As Lizzie and her friends get ready for graduation, Gordo tries to figure out the perfect thing to write in her yearbook.

Lizzie meets Ronnie, a paper boy. She falls for him, and gets a series of firsts. First love, kiss, and heartbreak.

Lizzie starts a column on her school's website, but soon finds it difficult to handle when her good intentions backfire.

Lizzie is invited to play touch football with the guys, but she is worried when Ethan calls her a "dude," and she feels that she is losing her femininity by playing football.

Lizzie and Gordo worry about Miranda's diet; Matt expresses interest in the fine arts.

Lizzie's friends and family play a murder mystery party game at her house.

Gordo and Miranda visit Lizzie after she was out sick and bring her some scary news--in social studies class she has to pair up on a project with---KATE!! Lizzie reacts hysterically. She tries to get out of going to class the next day but her parents make her go. Kate is mad about working with Lizzie also, but she comes by the McGuire house to work on their project, cooking a Latvian dish called an Alexander Tort (a raspberry pastry ). At first the two are hostile to each other, but eventually they have a laugh or two and begin to recall the days when they were friends. Jo McGuire sees them enjoying themselves and tells the girls it seems like old times. Suddenly the girls stop being so friendly, then Kate excuses herself and leaves. At school Miranda and Gordo ask Lizzie how it went with Kate, expecting the worst. Lizzie says it wasn't so bad. In fact, the two are going to the Digital Bean to do work on a high-speed computer. When they get there, Kate and Lizzie are working fine, but

Lizzie and Matt switch bodies for a day, a la Freaky Friday. Matt (in Lizzie's body) and Lizzie (in Matt's body) go to each other's school and end up in amusing situations.

Lizzie tries to get all eleven of her pictures in the school yearbook, but Kate has other plans.

Parker, a girl that Gordo likes, turns down his offer to go with him to the school dance because of his height.

Lizzie and Miranda are ecstatic about being invited to a pool party given by their heartthrob, Danny Kessler. Mrs. McGuire is excited for Lizzie too until she finds out it's on the same day as grandma's 80th birthday party. She tells Lizzie she has to go to her grandma's instead and Lizzie is furious. The next day at school Miranda temporarily gets on the good side of Kate, the girls' former best friend who has literally and figuratively outgrown them. Kate invites Miranda to hang out with her crowd, causing a conflict between Miranda and Lizzie. At home Lizzie catches her mom on the phone making up a lie to get out of a commitment and accuses her of being a hypocrite. Gordo helps Lizzie to smooth over her differences with Miranda. Mom tells Lizzie she can go to the party after all, but she decides not to and spends the day with Gordo.

Lizzie falls in with a bad crowd when she befriends "bad girl," Angel, at school.

Gordo, always the nonconformist, has a new passion: 1950s & '60s Las Vegas lounge culture, as epitomized by Frank Sinatra and the ""Rat Pack."" Lizzie and Miranda don't care for it, but they buy Gordo a Rat Pack CD. Ethan Craft listens to it on the bus and, surprisingly, likes it, which makes the girls reconsider their opinion. Soon they are dressing in fashions of the time. Gordo thinks it's cool that they like it, but hopes that his new interest won't become the latest passing fad at school. But that looks like exactly what is happening as Ethan soon has all the guys wearing hats like Sinatra and listening to the music. Even Kate is admiring the girls for being in first on the new trend and actually asks for their advice on what to do!

Lizzie auditions to be in a fashion show presented by "Teen Attitude" magazine at a local mall and she gets accepted. At the show Lizzie looks great on the stage. Afterward, popular girl Jessica asks Lizzie to come to a party at her country club. Lizzie gets Miranda and Gordo invited also. At the party, all three are enjoying the fun, including the hot tub. But already Lizzie's friends are acting different. When Jessica asks her about coming to another party, Miranda starts answering for Lizzie like a press agent and she and Gordo start negotiating future appearances for her like a supermodel! At school things are very different, also. Kids stare at her in the hall like she's a celebrity. Kate is now fawning all over Lizzie, wanting to be her friend. Ethan is so starstruck that he can't even mumble a coherent sentence around her. Gordo and Miranda are as bad as anybody. Lizzie muses, "Gordo and Miranda aren't my friends anymore. They're my people!"

Lizzie begins mentoring a seventh-grader girl named Andie, who begins to mimic her characteristics and behave like Lizzie.

Gordo skips a grade and gets promoted to high school. After initial euphoria, Lizzie and Miranda start to miss Gordo.

When a babysitter cancels on the McGuires, Lizzie suggests that she's old enough to do the job for her brother Matt, but mom and dad say no. After much persuasion from Lizzie they relent, and Miranda and Gordo also come over to help. After Mr. and Mrs. McGuire leave, Matt generally causes havoc, spilling grape juice on the rug, acting bratty and taking advantage of Lizzie, who badly wants to impress her parents with her responsibility. Miranda and Gordo aren't much help as they won't follow Lizzie's orders either. At the restaurant Sam McGuire wants to sneak home and check on his daughter and son; Jo doesn't like the idea, but says just don't let them see you. Meanwhile at the house, Matt has knocked out the power. Mr. McGuire tries to peer in the window and goes tumbling over. The kids think he's a burglar and call the police. Mr. McGuire tries to get in the locked house and the kids wage a battle against him reminiscent of the movie Home Alone. The police come to arrest Sam. After al

Matt is irritating Lizzie with his magic tricks while she's trying to do homework. Soon they are fighting like cats and dogs--or brother and sister--much to the annoyance of their parents. But as soon as Sam and Jo stop them, they go right back to fighting. At school Ethan Craft speaks to Lizzie and Miranda, but Lizzie is so tongue-tied she can barely utter a word. Mr. Escobar announces a charity drive and asks for volunteers. Lizzie thinks she'll be too busy until she hears that Ethan will be there. At home Lizzie is making some cookies for the event when Matt tries out another trick. This time he handcuffs himself to his sister, but he can't get the cuffs loose. Mom spies the key and hides it, thinking that if the kids are forced to spend a few hours chained together, they might learn to get along better. Now Lizzie is facing the horror of going to the charity drive with her little brother stuck on her arm!

Lizzie's fantasy almost comes true when she is paired up with Ethan Craft in a CPR class at school, but he's so dense that the teacher chooses Tudgeman instead to give Lizzie mouth-to-mouth! Lizzie, Gordo and Miranda realize they are about the only three in school who haven't seen the latest blockbuster movie Vesuvius: The Eruption, which is rated R, and they're determined to get in to see it. When their parents all say ""no"" to their arguments, Gordo decides they should say they are going to play miniature golf, then go see the film. Lizzie is very nervous about lying to her parents, but she pulls it off with ease. The trio can't get past the ticket-taker, though, and can't slip in the back, so they mingle with the crowd as it is departing a showing and sneak in that way. While at the concession stand, they notice a man choking.

The middle school is putting on a big Fright Night celebration for Halloween. Lizzie wants to appear as Vampira, the dungeon mistress, but Kate is in charge and she keeps the job for herself, making Lizzie clean out the janitor's closet and then giving her the role of a clown handing out balloons. Miranda brings her parents, who are helping her celebrate a Mexican holiday, the Day of the Dead. They bring by several items including skulls and skeletons which are meant to represent ancestors who are being honored. Kate is all smiles when Miranda's parents are around (""Toon Lizzie"" calls Kate ""phonier than cafeteria cheese""), but once they leave she yells at Miranda to get rid of that junk they brought. Miranda warns Kate that by disrespecting the dead, she is risking their wrath.

Lizzie and her mom become best friends after reading a book in social studies.

Miffed with her parents for not raising her allowance, Lizzie gets her first job as a busboy at the Digital Bean.

Lizzie wants to be voted "best dressed" in her school and wants to buy an expensive pair of jeans, but her Mom refuses and insists on buying her clothes at discount store.

Frankie Muniz visits, which puts a strain on Lizzie's friendship with Miranda and Gordo.

Kate's having a big birthday party and she invites everyone from her class, including Lizzie, Miranda and Gordo. But Lizzie and Miranda's parents refuse to let them go to the party as there would be no adults around. So, Lizzie, Miranda and Gordo lie to their parents and go to the party anyway.