MacGyver is forced out of his grief over the tragic death of a friend by a madman with a score to settle from their past association.

MacGyver heads up a trip with four other Phoenix Foundation employees into the wilderness as part of a stress reduction program. After discovering that a prison bus accident has freed several prisoners, the employees begin to question each other's behavior. MacGyver must now figure out which man, if any, is not to be trusted before it's too late.

MacGyver and Pete meet at a wrecking yard, both thinking that the other one arranged the meeting. Soon an unknown assailant captures them inside a big truck. Their only clue is an obituary for them and Jack Dalton.

Penny Parker's big chance in a major professional role is threatened from two directions: a money shortage and several deaths linked to the musical she is set to perform in.

An old nemesis enlists MacGyver's help to rescue someone important to him—and she's scheduled to be executed during a Halloween Party put on by a professional assassination organization.

A mysterious person who calls himself "Viking" has just bombed the cruise ship Victoria, underway in the North Pacific Ocean. He demands six million dollars or another bomb will go off within hours. So MacGyver gets called in, along with his old Vietnam bomb-defusal partner, Charlie Robinson, to disarm it. But when they get there, they find out there's more than one bomb on the ship. Complications arise when MacGyver's partner sets off one of the bombs, and the bomber decides that DXS operated in bad faith and refuses to hand over the bomb-disarming instructions after he gets the extortion money.

While retrieving tickets for a hockey game at the Phoenix Foundation, MacGyver and his grandpa Harry get caught in the middle of a woman's plot to blow up the building using a bomb that she herself made. They try to escape, but are locked in. Now they must figure another way out before she activates the bomb.

A desperate physics student goes off the deep end and boobytraps a college lab when he fails to win a science competition and to live up to his father's high expectations.

Posing as a watchmaker who manufactures bomb timers, MacGyver manages to catch a master killer—Piedra—before he attempts an assassination on a high-profile target. However, Piedra isn't about to be stopped for long.

MacGyver and Pete are testing a new security system at the Strategic Research Development Administration. MacGyver successfully bypasses the security and meets Dr. Jill Ludlam, the system's designer. She tries to turn off the security system, but it doesn't realize that it was just a test. MacGyver and Dr. Ludlam are then forced to find a way out, as the security system, named Sandy, tries to destroy the "intruders."

MacGyver becomes infatuated with a woman while conducting environmental-impact studies. However, what MacGyver does not know is that the woman was hired to "persuade" him to skip the studies—and if necessary, kill him.

MacGyver accompanies Penny Parker to an old house she inherited from her Aunt Betty, who mysteriously died 30 years before. When strange things start happening, Penny is sure that the house is haunted.

MacGyver and an old friend dash around the world searching for the artifacts necessary to locate the Holy Grail, just one step ahead of a ruthless man on the same trail.

Frantic with worry about his gravely-ill Grandpa Harry, MacGyver experiences a strange near-death phenomena, seeing his parents again, when he's injured by a man who's stolen an ancient Egyptian relic.

While working with Chinese dissidents to expose illegal labor camps, MacGyver gets unexpected help from a young photojournalist who claims to be his son!

When a science lab studying the ozone layer mysteriously explodes, MacGyver is called in to rescue the scientists that are trapped underground. It's soon discovered that the explosion cracked a tank of sulfuric acid, and MacGyver is in a race against time before the Army uses a missile to seal up the base.

While mapping the wilderness for the Phoenix foundation, MacGyver stumbles on a deserted ship and finds a runaway girl who tells him that the rest of crew was driven away by Bigfoot.

MacGyver gets involved in the search for an escaped serial killer. Soon he comes to the conclusion that the killer had help from another prisoner—an even more sinister man.

During some tough negotiations between two neighbouring states, one side plants a sniper in the vicinity. When Mac discovers the sniper, he fights him, but loses the man and the accusations go out against Mac. Wounded and forced to run, he hides at a private girls' school, where one of the young ladies becomes his only hope to prevent further bloodshed.

Dr. Zito returns to menace MacGyver and Murphy when he escapes after his latest sanity hearing, leaving a series of nasty clues designed to give Mac a crash course in evil.

After blowing away a nuclear facility under the control of an aggressive world leader, MacGyver returns home for some peace and quiet, only to find his boss waiting for him. He advises MacGyver that a contract is out on his life and he needs to skip town for awhile.

A retired actor and his wife stop at a motel on the way to Los Angeles. MacGyver rescues them from a drunkard who nearly makes a mark on their car. MacGyver is supposed to meet a mobster-turned-informant at the motel, but the meeting goes wrong. The mob shows up and kills MacGyver's friend before he can give MacGyver what he promised. Instead the bag lands in the old couple's car, where the old actor finds it and discovers it full of money.

While on assignment to test field agents for the Phoenix Foundation, MacGyver and Pete discover the wreckage of a DEA plane shot down by dangerous drug smugglers.

MacGyver and an old friend dash around the world searching for the artifacts necessary to locate the Holy Grail, just one step ahead of a ruthless man on the same trail, who will do anything to get to it before they do.

Murdoc wants to come out of retirement, but his former employers at Homicide International request that he take out MacGyver as a demonstration of his sincere desire to rejoin them.