A woman who collects bottles of human waste; another woman who hoards items in preparation for the end of the world.

Manual was living in his hoarded house with his four children, ages 5, 6, 7, and 9. They are the love of his life, but they were removed by Child Protective Services and Manual won't get them back unless he cleans his act up. Meanwhile, Carla has had three failed marriages to men who cheated on her. As if to represent each husband, Carla has hoarded out three homes. Her family is trying to get her to at least clean out one of the houses so she can make a new start in life.

A daughter develops post-traumatic stress disorder because of her mom’s hoarding; a shopping addict loses custody of her son.

A woman who lives in a million-dollar neighborhood sifts through trash bins; authorities warn a couple that they must clean their cobweb-infested, filthy home.

A woman's hoarding carries over into her daughter's home; a hoarder buys back some items he sells.

Robin's home is so full of garbage that people in the street can smell the stench. With the city condemning the property and threatening to tear it down at their expense, Robin and her father must clean up their house to save it.

When Lia was ten, she became intrigued by her mother's many collectibles and started going to antique stores and estate sales with her and is where Lia suspects her hoarding compulsion originates. Unfortunately, Lia's hoarding went into overdrive when her three sons moved out, and Lia's husband, Ken, worked full time. After a severe blood infection and struggling with the emergency ambulance response, Lia realizes the extreme danger her home presents to her. Now with the help of the Hoarders team of experts, either Lia will clean up her home and have a safe place to live or risk everything.

A couple in Louisville, Kentucky who both suffer from hoarding risk losing their children if they don't comply with numerous citations given to them by the city. A woman's food hoarding in Milwaukee, Wisconsin is so bad that she places herself at risk for food poisoning.

Linda's husband could no longer stand the compulsive hoarding that filled the house they owned together. However, Linda must now sell her home as part of the settlement and it is sure to be an elaborate and anxiety-provoking process. Steven is at risk of eviction with a very poorly kept government-run housing. He may end up homeless again if he cannot clean up his house.

Adult Protective Services removed an elderly Marysville, Ohio woman's sick alcoholic husband from their home because of the hazardous conditions. The family's financial problems are complicated by their schizophrenic daughter, who is also a hoarder. A Torrance, CA woman who is an obsessive collector faces eviction if she fails to clean up her home.

A young man in Novato, California, who also suffers from obsessive-compulsive disorder, hoards garbage (snack wrappers, empty bottles, and rotting food) in a two-bedroom townhouse he shares with his alcoholic father. A blind woman's hoard in New Mexico is so bad that every room of her home is cluttered with over 75 living and dead cats, cat feces, and urine soaked carpets and furniture.

A Seattle, Washington couple are facing imminent foreclosure on two houses as a result of a decision to buy a second home to solve the wife's lifelong hoarding problem. A Charlottesville, Virginia woman's relationship with her boyfriend is in danger as a result of her hoard, which has taken over their entire townhouse.

A Kansas woman's compulsive shopping habits have taken over the entire house. Her children were removed by authorities as a result of the living conditions. A Beverly, Massachusetts man's hoard of both home renovation supplies and outdated materials is so bad that his common-law wife broke her arm tripping over a pile of his things. After seeming unfazed over the accident, he is given an ultimatum to clean up or move out.

Paul was charged with criminal littering in 2008 and has failed to meet three court ordered deadlines to clean his yard. His 2 acre property is strewn with over 70 junk cars, thousands of pounds of scrap metal, and hundreds of old appliances. In January, a judge sentenced him to 5 days in jail and gave him a few months to clean his property, or face a fine and additional jail time. Just days before the deadline Paul must make a decision; allow the tow trucks and metal collectors to descend on his property and clear out his collection, or go to jail. Missy is a hoarder with a 7 year old son, Alex, who has begun to exhibit hoarding tendencies. On several occasions when she has tried to clean, her son has cried hysterically over things like a rusty chain and an old used cotton ball. Unless she can set an example, Alex will continue to follow her behavior and may never have a shot at a normal life. Now Missy must clean up her house in order to save her son.

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Her son, Jason, has already been removed from her home. Augustine was never able to actually have him return to the house. Augustine now lives without water, gas, heat, or appliances and the courts have become involved forcing her to clean up.

Time is running out for Judi, whose cluttered home has been condemned; Gail was once a disciplined ballerina, but now her house is full of possessions and critters.

After her newborn son dies, Chris tries to fill the void with possessions that jeopardize custody of her daughters; Dale is at risk of eviction from his city-subsidized apartment filled with found objects for art projects.

The parents of four children must clean out their entire house or risk losing everything; a retired veterinarian's dozens of costly collections have come at the expense of his marriage and lifestyle.

A series of tragedies triggers hoarding that leads to a woman losing custody of her son to her ex-husband; Child Protective Services arrives with police at a couple's squalid home to remove their four children.

Deborah is a 49 year old mother of two who fears that her hoarding may cause her two children to be taken away. Her husband Ron claims that Deborah's hoarding triggered his depression and alcoholism and Deborah claims that Ron's alcoholism fueled her hoarding. The situation went from bad to worse when Ron attempted suicide seven years ago. Now Deborah must either change or risk losing her family. Jim is living a double life. He manages a successful honey business as a bee keeper but at home he lives as a compulsive hoarder. His 37 year old daughter Heather has threatened to call Adult Protective Services on him if he doesn't change for the sake of himself and his eight month old granddaughter.

Linda's family has been torn apart by her hoarding. She wants a relationship with her grown children but they refuse to visit her because Linda's house is piled up with belongings. Despite Linda's threat to commit suicide her family has given her an ultimatum to either clean up or her husband Shelton will divorce her and her children will choose not to remain in touch her any longer. 29 year old Todd has been collecting models, kits and several other hobby items ever since her was a kid. His girlfriend of five years Robyn wants to get married and to start a family but she has threatened to leave Todd if doesn't control his behaviors. Todd wants to create a life with her as well but he doesn't know where to begin.

Janet's life took a tragic turn for the worse when her husband of 32 years died while waiting for a heart transplant and since then her hoarding has spun out of control. She shops compulsively and has filled her home with home decorating supplies in hopes of redecorating the house she and her husband were planning on doing before he died. Christina is a former psychologist who is literally suffocating beneath her things. She is now breathing at about 80% due to chronic asthma and times she has be rendered blue due to exhaustion. She has filled her home with clothes for twelve year old daughter Hanna but even though most of the clothing has been unworn for years, Christina refuses to part with it. She now must clean up before her asthma gets any worse

Gail's house is literally falling apart. She is living without heat, the walls in her house are cracking, the ceiling is leaking and the floor boards are bowing. She has to make repairs but she needs to clean out her house in order to do so. Complicating the issue is that Gail is scheduled to have major surgery in two weeks and unless she cleans up she will have no where to go to recover from her surgery. Warren is a self-employed heating and refridgeration specialist who ends up taking his work home with him. Old refridgerators, tools and supplies clutter his house creating an unsafe environment for his three year old son Josh and his wife Leanne worries about her son's development. She has now given Warren an ultimatum to either clean up or move out.

A firefighter's co-workers worry his hoarding is affecting his job performance; a woman's two sons suffer due to her unkempt home.