When MacGyver comes face to face with Murdoc, an international assassin hired to kill him, Mac must defend both himself and Bozer, armed with only a corkscrew and paper towel rolls. Also, Bozer feels completely betrayed when he finally learns Mac's true identity.

Using a screwdriver and bug spray, MacGyver must find the U.S. government mole who is leaking classified intel to the organization that is trying to take down The Phoenix Foundation. Also, Sarah returns to help with the mission, and Nikki reappears, but Mac can’t tell which side she’s on.

Mac and the team have no time to reminisce while visiting Mac’s and Bozer’s hometown when they immediately start searching for a kidnapped prodigy from Mac’s old middle school, Valerie.

Using a fish scaler and some fishing wire, Mac and Jack must track down a corrupt FBI agent who has framed a man for murder. Also, everyone on the team is terrified to get their first performance review from Matty, their tough new boss.

Using only a wrench and rope, MacGyver must diffuse a bomb set near the United Nations by his old nemesis, “The Ghost”, a notorious criminal whose work killed his mentor, and track him down before he strikes again.

MacGyver is tasked to go undercover as an inmate in a maximum security prison to break out El Noche, a notorious drug kingpin, using only batteries and salt, and track him to his cartel's secret location and dismantle it.

While tracking down the dangerous fugitive Aaron Deckard, Mac and Jack face the notorious Colton family of bounty hunters who already kidnapped their mark. Also, Bozer and Riley try to hack into Jack’s CIA file to find out about his history with Matty.

When Mac and the team travel to Hawaii to aid in earthquake relief efforts, they team up with Chin and Kono from the Five-0 task force to rescue a group of government scientists trapped in a building. However, as they work on the complicated rescue, a group using the chaos as a distraction aims to steal the top-secret weaponry from the scientists.

An international crime boss offers Matty a deal she can’t refuse – he’ll surrender himself into her custody if he’s allowed to return to the United States to watch his daughter walk down the aisle. MacGyver and team crash the wedding to ensure the crime lord doesn’t run, only to discover they’re not the only ones lying in wait at the event.

When Mac and Jack are trapped inside Mac's house, which his nemesis, The Ghost, has rigged with explosives, Mac uses a karaoke mic and an audio transformer to let the team know that this bomb is a distraction for a bigger one. Also, through flashbacks, Mac and Jack's contentious first meeting unfolds.

When Nicholas Helman resurfaces to carry out a killing spree, the Phoenix is forced to get help from the one person who knows him best… his protégé, Murdoc.

Using a cryptic postcard as their only clue, Mac and the team must solve a fallen friend’s final case and bring him justice.

With only a chisel and matchbook, MacGyver and team must defend themselves the U.S. embassy workers in Latvia from extremists who are attempting to retrieve their leader. Also, Bozer faces a big decision now that he knows who Mac really is.

MacGyver and Jack search for Riley, using a microwave and a power strip, after she mysteriously disappears and hacks into the NSA, possibly unleashing World War III. Also, Bozer goes on his first official mission, and Jack opens up about his history with Riley’s mother, Diane.

On the way back from capturing a war criminal, Mac and Jack’s helicopter crashes in a remote area of Kazakhstan, injuring their pilot and allowing their prisoner to escape with Jack’s gun. Using a large blade and a water bottle, MacGyver must get help as the pilot’s condition worsens and before the war criminal takes them as prisoners.

When the team intercepts a terror group’s message meant for Murdoc, Mac poses as the psychopath to save the intended target and find out why they want Murdoc to assassinate him.

Murdoc moves forward with his plans for revenge against MacGyver by recruiting his recently released former cellmate to infiltrate the Phoenix Complex as a “lab technician” and kill every agent inside.

When 32 college students are stranded on a research ship in the Arctic Ocean with no heat and erupting fires, Mac develops an emotional connection to the group leader, via video chat, as he relays how to stay alive as they await a rescue ship. Also, Jack kidnaps Elwood to find out what scam he’s up to next, and Bozer’s feelings toward Leanna grow stronger.

Murdoc abducts MacGyver’s girlfriend, Nasha, to force Mac to help him rescue his son, Cassian, from a kidnapper. Also, a dangerous individual from Murdoc’s personal life shows up, giving Mac a glimpse into the villain’s past.

When MacGyver takes Riley and Bozer into the wilderness for a weekend of survival training, things take a turn when they run into a violent group of criminals who are searching the rugged backcountry for a lost crate of money. Also, Jack and Matty go on a road trip to place Matty’s ex-husband and his family in witness protection.

MacGyver faces off with a cunning new adversary whose carefully crafted plans put Mac at the epicenter of an impossible choice: save the life of a friend, or save the lives of hundreds of innocents. Also, Mac receives new information that will drive a wedge between him and his father.

After Oversight is almost killed in a bombing, he recruits Mac to help him find the suspected bomber, Mason. However, when Mason reveals he didn’t plant the bomb, the three team up to track down Codex, the shadow organization that set them up. Also, Mac meets his aunt Gwendolyn.

Mac's meeting with Desi's parents goes sideways when her brother finds himself in trouble and desperately needs their help. Also, Russ and Matty must ask an old nemesis for assistance when their new recruitment candidate is kidnapped.

While on a mission to hunt down a Codex lead, Mac and the team discover Murdoc hacked their comms and has recorded them for months. Now, Mac and the team must stop Murdoc, who is working with Andrews, as they plot to kill thousands and reveal each Phoenix member’s most-guarded secrets.

The LAPD interrupts the team’s Christmas celebration to arrest Mac for terrorism when they find a body in a building destroyed by a bomb Mac built.