Giacomo's provisional release re-starts the investigation into the crime at the golf club. Meanwhile, Alice discovers that someone is looking for information on Manes: perhaps the person she so desires to meet is closer to her than she imagines. For Alice and Claudio the day set for the wedding has arrived, but it passes in vain.

Claudio and Alice follow an intuition that can exonerate Giacomo. Paolone is also summoned for his first report: the mysterious death by poisoning of a well-known food critic. Alice's stubbornness, meanwhile, leads her to make one last attempt in the quest that the Supreme had given up.

Alice is intrigued by the arrival of Giacomo, Claudio's brother with a wild and unconventional charm. He would like to know what has divided them in the past, but Claudio does not confide, even now that they are getting married. In any case, Alice's attention, rather than Claudio's reluctance, is focused on the Suprema: she appreciates its rigor and considers it a model of life totally different from what she had always imagined for herself. During the investigation into the murder of a sushi chef, Silvia confronts Alice about her working relationship with PM Einardi. At the institute Erika asks Paolone to help her conquer the fascinating Sandro who instead seems to have a keen interest in Alice. The first meeting between Giacomo and the Supreme generates sparks, leading Claudio to be even more irritated by the presence of his brother.

Alice and Claudio are at loggerheads for Giacomo's presence and for the numerous tasks entrusted to the student by the Supreme. By order of Manes, they are summoned to shed light on the death of an Olympic rifle champion killed in a firing range. Forced closeness doesn't make things better, while the Supreme senses that Alice has discovered her secret.

Alice is destroyed by suspicions of Claudio's betrayal and returns the engagement ring, sending him into a rage. To cheer her up, Wally involves her in her secret project and Silvia suggests reprisals. Meanwhile, a famous trapper is killed just before a concert and the difficult expertise is entrusted to the Suprema herself, who decides to take Alice with her. Sandro sees an opportunity and decides to come forward with Alice, but does not realize that Claudio has seen it all ...

Alice and Claudio begin preparations for the wedding, but she notices that he is hiding something from her. While Alice is working on the murder case of an old prof. in psychiatry, the historic friendship with Lara and Paolone is put to the test by the doctoral announcement: there are only two places up for grabs, the loser will have to leave the institute.

The investigation into the tragic accident that occurred to a stunt double during the shooting of a film captures Alice's attention, making her forget an appointment with Claudio. The relationship of love between the two becomes more and more turbulent, while Sandro, who supports her in the inspection, is increasingly fascinated by her. Marco has an important job opportunity that puts him and Lara at a crossroads. While working on the research that Manes has entrusted to her, Alice's unstoppable curiosity leads her to discover an unspeakable truth about the Supreme.

Mutual jealousy causes sparks between Alice and Claudio, but Giacomo's sudden arrest calls everything into question. Claudio's brother is accused of the murder of an industrialist in a golf club. The motive is there and Silvia's investigations reveal unsuspected truths about Giacomo and Claudio's past to Alice and the Supreme. Alice and Claudio find themselves united in believing in Giacomo's innocence, even if all the evidence seems to confirm his guilt.

Claudio does his utmost to protect Alice, but at the same time keeps her at a distance, while trying to prove Giacomo's innocence. Meanwhile, Lara asks Alice to collaborate on her first appraisal: a boy died while doing parkour and it is necessary to carry out the relevant findings. Just when Erika realizes that her feelings for Paolone go far beyond friendship, he moves away.

"Sacrofano, what do you say if we get married?" This is how, in the midst of an autopsy, Claudio makes his marriage proposal to Alice. Meanwhile, a new director, Andrea Manes, and two first-year postgraduates, Giulia and Sandro, have arrived at the Institute of Forensic Medicine, while Professor Boschi, aka "Wally", is exiled to the basement.

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The death of an elderly playboy during the funeral of a friend of grandmother Amalia's and the unexpected involvement of her grandmother in the investigation push Alice and Lara to entrust Camilla to the most unlikely babysitter: Cordelia. Meanwhile, someone has enrolled Paolone in a cooking talent, but the outcome will not be quite what they hoped for. Alice has a formidable intuition that could prove Giacomo's innocence and to verify it goes beyond the limits of what is allowed.

Alice is a young graduate in medicine who does not yet know what specialization to take, nor what to really do in her life. The death of her grandmother's caregiver, which occurred under unclear circumstances, will make her choose forensic medicine.

Alice did it: now she is a specialist in Forensic Medicine! He understood that life inside the Institute will be anything but easy, but soon something new knocks on his door. His name is Arthur.

A new case involves our coroners: a boy in custody dies of respiratory failure following a fatal stroke. Meanwhile, love and work do not run in the same direction.

Could it be true that in love who flees wins? Arthur is gone and Alice, who hasn't heard from him for days, is in a panic. Meanwhile, a diver dies during a competition: according to Claudio it is an obvious case of doping.

Alice, on the eve of the first dinner at the Malcomess home, feels more insecure than ever. Meanwhile, the owner of a beauty clinic dies before undergoing plastic surgery.

An African woman is found dead on a provincial road. Scarred with acid, she is supposed to be a prostitute. However, the detail of a tribal scar allows Alice to trace her identity.

Things with Arthur are not going well: Alice feels him distant and they often quarrel. Meanwhile, the case of a woman found dead while jogging distracts her from her study.

Alice can't talk to Arthur: above all she doesn't know how to tell him that she and Claudio will leave alone for his first medical congress. Meanwhile, the mysterious disappearance of a woman calls Alice into Claudio's case.

Alice would like to tell Arthur the truth about the night she spent with Claudio but she doesn't have time because Arthur has to leave immediately. Meanwhile, a cold case linked to the discovery of some bones recalls the two coroners.

Alice is suspended between the need to tell the truth to Arthur and to indulge the feeling for Claudio. Meanwhile, the case of a famous writer's interdiction draws the attention of medical examiners.

A transsexual is found dead in the courtyard of an apartment building. A single shoe testifies to his last leap into the void. What prompted him to die?

Summer is over and it's time for Alice to go back to the Institute. Among the tasks that Wally immediately entrusts her is that of tutoring Erika, a new resident. In the meantime, human bones are found in the basement of an archaeological area. Alice and Claudio, with whom the girl continues to live a turbulent love relationship, go to the place. Here Alice meets the fascinating PM Sergio Einardi and soon discovers that, between the man and Conforti, there is a mysterious resentment linked to the past.

Claudio and Alice continue to have opposite points of view on love. Meanwhile Ambra mysteriously disappears and Claudio seems to be very worried. A pharmacy robbery degenerated into murder leads Alice and Conforti to meet Einardi again, who once again does not hide a keen interest in the student. In the meantime, the Supreme Prof. Malcomess, director of the Institute, communicates the decision to retire, opening the race to his succession and calling for a competition among the trainees for a scholarship in Baltimore.