Lizzie tries out for cheerleader but doesn't do very well. Later that night she and Miranda chat online. Lizzie jokes that Kate made the squad because she stuffs her bra. Miranda accidentally sends out the message to everyone on the class roster. The next day at school Kate is furious about the taunting she's receiving and confronts Lizzie and Miranda, demanding to know who is responsible. Lizzie stutters and stammers for a few moments, then Miranda says that she did it. Kate promises to make her life miserable, and a war of dirty tricks breaks out between the two. Miranda tells Lizzie that she took the blame because Lizzie can't handle conflict. Lizzie feels guilty as the war between Miranda and Kate escalates. Finally Lizzie works up the nerve to take responsibilty for the message and she stands up to Kate. Also, Matt brings home a lizard for a school project and names it Lizzie, much to his sister's annoyance. While Mr. and Mrs. McGuire are supposed to be watching the lizard, it die

Lizzie, Miranda and Gordo all have big problems on the day their pictures are to be taken for the junior high yearbook. Lizzie searches and searches for the right thing to wear, but her mother insists she put on a ""hideous"" sweater that her grandmother gave her. Miranda runs afoul of Kate when they both show up wearing the same outfit. And Gordo feels the pressure to assume a tough-guy pose when his picture is snapped. Meanwhile Matt hasn't studied for a quiz at school, so he fakes being sick to get out of it. But he finds out that his mom's cure can be worse than the disease.

Lizzie is looking forward to the science class field trip, but she is mortified when she finds out that her mother is a last-minute replacement as the girls' chaperone. Lizzie fears that her mother will embarrass her to death, and Mom does a pretty good job of doing just that while they are competing with the boys on a nature walk. But Mrs. McGuire proves how cool she can be when she helps the girls get back at the boys for a prank they pulled then takes all the blame herself. Back at home, Matt and Mr. McGuire are left on their own and try to cook for themselves.

Lizzie and Miranda are ecstatic about being invited to a pool party given by their heartthrob, Danny Kessler. Mrs. McGuire is excited for Lizzie too until she finds out it's on the same day as grandma's 80th birthday party. She tells Lizzie she has to go to her grandma's instead and Lizzie is furious. The next day at school Miranda temporarily gets on the good side of Kate, the girls' former best friend who has literally and figuratively outgrown them. Kate invites Miranda to hang out with her crowd, causing a conflict between Miranda and Lizzie. At home Lizzie catches her mom on the phone making up a lie to get out of a commitment and accuses her of being a hypocrite. Gordo helps Lizzie to smooth over her differences with Miranda. Mom tells Lizzie she can go to the party after all, but she decides not to and spends the day with Gordo.

Lizzie is dissatisfied with being an ordinary ""B"" student and is looking for something at which she can excel. Surprisingly, she finds out in gym class that she has a real talent for rhythmic gymnastics. But she thinks the sport is stupid and is ambivalent about competing. She trains hard and goes to the regional competition, where a jealous Kate tries to sabotage her performance. Miranda and Gordo help foil Kate's plan and Lizzie wins first place. Her parents are proud but Lizzie decides to give up the sport and go back to being her ""ordinary"" self.

Gordo is sure that Mr. Pettus is giving him ""B""s instead of ""A""s because Pettus doesn't like him. His state of mind isn't helped any when the teacher gives the class an aptitude test which shows that Gordo is best suited to be a blackjack dealer. To prove that Mr. Pettus has it in for him, Gordo convinces Lizzie to turn in his science project with her name on it and vice versa, which ends up having disasterous results. Also, Matt adopts a hip-hop attitude and insists that everyone call him ""M-Dogg.""

Lizzie and friends are frustrated--the only candidates for school president are super-popular cheerleader Claire Miller and oddball Larry Tudgeman, who promises to eat a worm for every vote he gets. Gordo encourages Lizzie to run as a ""normal"" candidate and Miranda seconds the motion. Lizzie agrees to do it. Gordo is her gung-ho campaign manager as she runs on a ""voice of the people"" platform. Lizzie starts to gain confidence, even enough to tell off Claire and Kate. Gordo thinks she should schmooze the ""second-tier"" popular kids in the drama club, so Lizzie puts on her shades and black leather and tries to get in good with them. Miranda is annoyed that Lizzie is blowing off the less popular kids and groups to hang with the drama club. Lizzie starts to develop a prima donna attitude and now Gordo has to agree that he has helped create a monster in candidate Lizzie.

Mrs. Stebel pairs up the students in her social studies class for a mock marriage assignment. Each set of partners must draw a job from a jar at random, work up a fictional lifestyle and report back at a pretend 20-year reunion. Always-snobby Kate is horrified to find herself matched up with Larry Tudgeman, but at least she likes her job, a television anchorwoman. Lizzie wants to be partnered with Ethan Craft, who's not so smart but is cute. But she gets familiar old Gordo, whose job is sanitation engineer (garbageman). Lizzie figures it's not so bad, though, since Gordo will probably ensure she gets a good grade. Her mind begins to change when Miranda gets picked to be Ethan's partner, and he's a surgeon to boot. Lizzie can't help but be jealous.

Lizzie falls in with a bad crowd when she befriends "bad girl," Angel, at school.

Lizzie meets Ronnie, a paper boy. She falls for him, and gets a series of firsts. First love, kiss, and heartbreak.

As Lizzie and her friends get ready for graduation, Gordo tries to figure out the perfect thing to write in her yearbook.

Lizzie starts a column on her school's website, but soon finds it difficult to handle when her good intentions backfire.

Lizzie is invited to play touch football with the guys, but she is worried when Ethan calls her a "dude," and she feels that she is losing her femininity by playing football.

Lizzie and Gordo worry about Miranda's diet; Matt expresses interest in the fine arts.

Lizzie's friends and family play a murder mystery party game at her house.

Lizzie tries to get all eleven of her pictures in the school yearbook, but Kate has other plans.

Parker, a girl that Gordo likes, turns down his offer to go with him to the school dance because of his height.

Lizzie, Miranda, and Gordo go to see their childhood favorites Clover and Daisy live, keeping it hush so no one from school will find out-only to be shocked when the most popular girl in school is there on a babysitting job. Lizzie and friends remember that sometimes it's great, just to be silly, willy, nilly, and extaslopadily. Meanwhile Matt comes up with a dirty scheme to make money.

Lizzie and Matt switch bodies for a day, a la Freaky Friday. Matt (in Lizzie's body) and Lizzie (in Matt's body) go to each other's school and end up in amusing situations.

Lizzie wants to be voted "best dressed" in her school and wants to buy an expensive pair of jeans, but her Mom refuses and insists on buying her clothes at discount store.

Lizzie begins mentoring a seventh-grader girl named Andie, who begins to mimic her characteristics and behave like Lizzie.

Lizzie and her mom become best friends after reading a book in social studies.

Miffed with her parents for not raising her allowance, Lizzie gets her first job as a busboy at the Digital Bean.

While Lizzie and Kate are stuck working together for the Spring Fling committee, Lizzie sees Kate knock over the bust of the school's founding principal. When Principal Tweedy discovers this, he cancels the Spring Fling unless the person responsible comes forward.

Frankie Muniz visits, which puts a strain on Lizzie's friendship with Miranda and Gordo.