Something weird seems to be happening to our weather - it appears to be getting more extreme. In the past few years we have shivered through two record-breaking cold winters and parts of the country have experienced intense droughts and torrential floods. It is a pattern that appears to be playing out across the globe. Hurricane chasers are recording bigger storms and in Texas, record-breaking rain has been followed by record-breaking drought. Horizon follows the scientists who are trying to understand what's been happening to our weather and investigates if these extremes are a taste of whats to come.

Over the past year, Horizon has been behind the scenes at one of Britain's leading cancer hospitals, the Royal Marsden in London. The film follows Rosemary, Phil and Ray as they undergo remarkable new treatments - from a billion pound genetically targeted drug designed to fight a type of skin cancer, to advanced robotic surgery. We witness the breakthroughs in surgery and in scientific research that are offering new hope and helping to defeat a disease that more than one in three of us will develop at some stage of our lives.

At the heart of the AIDS epidemic in Africa, there is a deadly mystery that has puzzled scientists for years. There are groups of people who are four times less likely to get HIV than other people, sometimes living just yards away, across a single valley - people with apparently similar behaviour and lifestyle. Scientists realised that if they could understand why these people are so much less vulnerable to the HIV virus, it might lead to an answer that could save millions of lives. And after 15 years of detective work it turns out there may be a remarkably simple answer: the high risk areas for HIV coincide with tribes who are uncircumcised. In Africa, it seems a man is much more likely to get HIV if he is uncircumcised. In Kaoma, Western Zambia, a young boy is on his way to the sacred Mukondaa - the tribal circumcision ground. Around him the tribal elders are gathered, dressed in their ceremonial garb, and vivid masks. But the young boy himself is an outsider, not from this tribe, and none of his relatives or ancestors have ever been circumcised. In fact, his parents are only prepared to break the taboo of their own tribe because they believe that circumcision could save his life by protecting him from AIDS. At first sight this belief seems like the kind of superstition to which desperate people often turn in times of plague. But now there is scientific evidence that suggests these people could well be right. There have now been twenty seven statistical studies that show a big difference in HIV infection between circumcised and uncircumcised men. For example, among the uncircumcised people of Kisumu in Western Kenya, a man is three times as likely to get AIDS than his circumcised neighbours. Among truck drivers in Mombasa the difference is four-fold. Horizon travels across Africa, tracing the work of scientists who have unearthed the statistical data behind this correlation. At the same time microbiologists have been battling to understand the complex and insidious virus, and their work indicates that the foreskin may be a key entry point for HIV. The logical conclusion for these scientists is that if you remove the foreskin, you begin to protect the man. No-one believes that circumcision can protect completely - the evidence so far only indicates that it reduces the risk of infection by HIV, and then only during heterosexual sex. Unquestionably, condoms are still the best protection. But in the many countries where the use of condoms is minimal, it seems that circumcision might help to reduce the spread of AIDS. In the absence of a vaccine for AIDS, and the lack of condom use in the developing world, should governments think the unthinkable and encourage the circumcision of young boys in non-circumcising tribes as a public policy? Opposing this idea are the voices of tribal elders who are loath to change tribal traditions that have existed for generations, and a fierce Western anti-circumcision lobby which believes that circumcision is a form of mutilation and violates basic human rights.

Horizon investigates how mankind is now polluting the world's oceans with extreme noise caused by many sources such explosions and super tankers.

Changes to the bacteria that live inside all of us are responsible for increasing the number of people with allergies, suggests new research. The show investigates this claim by conducting a unique experiment with two allergic families in order to find out just what it is in the modern world that is to blame. With a raft of mini cameras, GPS units and the very latest gene sequencing technology, the show discovers how the western lifestyle is impacting their bacteria. Why are these changes making people allergic? And what can be done to put a stop to the allergy epidemic?

In this episode, Horizon looks at connections between crime and poor housing design in the USA.

Particle physicist Professor Brian Cox asks, 'What time is it?' It's a simple question and it sounds like it has a simple answer. But do we really know what it is that we're asking? Brian visits the ancient Mayan pyramids in Mexico where the Maya built temples to time. He finds out that a day is never 24 hours and meets Earth's very own Director of Time. He journeys to the beginning of time, and goes beyond within the realms of string theory, and explores the very limit of time. He discovers that we not only travel through time at the speed of light, but the experience we feel as the passing of time could be an illusion.

Horizon examines the design of Formula One racing cars with a particular reference to the aerodynamic 'skirt'.

Horizon presents a documentary on the advances of computer graphics and its multiple uses in simulating reality in industry and science. It looks at the manipulation of 3-D images to paint, animate, design, and test scientific hypothesis.

Horizon puts Graham Hancock's controversial theories about the past to the test, dissecting his evidence for a lost civilisation. Graham Hancock offers various pieces of evidence to support his theory. He claims that the mysterious lost civilisation left its mark in ancient monuments, which he calculates were built to mirror certain constellations of stars. His hugely popular ideas have attracted such a wide audience that they stand to replace the conventional view of the past, which is based on scientific evidence that the civilisations of the ancient world were developed independently, by different peoples, on different continents.

This Horizon documentary examines the Infra-Red Astronomical Satellite (IRAS) which has detected evidence of planetary systems around distant stars.

A billion miles from home, running low on fuel, and almost out of time. After 13 years traversing the Saturn system, the spacecraft Cassini is plunging to a fiery death, becoming part of the very planet it has been exploring. As it embarks on its final assignment - a one-way trip into the heart of Saturn - Horizon celebrates the incredible achievements and discoveries of a mission that has changed the way we see the solar system. Strange new worlds with gigantic ice geysers, hidden underground oceans that could harbour life and a brand new moon coalescing in Saturn's magnificent rings. As the world says goodbye to the great explorer Cassini, Horizon will be there for with a ringside seat for its final moments.

Horizon examines the concept and implications of a global village in Third World countries.

Horizon investigates how food allergy has developed from the 1950's to the present.

In this episode, Horizon look at attempts to persuade major respected organizations to do controlled trials on a synthetic malaria vaccine.

Horizon follows five teams of scientists on the island of Mauna Kea in Hawaii as they wait for a solar eclipse.

When and how did space and time begin? The birth of the Universe is one of the biggest mysteries in astronomy. It has perplexed the best scientific minds for centuries. Decades before space travel was possible, astronomers dreamed of putting a telescope into orbit to try and answer these fundamental questions. It wasn't until the 1970s, when space flight had become a reality, that NASA resolved to build just such a space telescope. They named it Hubble. This was one of the most ambitious missions ever conceived. The technical challenges were enormous and it took 12 years to design and build. Travelling at seventeen thousand miles an hour, the Hubble Telescope would take pictures of the furthest reaches of space, transmitting them 400 miles back to Earth. In April 1990 the Hubble Space Telescope was launched. But just weeks later, disaster struck - the $2 billion telescope had a fatal flaw in its main mirror. This was not just a disaster for NASA; it was a national scandal. Hubble had to be saved; scientists and engineers began to search desperately for a solution to the problem. Plans for an adventurous repair mission began to take shape but it was two years before work could be carried out. It took astronauts five gruelling space-walks to carefully replace the instruments and patch up the telescope. But nobody knew if Hubble would be able to deliver on any of its original promises. Finally, the miracle happened. An unexpected avalanche of data from Hubble confirmed that the telescope was fixed. At last it began to solve the most fundamental puzzles of the Universe. Hubble has given us breathtaking images of the birth of stars; it has found black holes swallowing matter at the centre of galaxies; and last year the Hubble Telescope resolved the most fundamental question in astronomy - the age of the Universe. At last, half a century of scientific endeavour was rewarded. Horizon marks the 10th anniversary of the launch of the Hubble Space Telescope by tracing the extraordinary tale of triumph, disaster and eventual success of this unique window into the Universe.

The world's oceans claim on average one ship a week, often in mysterious circumstances. With little evidence to go on, investigators usually point at human error or poor maintenance but an alarming series of disappearances and near-sinkings, including world-class vessels with unblemished track records, has prompted the search for a more sinister cause and renewed belief in a maritime myth: the wall of water. Waves the height of an office block. Waves twice as large as any that ships are designed to ride over. These are not tsunamis or tidal waves, but huge breaking walls of water that come out of the blue. Suspicions these were fact not fiction were roused in 1978, by the cargo ship München. She was a state-of-the-art cargo ship. The December storms predicted when she set out to cross the Atlantic did not concern her German crew. The voyage was perfectly routine until at 3am on 12 December she sent out a garbled mayday message from the mid-Atlantic. Rescue attempts began immediately with over a hundred ships combing the ocean.

This is the story of two genuine scientific heroes. For forty years, John Bahcall and Ray Davis were engaged in a single extraordinary experiment - to find out why the Sun shines. In the end they would triumph. Davis would win the Nobel Prize and, thanks to their work, a whole new theory about how the universe is put together may have to be created. At the heart of this story is a tiny, utterly mysterious thing called a neutrino. Trillions of them pass through your body every second, touching nothing, leaving no trace. Yet neutrinos are one of a handful of fundamental particles in the universe, essential to every atom in existence and clues to what makes the Sun work. But their ghost-like quality made trapping and understanding them immensely difficult. What then followed was a bizarre series of experiments. They led from a vat containing 600 tons of cleaning fluid, to a vast cavern in a Japanese mountain, to a hole in the ground in Canada two kilometres deep. What they would reveal would stun the world of science. It seems that neutrinos may be our parents. They may be the reason why everything, including us, exists.

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Horizon explores the topical scientific issues investigates, the truth behind our fear of radioactivity and asks whether our nuclear nightmares really are based on reality. From Hiroshima to Chernobyl scientists have been studying the impact of exposure to radiation for over 60 years and have always assumed that any level of radiation is bad. But now some scientists are questioning the power of radiation to cause cancer and finding evidence to suggest that it may have beneficial health effects.

With the help of a hammer-wielding scientist, Jennifer Aniston and a general anaesthetic, Professor Marcus du Sautoy goes in search of answers to one of science's greatest mysteries: how do we know who we are? While the thoughts that make us feel as though we know ourselves are easy to experience, they are notoriously difficult to explain. So, in order to find out where they come from, Marcus subjects himself to a series of probing experiments. He learns at what age our self-awareness emerges and whether other species share this trait. Next, he has his mind scrambled by a cutting-edge experiment in anaesthesia. Having survived that ordeal, Marcus is given an out-of-body experience in a bid to locate his true self. And in Hollywood, he learns how celebrities are helping scientists understand the microscopic activities of our brain. Finally, he takes part in a mind-reading experiment that both helps explain and radically alters his understanding of who he is.

By our third year, most of us will have learned to count. Once we know how, it seems as if there would be nothing to stop us counting forever. But, while infinity might seem like an perfectly innocent idea, keep counting and you enter a paradoxical world where nothing is as it seems. Mathematicians have discovered there are infinitely many infinities, each one infinitely bigger than the last. And if the universe goes on forever, the consequences are even more bizarre. In an infinite universe, there are infinitely many copies of the Earth and infinitely many copies of you. Older than time, bigger than the universe and stranger than fiction. This is the story of infinity.

Conjoined twins are among the rarest of human beings. There are probably fewer than a dozen adult pairs living in the world today. Only a few hundred pairs of conjoined twins are born in the whole world each year - they appear about once in every 100,000 births - but more than half of them are stillborn, and one in three live for only a few days. Of those who survive, a very small number will be selected for separation surgery. But as there are few hospitals with the skills and experience to perform this kind of surgery, separation is still a very unusual event. The harrowing decisions which surgeons have to make when faced with conjoined twins have been highlighted by the recent case in Manchester, England. Separating conjoined twins is not only technically challenging; it can involves life and death decisions about whether one twin should be sacrificed in the hope of saving the other. But "sacrifice surgery" has a poor record of success, and the Manchester case is the latest round in an international debate about the value of separation operations. The confidence of the surgeons, who believe that separation is essential, is challenged by medical historian, Dr Alice Dreger of Michigan State University. She argues that twins themselves might take a different view - if they were ever given a chance to express it. Horizon interviews two pairs of adult conjoined twins - Lori and Reba Schappell in Pennsylvania and Masha and Dasha Krivoshlyapova in Moscow. Lori and Reba are joined at the head; Masha and Dasha are joined in their lower body. They say that they prefer their conjoined lives, despite the problems and challenges, rather than face the risks of separation surgery. Lori and Reba live independent lives in their own apartment in Pennsylvania; Lori enjoys working with computers and Reba is developing a career as a country singer. Masha and Dasha had a difficult childhood; they were subjected to medical experimentation when they were very young and hidden away from the public. Since the end of the communist era they have been able to tell their story. Their autobiography is being written by a British journalist, Juliet Butler. Horizon also follows surgeons at the Red Cross Children's Hospital in Cape Town, Africa as they plan to separate eight month old twins, Stella and Esther Alphonce. The baby girls are joined at the hip, and the surgeons have little doubt that they can and should be separated, even though the operation carries risks of disability for the twins. Historically conjoined twins who were not, or could not be separated have lived successful lives, even if this involved putting themselves on public display. The original Siamese twins, Chang and Eng Bunker, were joined by a narrow strip of flesh and could easily be separated today. Like Millie and Christine McCoy, who also lived in the USA in the middle of the last century, they earned fame and fortune touring the world. But life for conjoined twins has never been easy, Millie and Christine were kidnapped and sold several times in their childhood. The British conjoined twin sisters, Violet and Daisy Hilton, provoked a scandal in the USA when one of them tried to get married. They did eventually marry, but they were never separated. The tragedy for conjoined twins who spend their lives together is that they inevitably die together too. When one twin dies, the heart of the other twin keeps pumping until he or she is drained of blood. Is this another reason why twins should be separated when they are young? There are no simple answers, because every pair of twins is unique.

A trail from Greenland to Britain via Latvia offers new evidence into how evolution could have seen aquatic life form legs and walk.