At a school for at-risk youth in Illinois, Sarah Kolb rules the hallways. She takes new student Adrianne Reynolds under her wing, showing her the ropes and introducing her to the popular crowd. As the two get closer and closer, people around them start to wonder if they're more than best friends. But in this school, only one of them can be the most popular. Jealousy leads to contempt, and rumors spread like wildfire... until a final showdown after class turns into a deadly confrontation.

When LA native Stephen Eldridge needs a new place to live, he turns to his best friend, Miki McDermott. Stephen and Miki have a lot in common. Both are gay, single, and outgoing, and both come from big, loving families. Stephen runs his own landscaping business, and Miki is a respected nurse. But what starts out as a simple living arrangement soon gets complicated. After they sign an insurance policy on the mortgage, one of them decides that in this house, two is a crowd.

At the world's top university for the Deaf and hard of hearing, college freshmen Eric Plunkett and Joseph Mesa live across the hall from each other. Eric is an outgoing film buff with a preference for horror movies... Joseph, a talented athlete from the island paradise of Guam. But for one young man, the pressures of college will be too much. The secret he's been hiding will drive him to kill... and no one will hear his victims' screams.

When retired rodeo champion Bob Huber takes a young, aspiring cowboy named Ryan Bryant under his wing, it seems like a perfect match. The two start running a business and coaching a little league team. Yet slowly but surely, one man begins to chafe under the yoke of their friendship and hatches a plan to rid himself of the other ... forever. In a ruthless competition between the wily older man and the strong young buck, who will win?

Gerry Scotti and Barry Feldman are living the good life in Los Angeles. Gerry is a high-powered defense attorney, Barry his brilliant paralegal. They become best friends, each complementing the other's strengths and weaknesses. But there's a dark side to their work, defending drug dealers and other accused criminals. And Barry has a problem, a gambling addiction that already landed him in jail. As the stakes get higher, one of them will do anything to avoid losing it all.

Can guys and girls ever really be best friends? It's a question Alphonze Fitzhugh and Britani Coberly hear many times--and they always shrug it off. These Northern California teenagers are more like brother and sister, sharing a passion for sports and meeting up with their friends for bonfires in the local vineyards. But like a grape that isn't picked, this friendship withers on the vine. Hidden attraction turns into jealousy, which then sets off a chain reaction of anger and revenge.

A chance encounter during a coming-of-age summer brings teenagers Michelle Jensen and Jason Means together. Meeting on a camping trip, they seem to come from different worlds. Michelle has a stable, church-going family, while Jason has a more troubled background. But both are hoping to walk in the other's shoes. It's a summer of first love, exploration, and heartbreak--only to end in a terrible, senseless murder on a dark Iowa road.

Any time best friends turn on each other, it's a tragedy--years of love and trust swept away in a moment of anger, jealousy, or greed. But some cases are so shocking that nobody sees them coming. These are the seven least likely suspects from Season One of I Killed My BFF. Narrated in the voice of murder victim Misti Mayo, this special episode traces the stories of seven killers who fooled everyone... until it was too late.