Angus MacGyver and Jack Dalton, special agents for the Department of External Services (DXS), join forces to recover a missing bioweapon that has the ability to destroy hundreds of thousands of people with one single drop.

MacGyver and the team attempt to rescue Sarah, Jack’s former CIA partner/ex-girlfriend who went missing in Venezuela after she obtained evidence to take down an international arms dealer.

MacGyver and the team are in Malaysia to extract a terrorist groups’ money man, Ralph, who holds key intel to an impending attack. But the mission goes south when the man is shot, and now, with only a driver’s license and hand sanitizer available, MacGyver must keep Ralph alive in order to learn the terrorists’ plans.

Mac and Jack partner with older versions of themselves, a Russian bomb programmer and his estranged handler, to shut down a Soviet-era warhead in Moscow. But when the antiquated computer needed to disable the warhead becomes inoperable, Mac must find a way to fix it with only duct tape and wire in time to prevent a new Cold War.

Using only an armrest, a curtain rod, and a toothpick, MacGyver must fix a sabotaged train in order to protect a whistleblower who has proof that her boss is selling weapons to U.S. enemies.

With only a chisel and matchbook, MacGyver and team must defend themselves the U.S. embassy workers in Latvia from extremists who are attempting to retrieve their leader. Also, Bozer faces a big decision now that he knows who Mac really is.

Using a cell phone and soccer ball, MacGyver and the team search for a Navy SEAL who is believed to be alive in captivity in the Middle East.

On the way back from capturing a war criminal, Mac and Jack’s helicopter crashes in a remote area of Kazakhstan, injuring their pilot and allowing their prisoner to escape with Jack’s gun. Using a large blade and a water bottle, MacGyver must get help as the pilot’s condition worsens and before the war criminal takes them as prisoners.

Using only a wrench and rope, MacGyver must diffuse a bomb set near the United Nations by his old nemesis, “The Ghost”, a notorious criminal whose work killed his mentor, and track him down before he strikes again.

MacGyver is tasked to go undercover as an inmate in a maximum security prison to break out El Noche, a notorious drug kingpin, using only batteries and salt, and track him to his cartel's secret location and dismantle it.

Mac and the team have no time to reminisce while visiting Mac’s and Bozer’s hometown when they immediately start searching for a kidnapped prodigy from Mac’s old middle school, Valerie.

Using a fish scaler and some fishing wire, Mac and Jack must track down a corrupt FBI agent who has framed a man for murder. Also, everyone on the team is terrified to get their first performance review from Matty, their tough new boss.

While tracking down the dangerous fugitive Aaron Deckard, Mac and Jack face the notorious Colton family of bounty hunters who already kidnapped their mark. Also, Bozer and Riley try to hack into Jack’s CIA file to find out about his history with Matty.

MacGyver and Riley, with the help of Vasil, a distraught father, must find a way to drive a tanker filled with liquid oxygen through a region occupied by rebels and deliver it to a children’s hospital before they run out. Also, Riley helps MacGyver decide whether or not to allow his father back into his life.

During COVID-19’s first stay-at-home order, as Mac, Bozer and Riley quarantine together, they try to stop a crime in progress at their neighbor’s house. Also, Russ’ romantic fling takes on a longer and more complicated turn when they quarantine together.

Mac and Riley head overseas together to prevent a governmental collapse and inadvertently inhale new deadly microscopic technology.

MacGyver and Jack search for Riley, using a microwave and a power strip, after she mysteriously disappears and hacks into the NSA, possibly unleashing World War III. Also, Bozer goes on his first official mission, and Jack opens up about his history with Riley’s mother, Diane.

Bozer’s first overseas mission goes terribly wrong when Mac and the team are blamed for a terrorist bombing and the Phoenix Foundation is forced to disavow them.

Using a necklace and a microwave transmitter, Mac and the team attempt to locate Riley after her first solo mission with a group of dangerous hackers goes off the rails

Using a cassette player and a plastic bucket, Mac and the team attempt to extinguish a massive oil wellhead fire in a Nigerian village, set by a rebel group, which is trying to topple its government by destroying their most valuable resource.

When Russ’ first love, Emilia, is kidnapped by the same rebels he fought during his private military contract days, he takes the Phoenix team to a small, impoverished town to rescue her and rid the town of the rebels for good.

When Russ is kidnapped, Mac and the team must break out a previously murderous psychopath, now pacifist, from prison to help find him. Also, while on the run, Mac and Desi are forced to confront their relationship issues.

When MacGyver comes face to face with Murdoc, an international assassin hired to kill him, Mac must defend both himself and Bozer, armed with only a corkscrew and paper towel rolls. Also, Bozer feels completely betrayed when he finally learns Mac's true identity.

Using a screwdriver and bug spray, MacGyver must find the U.S. government mole who is leaking classified intel to the organization that is trying to take down The Phoenix Foundation. Also, Sarah returns to help with the mission, and Nikki reappears, but Mac can’t tell which side she’s on.

When Matty’s goddaughter and her boyfriend are killed in a San Francisco park, Mac and the team investigate the crime and start to suspect that the 1970s Zodiac Killer has returned.