Devon grows concerned when a mother's complaints go unaddressed after her delivery, and pushes Bell to take drastic measures. Conrad is faced with breaking the news to Nic regarding Jessie's worsening condition. Meanwhile, The Raptor, Mina and Kit spring into action when a mother and son enter the ER with devastating injuries.

In a final and drastic attempt to save Nic from Lane's acts of sabotage, Conrad must call in a favor from the one person he promised he never would. Meanwhile, Mina's partnership with The Raptor takes on new colors when Micah is rushed back to Chastain with major heart complications and Dr. Bell's alliance with Lane is put to the ultimate test when one of her patients is readmitted.

The surgeons work together to save the life of the Raptor's old mentor, Abe, who is their only inside source to Quovadis. Unfortunately, when Nic and Conrad take on a patient needing the hospital's only viable ECMO machine, they must decide between saving the life of Abe or saving the life of their younger, more stable patient. Meanwhile, Marshall puts himself in serious danger to help take down Gordon Page once and for all.

When things from Billie's past begin to come to light, she is the subject of whispers and stares around the hospital and the team struggles to find the best way to support her. With the nurse shortage in full swing, a simple cleaning job turns into a horrific disaster that calls for all hands on deck. Meanwhile, Trevor discovers a shocking secret and Padma has a proposal for Leela

Conrad is pulled away from celebrating Gigi’s 6th birthday when Sammie comes into Chastian with a 104-degree fever, and Kit must call in a favor for treatment. Meanwhile, a heart arrives for Governor Betz’s transplant surgery.

Devon's doubts about his relationship reach a peak as his friends and family gather for his big wedding day. As Chastain's leading medical device company, Quovadis, continues to succeed, Julian makes a discovery that leaves her uneasy about her involvement in it all. Meanwhile, Conrad continues to work on his relationship with Marshall and Bell takes a risky offer in order to make a mistake from his past disappear.

When an accident brings a familiar patient into the Chastain ER, the doctors must face the reality of figuring out how to proceed with the best care, which leads the whole staff questioning every decision. Meanwhile, The Raptor and Leela deal with a patient returning with the long-term effects of COVID.

Conrad, Kit, Mina and the Raptor work to save the life of a med student in need of a triple-organ transplant, drawing Bell back to the OR for one of the Chastain's riskiest surgeries yet. After the police find Julian's empty car in a nearby lake, Devon does some investigating of his own to find out what might have happened. Meanwhile, Mina and the Raptor hound Bell to halt his business with the risky medical device company, Quovadis, and Nic makes a rash decision regarding her sister.

The doctors work to save one of their own but disagree over what's best for her. Bell is met with an unexpected response when he voices concerns regarding the nursing shortage that Nic brought to his attention.

Devon and Conrad face a moral dilemma over a suicidal patient who is in need of a liver transplant.

With Chastain on the verge of shutting down due to the sale by Red Rock, Conrad tries a last-ditch effort to save the hospital and the doctors plan for their next career moves. Meanwhile, on their last day, the whole staff must work together to save Nic's life after she is injured by a deranged patient.

When Bell makes the executive call to utilize Julian Booth's medical devices, rather than the hospital's usual products, Kit and AJ must stop their momentary feuding in order to team up against him. Elsewhere in the hospital, Conrad and Nic work to make a child's dreams come true after finding out his cancer has returned and the rest of the staff takes notice of Julian and Devon's new friendship.

Lane Hunter's victims and their families become outraged when she is released from prison. Bell, although responsible for posting Lane's bail and getting her released, continues to be tortured by her manipulation. Meanwhile, Conrad uses work to cope with the news about his father, and he teams up with Mina, Kit and the Raptor to treat a patient who is suffering as a result of Lane's dangerous treatments. Then, Devon grows worried when he doesn't hear from Julian, and Nic sets her sights on a primary physician for their new clinic.

Conrad comes under fire when a former patient files a malpractice lawsuit against him, putting Bell in a difficult position with Red Rock. The doctors perform a risky brain surgery. Mina discovers that Adaku has a dangerous heart condition.

Conrad meets with a high-profile soccer player suffering from mysterious symptoms. Nic springs into action when she notices Kyle falling into a deep depression and fears he could be suicidal. Devon butts heads with Irving over patient space.

Cain recruits Ezra to help keep an emergency situation under wraps. Nic works to come up with a support system for a patient in need of a lung transplant. Kit's son-in-law's condition continues to worsen.

Conrad's ex-fiancé, Catherine, is admitted to the hospital with abdominal pain that proves to be quite the medical mystery. As Conrad doggedly tries to figure out her diagnosis and fights the idea of Bell performing her operation, Nic gets some insight into Conrad's past. Meanwhile, Bell panics when Claire announces that she will be installing cameras in all operating rooms, Devon wracks his brain for the perfect birthday present for Priya and Lane realizes that Nic is suspicious about her clinic.

Conrad and Devon work tirelessly to save the life of Bradley, a fellow doctor who has fallen through the hospital skylight. As the team contemplates how and why he fell through in the first place, Dr. Bell looks back to when he benched Bradley for falling asleep during surgery. Amidst the madness, Mina is tasked with showing Chastain's new star cardiothoracic surgeon, Dr. AJ Austin, around the hospital, but is caught off-guard by his volatile personality. Meanwhile, Nic finds renewed enthusiasm when she uncovers an oncologist who used to work with Lane, but while paying him a visit, she fears that she's being followed.

A blackout at Chastain Memorial Hospital requires the staff to treat their patients without the help of any technology. Bell orders the staff to stop accepting new patients and transfer those on life support, but when a child in need is rushed to the ER, Conrad and Devon go against the mandate. Meanwhile, Mina and Austin are tasked with performing heart surgery on a premature baby, despite the lack of power, and Nic works tirelessly to organize the staff and patients who stay during the blackout.

Bell's confidence in Quovadis continues to waver when the poster child for one of its medical devices, Henry Barnett, is rushed back into the ER, experiencing seizure-like symptoms. Meanwhile, Mina's past comes to light when her mother, famous Nigerian surgeon Dr. Okeke, pays a visit to Chastain, and Conrad makes a risky move when Henry returns to the hospital.

The surgeons are determined to shut down Quovadis after Henry Barnett almost loses his life due to a device malfunction. As Mina and Devon set out to find the truth, Bell, AJ and Conrad work to save the life of Chastain's favorite custodian, Simon. Meanwhile, one of Alec's old patients ends up in the ER, forcing him to question if he made the right choice to leave his old practice for Nic's clinic.

In an effort to save Chastain, Bell considers selling the hospital to a conglomerate, but Kit tries to make him see that the negatives will outweigh the positives. With Conrad's help, Nic tracks down Kyle and pleads for him to reconsider donating a kidney to Jessie. Meanwhile, Mina voices her concern to Austin when Shira is assigned to Micah's surgery and Devon fights for the care of a patient whom the doctors suspect is uninsured.

Just when Mina and The Raptor can see their future together, an unexpected complication throws a wrench in their plans. Meanwhile, Cain faces a harsh reality when Kit gives him the opportunity to prove he is ready to return to the OR. Then, Devon presents Rose with a groundbreaking clinical trial that could help her battle with Sickle Cell Anemia.

A case turns personal for Conrad when the donor recipient of Nic's heart is admitted to the ER. Bell is faced with a devastating diagnosis that causes him to make a heartbreaking decision. Meanwhile, the Raptor asks Devon to include his ailing mother in his clinical trial, causing Devon to face a major dilemma

With Raptor on leave to take care of his mother, the hospital scrambles to stay organized without him. Meanwhile, a camping trip leaves a patient with a fatal disease that none of the doctors have seen before. Then, Bell and Kit devise a plan to help their case with the Medical Board.