President John F. Kennedy and his wife, Jackie, traveled to Texas with an eye on the 1964 elections, along with a team of secret service agents. During a motorcade in downtown Dallas, JFK is brutally shot in broad daylight and later tragically pronounced dead at Parkland Hospital with his grieving wife in the next room. America changes forever.

The race is on to track down JFK's killer, but before he is arrested, the assassin kills again. Meanwhile, Jackie Kennedy boards Air Force One to return JFK's body to Washington. Still wearing her bloodstained dress, she witnesses LBJ sworn in as president. As the net closes around suspected killer Lee Harvey Oswald, his co-workers and family face interrogation.

President Kennedy's body arrives back in Washington, and a grieving Jackie Kennedy leads the funeral march to honor him. In Dallas, Lee Harvey Oswald is charged with JFK's murder, but the world is shocked again when Oswald himself is shot dead while still in police custody by nightclub owner Jack Ruby. With Oswald dead, there is no reckoning, and America will never be the same.