Grandpa accidentally feeds Heathcliff some Super doggy Vitamins. Gradually, Heathcliff undergoes a startling transformation which includes barking at trucks and passing up fish in favor of bones. Worst of all, he finds himself feeling friendly toward Spike. Heathcliff eventually sets things straight by taking a massive dose of cat vitamins, with Iggy's help.

There's a new arrival in the neighborhood. A highbrow English couple, and their equally-arched cat - Reginald.

Heathcliff and Iggy go to visit the zoo so that Heathcliff can finally meet the king of the beasts, the lion. But to Heathcliff's dismay, the lion is a kind-hearted and gentle creature and not at all to Heathcliff's liking. The apes in the zoo make fun of the lion because he is so tame. Heathcliff gives the cowardly lion some pointers on being fierce and strong which helps the lion put those nasty apes in their place!

Riff Raff enlists the Catillac Cats to aid his attempt to break into a bird sanctuary. After trying everything from a hang-glider to a trampoline, Riff Raff manages to gain entry, only to be bludgeoned by a giant feathered bouncer.

The cats put a new engine into the Catillac not realizing it is a time machine engine of Professor Craziloon. Before they know it they're back in the old West. After a few close calls with some rough and tough characters and a wild stagecoach chase in pursuit of their stolen caddy, they get the car back in the nick of time to be transported back to the future.

The Catillac Cats throw a birthday party for Leroy and they reminisce about how they all first met.

Hector complains about Riff Raff's leadership of the Catillac Cats, so Riff Raff offers to let him take over. After a series of dumb decisions and blatant bungles, even Hector has to agree there is no leader for the gang except Riff Raff.

Heathcliff hears through the grapevine that an over-friendly and slightly dim-witted canine friend of his named Chauncey has been captured by the dogcatcher in the next town. Heathcliff decides that Chauncey isn't all that bad and tries to spring him from the pound.

Riff Raff takes Cleo to a carnival after hours but their fun is thwarted by Bruno, Geldorf and a carnie.

The Nutmegs tour the fire station and are very embarrassed by Heathcliff's behavior. That night, while sleepwalking, Grandpa Nutmeg sets the house on fire and Heathcliff saves everyone by getting the firemen there in time, thus redeeming himself for the way he'd acted earlier.

Cleo wants a new bed, so she sends Riff Raff on a mission to find one. Meanwhile, Leroy's cousin Mervin McMutt is in town and using the bedding that Riff Raff needs...

Cousin Lucky comes to visit Riff Raff seeking help. It seems everywhere he goes, disaster follows, and his reputation as a jinx is so widespread, everyone runs when they see him coming. Riff Raff gives Lucky a good luck charm, and it really seems to work! However, Lucky becomes overconfident, discards the charm, and once again it rains only on him wherever he goes.

Mungo looks into the garbage can in Screwloose's painting and literally falls into the painting. Not realizing this, Hector adds a lid to the can trapping Mungo inside....

Spike's cousin, Bull, is a ferocious looking guard dog who sports a bone out of his mouth the way a tough guy might use a cigar. He convinces Spike that he no longer should take guff from Heathcliff and proceeds to teach him to defend himself but to no avail. After Bull has harassed everyone in the neighborhood, he challenges Heathcliff to a fight in the vacant lot on Elm Street and guess who wins? Who else, Heathcliff!

During an afternoon of deep-sea fishing, Heathcliff and the Nutmegs land their boat on a small island for a picnic and soon learn the island is inhabited by a tribe of wild cats called Meow Meows. These savages capture the Nutmegs, but Heathcliff cleverly rescues them from being sacrificed in a native ritual.

Riff Raff and Cleo decide to go steady. When a new girl comes to town, Riff Raff decides to juggle both. Cleo finds out and decides to sabotage Riff Raff's date.

J.B. is a rich, snobbish cat who comes to visit the Nutmegs. He expects Heathcliff to wait on him paw and paw, and even vies for Sonja's attention. However, Heathcliff discovers the dark secret of J.B.'s past and uses the information to his advantage.

Heathcliff becomes curious about his lineage and dreams about what his ancestors might have been like. We follow the escapades of historical Heathcliff in the Wild West, merry old England, and ancient Rome until Iggy calls to his cat and wakes him up.

Bush is about to lose his night job as a night guard of the candy factory because somebody keeps stealing chocolate. Riff Raff offers to help catch the crooks, which he does with the help of his friends.

Riff Raff's brother comes to visit and gets into trouble with the junkyard dog Leroy.

While on a camping trip with the Nutmegs, Heathcliff gets himself covered in feathers and sardine oil. A mountain lion and an eagle mistake Heathcliff for a bird, and fight over him. Eventually he escapes and returns safely home.

Heathcliff spreads false news around the neighborhood after hearing the city plans on trimming the trees.

Riff Raff, Cleo, and the Cats visit the world famous "Dizzyland" amusement park where they tour the House of the Future. The cats hide when the house closes for the day, and spend the evening enjoying all the comfort and gadgets the future holds.

Cleo's owners are going on vacation and plan to put her in a kennel, so Riff Raff and the Catillac Cats decide to rescue her. They break into the kennel and rescue Cleo, but not until they completely demolish the building in their attempt.

When Cleo visits her cousin, LuluBelle, in the country and takes the Catillac Cats along, it's love at first sight for Mungo and LuluBelle. But the amorous boy-next-door, Orville, already has designs on LuluBelle and will stop at nothing to keep his new competition from edging in.