It's Christmas time and the Murtaugh family is headed to Hawaii. Murtaugh's vacation is put on hold when he and Riggs are called to a homicide and the victim is an old friend. Riggs gets a surprise phone call from a relative just in time for Christmas.

Murtaugh follows Riggs down to Mexico, where he plans to avenge his wife's death and finish off Tito Flores once and for all. Once back in the States, they have a few people to answer to during the ongoing investigation around Flores, including Murtaugh's family. Avery is questioned by Internal Affairs about the integrity of his department.

The squad is on high alert after an apparent threat is made on Riggs' life. With Murtaugh taking on more responsibility at work, he and Riggs have to deal with their changing relationship. Trish gets caught up in some trouble. Molly asks Riggs to make a big decision about their future.

Murtaugh and Riggs suspect misuse of power in the LA Sheriff's department when they investigate the killing of a Texas Ranger.

Murtaugh and Riggs search for the culprit of a local jewelry heist. Murtaugh gets called 'grandpa' by another parent while at the playground with Harper, sending him into a tizzy. Riggs deals with withdrawal from drinking.

A brutal car crash reveals that Cahill is the target of a murderous stalker, causing Riggs and Murtaugh to turn the tables and start asking her questions for a change. After finding Murtaugh's file in Cahill's office, Riggs becomes obsessed with finding out about his. Roger and Trish reel over their daughter's newfound fake ID.

A doctor is found dead in the pool of a wellness clinic. Riggs suspects a drug angle and asks Agent Palmer for help.

Riggs is reunited with childhood friends and comes to realize they might be mixed up in the robbery-homicide case he and Murtaugh are investigating. Murtaugh finds a joint stashed in his kitchen that he brings to Scorsese for testing in effort to bust one of his kids.

Riggs and Murtaugh are drawn into a fatal world of conspiracy theories. Riggs' relationship with Molly evolves. Murtaugh and Trish attempt to get Harper into a fancy pre-school.

After a mansion break-in turns into a homicide, Murtaugh and Riggs set out to find the culprit. Murtaugh and Trish question their trust in Riana as she gets into some trouble with new friends. Riggs recalls his troubling childhood and finds a true family with Molly and Ben.

Murtaugh and Riggs respond to a robbery that takes place 20,000 feet in the air. The investigation turns into an ongoing hunt for an unreliable father, with his daughter being their main witness. Murtaugh faces hostility from his daughter as he tries to connect with her.

Riggs and Murtaugh are led into the underground mob world as they investigate a murder in a hospital. Murtaugh learns that Riana is secretly dating his neighbor and nemesis' son. Riggs spends more time with his childhood friend. Scorsese's real name is revealed.

Murtaugh and Riggs respond to the murder of an escaped patient of Dr. Cahill's who mysteriously goes off the rails. Riggs' anger gets the better of him once again, causing Avery to consider whether or not he is fit to serve. Family tension runs high between Murtaugh and Trish, who have to make big decisions about R.J.

After the fatal end to an argument on a construction site, the squad works to untangle facts about the incident. Riggs struggles to rekindle his relationship with Molly. Trish's job is on the line as she tries to close a big deal at work. Murtaugh gets one last chance to make it right at home.

On Murtaugh's first day on the job as interim captain, the wife of a popular businessman is abducted and the squad finds a connection in the case to Rigg's father. Riggs is left to grapple with his family and work.

When Cole is investigated by the FBI, Murtaugh is forced to question his loyalty to his own partner. Meanwhile, Cole works a case that puts Natalie's fiancé, Andrew, into the crosshairs right before their wedding day.

Riggs and Murtaugh team up again with Palmer, and together they gain inside knowledge of dangerous new cartel operations. As Riggs’ attachment to Palmer deepens, so do his impulsive actions, further worrying Avery and Delgado. Trish explores the potential of an amazing new career opportunity.

Murtaugh and Riggs investigate the mysterious death of famous singer Shaye's bodyguard. Murtaugh turns to his daughter—a fan of the singer—to learn more about Shaye's background and uncover the possible suspects. Riggs learns the responsibilities that come with being in a relationship with help from Murtaugh.

Murtaugh and Riggs investigate a death that occurs moments before the victim's bet wins a horse race. Leo Getz insists it's a homicide and aids in the investigation. Murtaugh updates his will. Riggs struggles to come to terms with his past.

Riggs and Murtaugh are thrown into the world of counterfeit money. When a group of teenagers inadvertently gets involved, it strikes a chord with Murtaugh, who is dealing with his own issues regarding his son. Riggs decides to pay a visit to someone from his past.

Riggs takes a trip down memory lane while visiting his father-in-law in prison, which reminds him about an old secret regarding his deceased wife.

Bailey's sister runs into trouble with the law, and she must decide how far she'll go to protect her family. Murtaugh must help Riana navigate boy problems. Riggs deals with the fallout of a night of heavy drinking.

After the city's gun buy-back program is robbed, the team is on a hunt for those responsible. Murtaugh walks on thin ice with Trish. Riggs finds an unlikely friend in Ruthie. Avery is reunited with a college 'frenemy' who has key information about the case.

The duo sets out to unlock a case about a veteran hitman who Murtaugh has followed for years. Riggs struggles to find a connection with his father. Murtaugh scares Riana with his overprotective driving lessons. The team members finds themselves wedged in a dangerous incident that tests their trust.

The whole precinct’s holiday celebrations are cut short when they’re called to examine a ruthless homicide.