A man dies a violent death aboard a boat at dawn. Although there is an eye-witness, he claims he was too far away to identify the killer, and the Homicide detectives have some fast thinking to do as they pursue their suspects around the confusing world of the waterfront.

When William Nelson blows up the car of a business acquaintance, killing him, he is quickly brought to justice, and sentenced to serve a life sentence for murder. However, Nelson is cunning and resourceful, and escapes from custody – and it is not only his freedom he wants, but a chance to even up the score against the main prosecution witness.

A convict who has broken out of jail is murdered at the rendezvous with an accomplice, and Det. Sgt. Bronson suspects that there is a connection between his death and an unsolved robbery committed five years earlier.

Retired Inspector Bob Fenton, former chief of the Homicide squad, is fatally stabbed and his body left in the driveway of the home of Insp. Connolly. Fenton appears to have been the victim of revenge, and Connolly realises that he could be the next target.

A business colleague of Douglas Hadrion, knowing he has a weak heart, succeeds after several attempts in causing his death by inducing a heart attack.

A body found floating in Port Phillip Bay is identified as that of gambler George Duff. He has been shot. Homicide detectives are surprised when their investigations reveal that Duff was married to the headmistress of a leading girl's school.

A water skier is murdered when she takes a tumble and the speed boat bears down on her. Police soon find a connection between a baby sitting agency, a group of juvenile delinquent motor cyclists and a series of burglaries.

Catherine Leonardson has a wealthy husband who has taken second place to the other men in her life. Tension in their home turns to murder, and detectives find evidence making two men look equally guilty.

An ingenious plot to steal a consignment of diamonds leads to murder, and detectives are baffled as to who the culprits are - until they turn their attention to a number of large crates recently delivered to a factory.

Two criminals kidnap a doctor in order to treat a wounded man who was injured during a gunfight in which another man was killed.

The Homicide squad has help from the Forensic division when investigating the death of a woman who had apparently ceased to exist a year before being killed.

Matters are complicated for the police when a young girl shirks from the publicity she fears will result if she makes known the full story of her abduction and gang rape, following the revenge which was meted out to her assailants.

A man found dead in a burnt out car at the foot of a cliff is presumed to be the owner, James Bannister. But further evidence points to Bannister still being alive, and detectives gradually unravel an insurance fraud which ends in another murder.

When Homicide detectives probe the underworld to investigate the murder of a prostitute, they find the dead girl's friends and accomplices all fear for their own lives. Their investigations are complicated by an obvious crank with a passion for reforming people.

When con-man Hal Dunstan gets over-confident, a chance encounter with a prowler in a graveyard triggers more than he can cope with.

A series of apparently unrelated crimes appear to be the work of a careless amateur, until a discovery by an old tramp and a fatal bashing set detectives on a new line of inquiry.

When prominent Melbourne solicitor Gerard Marquard is killed, detectives connect his death to the disappearance of a forged document. They concentrate on two suspects: one a well-known confidence trickster, the other a young German migrant.

The murder of a baccarat king leads to an arrest. The charged man has a watertight alibi, but wagging tongues and mistrust force the killer to strike again.

Sen. Det. Mackay joins Homicide, and is immediately implicated in a store robbery because he is being framed by another criminal. Det. Fraser is promoted and transferred to another squad.

A young mother is murdered and her small daughter is missing. Police and trackers comb rugged country for the killer, and question relatives about the little girl whose disappearance is obviously connected to her mother's death.

A girl en route to her city office finds a dead man lying on a rooftop. During the subsequent investigation, Homicide detectives uncover some shady dealings with her father's business.

A bookmaker is brutally robbed and murdered, and Homicide detectives suspect a group of punters led by smooth talking Johnny Parke. Their search brings them to further violence when tension flares up between the suspects.

A relationship develops between two migrants who have a love of music. She has an incurable illness and is going to die. Both decide to commit suicide. He kills her but he doesn't have the courage to kill himself.

When a body is washed up on St Kilda beach, Homicide detectives discover that the victim was involved in the smuggling of narcotics.

The prompt rescue by Sen. Det. Mackay of a man who is nearly killed by a train leads to an unexpected clue and a tragic reason behind the death of a woman.