Former international CIA operative, Wesley Cole returns home and assumes duty as a police officer with the LAPD. Cole will find himself navigating a new partnership with Murtaugh, as he adjusts to life in Los Angeles. Avery continues his campaign for city council.

Cole reflects upon his time working for the CIA, as a person from the past makes a startling reappearance. Murtaugh struggles with his own mistakes, after a murder raises questions about a suspect he put away years prior. Leo Getz returns as the attorney on the case and tries to convince Trish to join his team.

New partners Murtaugh and Cole attempt to find a steady rhythm as they work to solve the murder of a finance executive. Cole navigates his role with his ex- and his daughter. Avery grapples with the outcome of his campaign for city council.

When Cole and Murtaugh investigate a case involving a father and daughter crossing the Mexican border, they end up uncovering a major issue with California Boarder Patrol. Meanwhile, Trish prepares her campaign for D.A. and must face parts of her past, before they find their way into the media spotlight. Cole also confronts his past when he experiences flashbacks as a result of an injury.

Cole juggles the realities of his job and his duty to be a good parent, as he and Murtaugh work together to bust a gang running a lottery scam. Murtaugh gets ready to celebrate his 30th anniversary with the LAPD and receives a surprise visit from his competitive father-in-law.

While Cole gets into the holiday spirit for his first Christmas with Maya, Murtaugh hopes he can convince RJ to come back home from Costa Rica for the holidays. Cole and Murtaugh are saddled with a complicated burglary and home invasion case. Avery's holidays are a bit blue. Bailey is still trying to figure out her new partner.

Murtaugh and Cole investigate a robbery of a truck filled with fine art. Cole deals with lingering feelings for Natalie following a new development in her life. Riana blackmails Murtaugh into letting her go to a concert after she catches him in a lie that he told Trish.

Against Murtaugh's advice, Cole reaches out to Tom Barnes to help with a case that hits close to home, putting Murtaugh and Cole's partnership to the test. Meanwhile, Trish prepares to announce her campaign for District Attorney.

Cole confronts his past when his former mentor delivers alarming news, as he and Murtaugh investigate a robbery of safe deposit boxes. Murtaugh clashes with Trish's new client and enlists Bailey's help to investigate her.

Murtaugh turns to Cole's former mentor for help on a high-stakes cartel case. Murtaugh and Trish meet Natalie and Maya for the first time. Tensions mount between Bailey and 'The Gute' as the new partners begin to work together.

Cole wants to talk to Natalie about their relationship before it's too late, but a wrench is thrown in his plans after he bumps into a new ADA, Erica. After being kicked out of the house for Trish's girl's night, Murtaugh finds himself an unlikely friend.

Murtaugh and Cole investigate the murder of an underground MMA fighter when Murtaugh realizes his fighting moves aren't as sharp as they once were. Meanwhile, Trish is unfulfilled by her practice and considers running for a public office. Also, Cole and Erica try to keep things casual and uncomplicated but their plan backfires when Maya reacts to her family changes in a negative way.

Cole finds himself on the rebound after Natalie's engagement, and his new romantic interest, Julie, has an unexpected connection to A.D.A. Erica, complicating things at work. Meanwhile, Murtaugh worries about the connection between the murder he's investigating and a new opportunity for Trish to serve as co-counsel on a high-profile lawsuit with Leo Getz.

A murder involving a high school football phenomenon draws Riggs and Murtaugh into the lucrative—and corrupt—world of college recruiting. Murtaugh considers a big change in his professional life. Riggs contemplates an even bigger shift in his personal life as he spends more time with Karen Palmer.

Murtaugh takes a family vacation, but is pulled back into work when he witnesses an alleged abduction. Cole is left to investigate a murder himself, but the two cases begin to intersect. Meanwhile, Erica's mother, Senator Malick, comes to town and stirs things up between Erica, Cole and the case at hand.

Riggs and Murtaugh's investigation of a drug cartel reunites Murtaugh with his former T.O. Riggs avoids the reality of Miranda's death by diverting himself with outside vices. Murtaugh and Trish struggle to find alone time.

The investigation of a young model's murder leads Riggs and Murtaugh to one of L.A.'s wealthiest families and Riggs is jolted when an old friend of his wife's is also linked to the case. Murtaugh is shocked to discover that his daughter is sending racy photos to her new boyfriend.

When Riggs and Murtaugh attend Leo Getz's surprise wedding, they end up investigating a missing person. Riggs comes face to face with someone from his past. Murtaugh receives news that might change his life forever.

A string of burglaries hits close to home for Murtaugh when one occurs in his own neighborhood, and it gets just as personal for Riggs when another break-in ends in a casualty. Roger Junior connects with an old friend who might be twisted up in some criminal action of his own.

After investigating the murder of a millennial 'designer drug' dealer, Riggs and Murtaugh find themselves in a violent turf war between a new generation of drug dealers and a Koreatown gang. Murtaugh finds some comfort in a temporary new partner. Trish attempts to set up Riggs with her co-worker.

Riggs and Murtaugh investigate the death of a surfer. Murtaugh grows suspicious of Trish's new friend, with whom she's been working on a charity event—and then learns it's NBA champion Scottie Pippen. Riggs has violent nightmares that bring up scars from his childhood.

A slightly unhinged former Navy SEAL lands a job as a police officer in Los Angeles where he's partnered with a veteran detective trying to keep maintain a low stress level in his life.

A noise complaint at a boxer's home leads Riggs and Murtaugh to a case involving illegal gun runners and Riggs becomes personally invested in the outcome when one of their targets reminds him of his late wife. Trish worries about Murtaugh's health.

Riggs and Murtaugh look into the murder of one of L.A.'s fashion expeditors and discover an underground DEA operation. With Trish and the kids away, Murtaugh goes on a 'bender'. Riggs has all-too-real dreams of Miranda.

When a car containing massive amounts of cocaine is stolen from an impound lot, Riggs and Murtaugh become embroiled in a notorious car theft ring. Murtaugh experiences some frightening chest pains. If Riggs' driving isn't enough of a trigger, the lead defense attorney on the case is none other than the terrifyingly brilliant Trish Murtaugh.