Alex and Pierce are at odds about whether the hospital should provide an experimental treatment for patients with advanced-stage cancer. In other events, Max wants to change the family dynamic with Alex and Ji Sung connects with Callahan.

A patient questions Alex's ability to leave personal grief outside the OR when she performs heart surgery on the anniversary of her sister's death; Millicent dates an artist; Pierce wants to be more of a part of Alex's family.

A case brings back memories for Alex, Jesse and Millicent as they fight to save a heart transplant patient when she sustains devastating injuries in a car crash.

Alex (Melissa George) and Jesse (Don Hany) put the hospital's reputation on the line while trying to fulfill the dying wish of a young heart patient.

Alex and Ji-Sung fight to save the life of a transgender woman with breast cancer; a consultant from another hospital forces Jesse to confront her feelings for Alex.

In the Season 1 finale, a mysterious illness sends the hospital into lockdown; and leaves Alex fighting to save the lives of Jesse, Pierce and Ji-Sung. In other events, Millicent deals with the consequences when Alex disobeys the CDC; and an elderly man's search for his missing wife causes Alex to make a major decision about her love life.

An ethical debate begins after Alex suggests performing some risky surgery on conjoined twins that have been diagnosed with cancer.

A new patient who is in critical need of a heart transplanthas to rely on Dr. Panttiere and the unconventional methods she uses.

When Alex's father needs a new kidney, an unlikely donor emerges and family secrets threaten to destroy the close relationship between father and daughter.

Alex sees a young man who is only able to recite sentences backward as a chance to try out some new technology.