When Lia was ten, she became intrigued by her mother's many collectibles and started going to antique stores and estate sales with her and is where Lia suspects her hoarding compulsion originates. Unfortunately, Lia's hoarding went into overdrive when her three sons moved out, and Lia's husband, Ken, worked full time. After a severe blood infection and struggling with the emergency ambulance response, Lia realizes the extreme danger her home presents to her. Now with the help of the Hoarders team of experts, either Lia will clean up her home and have a safe place to live or risk everything.

Andy has worked odd jobs his entire adult life, and he considers himself an entrepreneur specializing in the reselling of scrap and junk. After Andy’s father passed away in 2001, Andy’s mother, Louise, asked Andy to come live with her. Reselling scrap junk became very hard as the market for scrap metal pays much less and so Andy had talked his mother into getting a reverse mortgage on the property which has led to debt due to interest and fees. If the mortgage company came for an inspection, they could determine an unresolvable fault in payment and then take the house from Andy and his mother, leaving them homeless. Now with the help of the Hoarders team of experts, Andy will clean up the property or lose everything

Darlene is a dynamic, outspoken, eclectic woman from Vancouver, BC. She believes in New Age energy healing, the fifth dimension, and describes her packed home as a "mystical mess." Darlene has so much stuff that she's hoarded herself outside, leaving her to sleep under a tarp on her porch. With winter coming, Darlene's exposed porch bedroom is about to get a lot colder--so something's got to change. Along with the team of experts, Darlene is going to try to regain control of her life and create positive energy in her home.

Jim has been a collector from a very young age but some of the tragedies in his life have compounded Jim's hoarding behavior. In 2019, Jim's daughter, Elesha, lost her job and needed a place to stay so she moved. Moving in with Jim however, dealing with the hoard has been the most difficult part of her life. Code enforcement has already performed a severe forced cleanup on Jim's house in 2016 which only made matters worse. Now with the help of the Hoarders team of experts, either Jim will clean up the property or code enforcement will take another forced cleanup, and Jim could lose everything.

Roz grew up on the east coast of Canada with 13 siblings; nothing went to waste; when her first marriage fell apart and she took up with another hoarder, her house became unmanageable; with the help of the team, she intends to unclutter her life.

Marjorie has collected items from thrift stores and estate sales over the years for various project which has led to a massive amount of clutter in her home making living in the space very difficult.