A series of family murders takes place.

After surviving a disfiguring gunshot, Dr. Fredrick Chilton is now focused on rallying support to capture Hannibal, using Will as bait. Jack is distracted by Bella's failing health, but he implores Will to abandon the risky idea of finding Hannibal. Meanwhile, Alana Bloom entertains a different approach, potentially partnering with Mason Verger to utilize his vast resources.

Jack and Will search for a killer who turns his victims into angels.

With his wounds now healed, Will Graham heads to Europe eight months after the horrific event that almost took his life, in search of closure with Hannibal Lecter. Meanwhile an Italian inspector thinks that Lecter and a killer he pursued 20 years earlier are the same person.

Will Graham continues his search for Hannibal Lecter, making his way to Hannibal's childhood home in Lithuania. Meanwhile, Jack Crawford arrives in Italy, hoping to find Will and intervene before tragedy strikes again, and Bedelia warns Hannibal against unraveling his new life.

Will and Jack race to apprehend a serial killer using humans as fertilizer.

Abigail Hobbs comes out of her coma with new information about her father.

After the devastating bloodbath at Lecters home Hannibal establishes a new life for himself in Italy along with the company of his own psychiatrist Bedelia.

Will, Jack and the BAU team hunt for a serial killer who creates a totem pole out of his victims' bodies.

The FBI's search for elusive serial killer Francis Dolarhyde intensifies as Will Graham begins envisioning himself in Dolarhyde's tormented psyche. Wading deeper into dangerous territory, Will enlists the help of Hannibal Lecter to assist with the killer's profile. Meanwhile, Alana Bloom reminds Will that the last time that he and Hannibal worked together things didn't end well, but Will sees no other option. Elsewhere, a new woman comes into Dolarhyde's life.

When the FBI takes on a case of disappearing college girls, Jack Crawford recruits Will Graham, a gifted criminal profiler with a unique view into the psyche of serial killers, to consult. Jack also seeks the help of Dr. Hannibal Lecter, a brilliant psychiatrist. After a copycat strikes, Will and Hannibal join forces to track down the culprit.

Will resumes his therapy with Dr. Lecter. The FBI investigates the murder of a woman whose body was found sewn inside a dead horse.

Carvings symbolizing the Great Red Dragon, retrieved from crime scenes, help Will Graham and the FBI shed light on Francis Dolarhyde's disturbing psychology. Meanwhile, Dolarhyde finds ways to communicate directly with Hannibal Lecter regarding his "becoming." Will feels his bond with Hannibal growing uncomfortably stronger, and seeks out Bedelia Du Maurier, the only other person who fully understands the complexities of such a relationship.

The Chesapeake Ripper taunts Jack Crawford with guilt from the past.

When Dr. Gideon escapes to terrorize Alana and Dr. Chilton, Hannibal and Will go on the hunt. Eddie Izzard guest stars.

Margot Verger seeks out Will as she tries to understand Hannibal. The FBI searches for an animalistic killer who tears his victims' bodies apart.

Dr. Hannibal Lecter has been under lock and key for three years at the Baltimore State Hospital for the Criminally Insane, when a new villain arises in Francis Dolarhyde, also known as "The Tooth Fairy." As the investigation unfolds Jack Crawford approaches Will Graham to help catch this vicious serial killer who is targeting families.

Convinced that the Red Dragon will strike at the next full moon, Jack and Will grow desperate, and Alana turns to Hannibal for help.

Will races to stop a rogue surgeon extracting organs from his victims.

As Will's murder trial begins, a copycat killer sends a gruesome message. Jack is under pressure to wrap up Will's case while Hannibal hopes for his friend's exoneration.

Will tracks a killer with mental instability similar to his own.

With Bedelia securing her alibi, Hannibal prepares to leave Florence just as Jack and Will begin to track him down. With Pazzi murdered, Mason and his cohorts consider a different course of action. However, Chiyoh has arrived in Florence with her own agenda.

Hannibal convinces Jack and Alana that Will could be the copycat killer.

With Will Graham in prison, the FBI investigates his claims against Hannibal. A new serial killer emerges.

Will's readiness to go to dark places strengthens his bond with Hannibal.