will never make good on his promises. Meanwhile, Jack informs Chiyo of Hannibal's location.

Springing their trap, Jack, Will and Alana face off with Hannibal in a bloody final showdown, but the doctor has a few surprises of his own.

The hunt for Hannibal begins. Will travels via train with Chiyoh to Florence, as Alanna and Mason use Hannibal's fine tastes to track his whereabouts. Pazzi tries to get in close to find out if Hannibal is the man he's looking for, but his greed may get the better of him.

Will Graham and the FBI enlist the expertise of Dr. Fredrick Chilton in the hopes of luring Francis Dolarhyde into an ambush, using Freddie Lounds as their mouthpiece. As Will's empathy for Dolarhyde begins to affect his fragile psyche, Bedelia Du Maurier warns that the killer Will should be most concerned about at the moment is himself. Meanwhile, Dolarhyde senses that the FBI is closing in and launches a horrifying endgame.

The BSU investigates Beverly's death after her body is found displayed in a gruesome tableau. Abel Gideon returns to the Baltimore Hospital for the Criminally Insane. Will seeks a horrific revenge for Beverly's death.

As Miriam Lass begins her recovery, Will is released from prison and resumes his pursuit of Hannibal.

With Bedelia securing her alibi, Hannibal prepares to leave Florence just as Jack and Will begin to track him down. With Pazzi murdered, Mason and his cohorts consider a different course of action. However, Chiyoh has arrived in Florence with her own agenda.

Emboldened after drug therapy from Dr. Chilton, Will sets a deadly plan in place to expose Hannibal. A new killer is turning victims into beehives.

Hannibal frames Will, convincing Jack and Alana that Will's the copycat killer.

With Will Graham in prison, the FBI investigates his claims against Hannibal. A new serial killer emerges.

As Will's murder trial begins, a copycat killer sends a gruesome message. Jack is under pressure to wrap up Will's case while Hannibal hopes for his friend's exoneration.

Jack suspects Hannibal might be the Chesapeake Ripper as two more victims turn up. Hannibal and Alana distance themselves from Will.

Will and Margot hide her pregnancy from Mason. After Freddie's gruesome murder, Alana's doubts about Will and Hannibal grow stronger.

Dr. Hannibal Lecter has been under lock and key for three years at the Baltimore State Hospital for the Criminally Insane, when a new villain arises in Francis Dolarhyde, also known as "The Tooth Fairy." As the investigation unfolds Jack Crawford approaches Will Graham to help catch this vicious serial killer who is targeting families.

Convinced that the Red Dragon will strike at the next full moon, Jack and Will grow desperate, and Alana turns to Hannibal for help.

A deadly symphony hall killing forces Will to hunt a defiant killer.

Carvings symbolizing the Great Red Dragon, retrieved from crime scenes, help Will Graham and the FBI shed light on Francis Dolarhyde's disturbing psychology. Meanwhile, Dolarhyde finds ways to communicate directly with Hannibal Lecter regarding his "becoming." Will feels his bond with Hannibal growing uncomfortably stronger, and seeks out Bedelia Du Maurier, the only other person who fully understands the complexities of such a relationship.

Hannibal convinces Jack and Alana that Will could be the copycat killer.

Will's readiness to go to dark places strengthens his bond with Hannibal.

Bedelia returns and accepts immunity to testify against Hannibal. Mason Verger plots revenge after learning of Hannibal's manipulations.

Will races to stop a rogue surgeon extracting organs from his victims.

As the FBI seeks Will's help in tracking a killer who turns his victims' bodies into art, Will plots to reveal the truth about Hannibal.

The FBI's search for elusive serial killer Francis Dolarhyde intensifies as Will Graham begins envisioning himself in Dolarhyde's tormented psyche. Wading deeper into dangerous territory, Will enlists the help of Hannibal Lecter to assist with the killer's profile. Meanwhile, Alana Bloom reminds Will that the last time that he and Hannibal worked together things didn't end well, but Will sees no other option. Elsewhere, a new woman comes into Dolarhyde's life.

Margot Verger seeks out Will as she tries to understand Hannibal. The FBI searches for an animalistic killer who tears his victims' bodies apart.