Lizzie meets Ronnie, a paper boy. She falls for him, and gets a series of firsts. First love, kiss, and heartbreak.

As Lizzie and her friends get ready for graduation, Gordo tries to figure out the perfect thing to write in her yearbook.

Lizzie starts a column on her school's website, but soon finds it difficult to handle when her good intentions backfire.

Lizzie's friends and family play a murder mystery party game at her house.

Lizzie is invited to play touch football with the guys, but she is worried when Ethan calls her a "dude," and she feels that she is losing her femininity by playing football.

Gordo and Miranda visit Lizzie after she was out sick and bring her some scary news--in social studies class she has to pair up on a project with---KATE!! Lizzie reacts hysterically. She tries to get out of going to class the next day but her parents make her go. Kate is mad about working with Lizzie also, but she comes by the McGuire house to work on their project, cooking a Latvian dish called an Alexander Tort (a raspberry pastry ). At first the two are hostile to each other, but eventually they have a laugh or two and begin to recall the days when they were friends. Jo McGuire sees them enjoying themselves and tells the girls it seems like old times. Suddenly the girls stop being so friendly, then Kate excuses herself and leaves. At school Miranda and Gordo ask Lizzie how it went with Kate, expecting the worst. Lizzie says it wasn't so bad. In fact, the two are going to the Digital Bean to do work on a high-speed computer. When they get there, Kate and Lizzie are working fine, but

Lizzie and Gordo worry about Miranda's diet; Matt expresses interest in the fine arts.

Lizzie, Miranda, and Gordo go to see their childhood favorites Clover and Daisy live, keeping it hush so no one from school will find out-only to be shocked when the most popular girl in school is there on a babysitting job. Lizzie and friends remember that sometimes it's great, just to be silly, willy, nilly, and extaslopadily. Meanwhile Matt comes up with a dirty scheme to make money.

Lizzie and Miranda are ecstatic about being invited to a pool party given by their heartthrob, Danny Kessler. Mrs. McGuire is excited for Lizzie too until she finds out it's on the same day as grandma's 80th birthday party. She tells Lizzie she has to go to her grandma's instead and Lizzie is furious. The next day at school Miranda temporarily gets on the good side of Kate, the girls' former best friend who has literally and figuratively outgrown them. Kate invites Miranda to hang out with her crowd, causing a conflict between Miranda and Lizzie. At home Lizzie catches her mom on the phone making up a lie to get out of a commitment and accuses her of being a hypocrite. Gordo helps Lizzie to smooth over her differences with Miranda. Mom tells Lizzie she can go to the party after all, but she decides not to and spends the day with Gordo.

Lizzie and Matt switch bodies for a day, a la Freaky Friday. Matt (in Lizzie's body) and Lizzie (in Matt's body) go to each other's school and end up in amusing situations.

Lizzie wants to be voted "best dressed" in her school and wants to buy an expensive pair of jeans, but her Mom refuses and insists on buying her clothes at discount store.

Lizzie begins mentoring a seventh-grader girl named Andie, who begins to mimic her characteristics and behave like Lizzie.

Lizzie tries to get all eleven of her pictures in the school yearbook, but Kate has other plans.

Parker, a girl that Gordo likes, turns down his offer to go with him to the school dance because of his height.

Lizzie and friends are frustrated--the only candidates for school president are super-popular cheerleader Claire Miller and oddball Larry Tudgeman, who promises to eat a worm for every vote he gets. Gordo encourages Lizzie to run as a ""normal"" candidate and Miranda seconds the motion. Lizzie agrees to do it. Gordo is her gung-ho campaign manager as she runs on a ""voice of the people"" platform. Lizzie starts to gain confidence, even enough to tell off Claire and Kate. Gordo thinks she should schmooze the ""second-tier"" popular kids in the drama club, so Lizzie puts on her shades and black leather and tries to get in good with them. Miranda is annoyed that Lizzie is blowing off the less popular kids and groups to hang with the drama club. Lizzie starts to develop a prima donna attitude and now Gordo has to agree that he has helped create a monster in candidate Lizzie.

Lizzie falls in with a bad crowd when she befriends "bad girl," Angel, at school.

Gordo, always the nonconformist, has a new passion: 1950s & '60s Las Vegas lounge culture, as epitomized by Frank Sinatra and the ""Rat Pack."" Lizzie and Miranda don't care for it, but they buy Gordo a Rat Pack CD. Ethan Craft listens to it on the bus and, surprisingly, likes it, which makes the girls reconsider their opinion. Soon they are dressing in fashions of the time. Gordo thinks it's cool that they like it, but hopes that his new interest won't become the latest passing fad at school. But that looks like exactly what is happening as Ethan soon has all the guys wearing hats like Sinatra and listening to the music. Even Kate is admiring the girls for being in first on the new trend and actually asks for their advice on what to do!

Lizzie's fantasy almost comes true when she is paired up with Ethan Craft in a CPR class at school, but he's so dense that the teacher chooses Tudgeman instead to give Lizzie mouth-to-mouth! Lizzie, Gordo and Miranda realize they are about the only three in school who haven't seen the latest blockbuster movie Vesuvius: The Eruption, which is rated R, and they're determined to get in to see it. When their parents all say ""no"" to their arguments, Gordo decides they should say they are going to play miniature golf, then go see the film. Lizzie is very nervous about lying to her parents, but she pulls it off with ease. The trio can't get past the ticket-taker, though, and can't slip in the back, so they mingle with the crowd as it is departing a showing and sneak in that way. While at the concession stand, they notice a man choking.

Lizzie auditions to be in a fashion show presented by "Teen Attitude" magazine at a local mall and she gets accepted. At the show Lizzie looks great on the stage. Afterward, popular girl Jessica asks Lizzie to come to a party at her country club. Lizzie gets Miranda and Gordo invited also. At the party, all three are enjoying the fun, including the hot tub. But already Lizzie's friends are acting different. When Jessica asks her about coming to another party, Miranda starts answering for Lizzie like a press agent and she and Gordo start negotiating future appearances for her like a supermodel! At school things are very different, also. Kids stare at her in the hall like she's a celebrity. Kate is now fawning all over Lizzie, wanting to be her friend. Ethan is so starstruck that he can't even mumble a coherent sentence around her. Gordo and Miranda are as bad as anybody. Lizzie muses, "Gordo and Miranda aren't my friends anymore. They're my people!"

The middle school is putting on a big Fright Night celebration for Halloween. Lizzie wants to appear as Vampira, the dungeon mistress, but Kate is in charge and she keeps the job for herself, making Lizzie clean out the janitor's closet and then giving her the role of a clown handing out balloons. Miranda brings her parents, who are helping her celebrate a Mexican holiday, the Day of the Dead. They bring by several items including skulls and skeletons which are meant to represent ancestors who are being honored. Kate is all smiles when Miranda's parents are around (""Toon Lizzie"" calls Kate ""phonier than cafeteria cheese""), but once they leave she yells at Miranda to get rid of that junk they brought. Miranda warns Kate that by disrespecting the dead, she is risking their wrath.

While Lizzie and Kate are stuck working together for the Spring Fling committee, Lizzie sees Kate knock over the bust of the school's founding principal. When Principal Tweedy discovers this, he cancels the Spring Fling unless the person responsible comes forward.

Gordo skips a grade and gets promoted to high school. After initial euphoria, Lizzie and Miranda start to miss Gordo.

Kate's having a big birthday party and she invites everyone from her class, including Lizzie, Miranda and Gordo. But Lizzie and Miranda's parents refuse to let them go to the party as there would be no adults around. So, Lizzie, Miranda and Gordo lie to their parents and go to the party anyway.

Lizzie and Miranda note that when a girl gets her first bra, her personality somehow seems to change. They decide they are ready for their first, and hatch a plan to get Lizzie's mom to take them to the mall where they will shop for ""school supplies."" Lizzie is a terrible liar, though, and blurts out the real reason for the trip. Mom is overjoyed to help the girls out, but she embarrasses them as they are shopping. Lizzie is very harsh with her mother, telling her that she and Miranda are old enough to do their own shopping and to leave them alone. The girls face further embarrassment when they run into Kate, Claire, and their English teacher Mr. Coppersmith. They also find that they don't know what to look for.

Matt is irritating Lizzie with his magic tricks while she's trying to do homework. Soon they are fighting like cats and dogs--or brother and sister--much to the annoyance of their parents. But as soon as Sam and Jo stop them, they go right back to fighting. At school Ethan Craft speaks to Lizzie and Miranda, but Lizzie is so tongue-tied she can barely utter a word. Mr. Escobar announces a charity drive and asks for volunteers. Lizzie thinks she'll be too busy until she hears that Ethan will be there. At home Lizzie is making some cookies for the event when Matt tries out another trick. This time he handcuffs himself to his sister, but he can't get the cuffs loose. Mom spies the key and hides it, thinking that if the kids are forced to spend a few hours chained together, they might learn to get along better. Now Lizzie is facing the horror of going to the charity drive with her little brother stuck on her arm!