After an elderly couple inadvertently help a murderous bank robber slip through a police road block, a restaurant manager spots the fugitive who uses the old folks to keep from getting caught.

Jerry Watts is the son of a millionaire and he's just been kidnapped and taken to an old shack high in the mountains. After a tip from a game warden brings the Highway Patrol, Jerry tries to escape to the officers, only to fall into a canyon severely injuring himself. The only way out is straight up.

Steve Talbot is a jewel thief who likes nice automobiles, and the Highway Patrol knows this. So Talbot flees capture after a job in an old junker. This gets him past the roadblocks but he soon is stranded on the side of the road. He hijacks a newly married couple pulling a trailer and Dan passes the trio through, not wanting harm to come to the civilians. But in passing the blockade, they unknowingly pick up a new rider.

A car that was involved in an accident is stolen and later found again, and just happens to match the description of one used in a bank holdup. Putting two and two together, Dan speculates that this was the getaway car and it's occupants must have escaped on foot, which is near a posh resort.

Reporter Sam Dalquist has gone missing. Dan has been looking for him because a two bit hood was found dead after getting a traffic citation driving Dalquist's car. The only lead Mathews has is that Dalquist was working on an exposé about a hood named Matlock and that may be where the writer will be found...dead or alive.

Hank Dooley's daughter has just died from typhoid fever, and Dooley is now searching for his farm hand Len Frazier who is the one who infected her, complete with rifle in hand.

Dan enlists the help of the leader of a local hot rod car club to assist in finding two robbers who use a souped-up car to get away from the Highway Patrol after each job.

Several criminals conspire to stage highway accidents prompting truck drivers to stop and help victims only to be assaulted and have their cargoes stolen. After discovering the hijackers are being tipped off by the owner of a roadside diner favored by truckers, Chief Mathews creates a ruse to force the crime ring into action with the hopes of capturing them.

An Army bazooka is stolen by two men who use it to capture the payroll from an oil drilling company.

The life of an ex-con is never easy, especially when cellmates show up expecting favors. Al Baldwin is a reformed criminal but suddenly has unexpected guests who hide out at his house while plotting their next crime. When that holdup goes bad, the cons hold Al's wife hostage until Dan and the Highway Patrol come to the rescue.

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A woman suspects her husband is trying to kill her. Iris: Virginia Dale. George: Douglas Henderson. Mathews: Broderick Crawford. Ted: Robert Cavendish.

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Mathews tries to prove the guilt of three holdup men---before the statute of limitations runs out. Mathews: Broderick Crawford. Eddie: Bing Russell. Wyatt: Mike Regan.

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Mathews and the Highway Patrol investigate a rash of forged payroll-check cashings affecting merchants in and around Los Angeles.

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