Kathy addresses her breakup with husband Matt, goes on a “Red State” stand-up tour and auctions off a weekend stay for one at her house for charity. She also finds time to appear on “Jimmy Kimmel Live” and “The Tyra Banks Show.”

With fellow comic Michael McDonald and actress Karri Turner in tow, Kathy departs for Iraq to perform for the troops. While Michael ends up wowing the audience of soldiers, Kathy does not, at least at first. Also, Kathy discovers that military-issue food might be good for her figure.

Kathy's last days performing for the troops in Iraq turn perilously dramatic when two rockets are fired at the base. Back at home, Kathy cares for her niece and nephew, who get to meet “Laguna Beach” star Talan Torriero. Meanwhile, a “dog whisperer” tries to tame Pom-Pom, and a cranky Kathy copes with her diet.

Kathy tries to tame her badly-behaved puppy Pom-Pom before they both take to the catwalk in a dog-and-owner fashion show for charity called Paws for Style. Meanwhile, she also redesigns a suite in a sleek San Francisco hotel, teaches a class for aspiring comedians and works a private corporate event.

In the second season finale, Kathy and her assistant, Jessica, journey to Las Vegas, where Kathy gets up bright and early to host a buffet event. Later, she chills out by getting ice-skating tips from Olympian Johnny Weir. Also, Kathy appears on the TV show “Queer Eye for the Straight Guy.”

Life is busier than ever for Kathy since last season, and she's hired two more assistants, Tom and Tiffany, to help her keep up with the pace. Some of her upcoming events include a visit to the ladies of The View (which goes much better than last time thanks to Star's departure), a gig hosting a corporate film for Redken sales reps, and most importantly--a sold out show at Carnegie Hall! But not all of Kathy's recent changes have been pleasant...she and Matt Moline are now officially divorced, and she's not sure she's ready to face the world alone.

Now that she is single again, Kathy plans on jumping back into the dating pool and making a big splash by dating someone who will get her all the publicity that she needs. First in the mix is Nick Carter, whom she ends up going out with, but whose publicist tries to maintain the encounter out of the press.

Kathy is ready to set out on Rosie O'Donnell's lesbian cruise, but soon realizes that she must adjust her comedic material to captivate the lesbian audience. To do so, she enlists assistance from "Work Out" star Jackie Warner. However, and to her dismay, Kathy's comedy is not her only impediment, as she receives horrible news that may shake the entire course of her life from this point forward.

Following her tragic family loss, Kathy begins to ponder her legacy and wishes to resolve all her relationship issues. In the meantime, she is also offered a gig on a home-shopping network, hosts a performance in her hometown Chicago, and reconnects with an old high-school love.

Kathy gears up to host a gay adult-video awards gala. She also prepares to perform her comedy act in front of prisoners at a state penitentiary in Arizona.

Kathy and her posse journey to jolly old England for some D-list (mis)adventure and to promote the UK run of “Kathy Griffin: My Life on the D-List.”

In the third-season finale, Kathy scores an award from Irish America magazine. The recognition inspires Kathy to connect with her Irish roots, so she journeys with her posse to Dublin, where she offers a sweet gesture in memory of her father.

Kathy starts to think she has a chance of moving off of the D List after a string of awards and nominations. She heads down to Grammy HQ in order to beg/bribe/plead them into giving her and award! Kathy meets up with Bette Midler who offers her a part she cannot refuse.

Kathy's determination to get a Grammy nomination has paid off, but she won't rest until she has won the award. Kathy starts calling round previous winners in an effort to secure their votes. She ends up heading to Canada where she speaks to Lily Tomlin.

The Grammy's are finally here and it's time to see if all Kathy's hard work has paid off. When things don't go as planned, Kathy heads to Georgia in order to put her disappointment behind her.

Kathy realizes that to appeal to the younger generation, she needs to brush shoulders with young Hollywood stars. She lands a spot on a teen drama and spends the day with Paris Hilton, while she allows her mom to set up her Facebook page for her.

Kathy decides to write a tell-all book; Kathy grants Maggie a series of wishes.

Kathy is looking for a second home and Star Island seems to be the perfect location. Kathy meets up with some fellow celebrities and also works in a hotel.

Kathy tries to bring in a new audience by appearing at the Apollo Theatre, and she meets Katt Williams.

Kathy joins in the protest for gay rights as she travels to Sacramento. She meets up with Melissa Etheridge who has a new nickname for her.

Kathy's gets her hopes up about getting out of her D list status once she hears a lifelike model of her is in the works. She also works on her book by meeting famous famous authors and going to a photo shoot for the cover.

Kathy visits Suzanne Somers' home and gets a star on the Palm Springs Walk of Stars.

Kathy gets some help from Liza Minnelli in order to gain confidence for her guest spot on Law & Order: SVU.

Kathy takes part in judging a toddler pageant where she adds her own artistic touch, and she also has her home remodeled.

Kathy heads north for a very busy trip to Alaska. She meets up with her friend Levi Johnston to do a book signing, performs stand up, and turns host for a dog-sled event.