When the upcoming marriage of two star-crossed lovers from Colombia is in jeopardy, Elizabeth works to reunite the son of the Colombian president and the daughter of the rebel leader, whose union is at the heart of an important peace deal after years of civil war. Also, Henry prepares to send his operative undercover, Jay deals with his tenuous marital situation, and Daisy makes a shocking discovery regarding Kevin.

Elizabeth is shocked when the Philippines' unconventional new president, Datu Andrada, makes a pass at her during their meeting to discuss his refusal to participate in an Asia-Pacific territory treaty. Also, Elizabeth asks Jay to look into Kevin Park's CIA connections, and Henry fears for his operative who is embedded in the religious cult when he goes radio silent.

Elizabeth’s landmark global climate treaty with more than 200 countries is jeopardized when China threatens to back out due to her meeting with an ailing Dalai Lama. Also, Henry worries about his undercover operative’s safety, and Jay is surprised when Abby serves him with a custody agreement for their daughter.

When a computer sting uncovers the possible mole in the CIA arms smuggling ring, Elizabeth’s questioning of the suspect makes her think that a larger, more dangerous force is behind the operation. Also, Henry worries that the doomsday cult is drugging his embedded operative, and Elizabeth and her State Department staff come up with an unorthodox approach to solving black rhino poaching in Namibia.

When warring rebel groups threaten Elizabeth’s Somalian food relief efforts and kidnap an American aide there, she reluctantly considers asking a notorious Russian arms dealer for help. Also, Henry is blindsided when he is taken off the VFF doomsday cult case, and Alison and Stevie await their college acceptances.

As the U.S. hunts for the person believed to be behind the CIA arms smuggling case, Elizabeth and her team must work to save Jay when he’s kidnapped in Nice, France, during a fact-finding mission into the suspect. Also, Henry suspects the doomsday cult is planning an attack in Israel, and Jason dupes his parents into giving him money for an expensive calculator when he’s really using it to impress a girl.

Elizabeth and her team work to secure the release of an American journalist held hostage in the Sudan.

As Elizabeth and President Dalton head to Rome for the G20 Conference, she is concerned for Henry’s safety when he is sent to Israel to intercept the doomsday cult’s bio-weapon before it is deployed. Also, Blake reveals a personal secret to his former colleagues that he meets at the conference, and Elizabeth goes behind Stevie’s back to ask Russell to get her off Harvard Law School’s waiting list.

Elizabeth heads to Brussels to seek NATO’s support against Russia when it threatens to invade Bulgaria, but when France refuses to cooperate, it could threaten the alliance’s very existence. Also, Henry’s new government role has him dive into the Russia issue and turn to his former operative, Dmitri Petrov for help, and as Nadine and Mike B’s relationship heats up, Elizabeth finds out information about her old friend that makes her question his loyalties.

When U.S. intelligence locates the mastermind behind a foreign country's hack, Elizabeth must decide whether to risk war by extracting him from the country while she also prepares for the White House correspondents' dinner. Also, Jason faces backlash after he confronts his school newspaper over its coverage of Elizabeth.

When an American tech CEO goes missing in a foreign country, Elizabeth navigates complicated diplomatic terrain to get him back without triggering a regional conflict. Also, things get personal when Stevie and Henry testify at House impeachment proceedings.

Elizabeth faces a national security crisis when a military conflict in international waters spirals to the brink of nuclear confrontation. Also, with the imminent threat of impeachment looming over the McCord administration, Elizabeth and Henry make a wish-list of things to do while she’s still in office.

President Elizabeth McCord kicks off a new landmark political initiative with help from members of the World Cup Champion U.S. Women’s Soccer team. Also, the McCords overcome last-minute obstacles to pull off a spectacular family celebration.

After a bombing at a political rally in Angola, Elizabeth must find a way to respond to a “dissent memo” from the Bureau of African Affairs when they criticize the Dalton Administration’s lack of attention to the upcoming Angolan election.

When a possible Israel-Iran war threatens the House’s imminent vote on the U.S. presidential election, Elizabeth attempts to bring the two reluctant countries to the negotiation table in an effort to broker a peace between them. Also, Russell’s life hangs in the balance after a heart attack.

Elizabeth enlists the help of Hollywood star Ashley Whittaker to help sway the president of Kyrgyzstan to end human trafficking in his country, but the added attention could put an American captive at risk. Also, when Henry finds the bomb that’s being held by the doomsday cult, he uncovers information that they could be planning a deadlier attack.

Jay and Kat devise a way to help persecuted foreign LGBTQ citizens escape their country while their U.S. homeland security applications are processed. However, when the country closes its borders, Jay and Kat are forced to change that plan quickly, as it could now threaten their relationship with neighboring allies.

After U.S. environmental activists protesting China’s damage of a South China Sea reef are arrested for spying, Elizabeth finds herself in a stalemate with the Chinese foreign minister as she lobbies for their release.

As President Dalton eagerly awaits voting results on Election Day, Elizabeth uncovers information that could put the U.S.’s peace deal with Iran in jeopardy.

When Elizabeth and her staff fly to Africa to offer development aid to the continent, they are caught by surprise when the Chinese arrive there first, ready to outmaneuver the U.S. with competing offers of aid. Also, when turbulence on their plane ride to Africa leaves Daisy unnerved, she and Susan Thompson go on a welcome tour of Africa, admiring the beauty of the continent. And, the FBI asks Henry to help investigate a Christian cult member who may have helped build the bomb used in the Illinois coffee shop attack.

When an influential rabbi organizing a symbolic Iran/Israel soccer game is killed, Elizabeth and Jay’s peace treaty plans for the two countries are jeopardized. Also, Elizabeth’s name is floated for a Nobel Peace Prize. Jay’s tireless work on the Iran/Israel peace deal strains his marriage. Daisy makes a connection with new work colleague, Kevin Park.

Elizabeth faces unexpected consequences when she makes a plea to the President to help with a dire situation in Western Africa.

A Chinese student comes between a peace treaty between Japan and China. Stevie and Alison continue to clash.

Elizabeth negotiate's with Iran over their nuclear program. Jason works with his Dad on a school report.

With Algeria on the brink of a civil war, Elizabeth delicately negotiates a regime change, but her plans go awry when Roy Curtis, the trusted U.S. Ambassador to Algeria, dies unexpectedly. Also, Henry fights to save religious antiquities in Algeria when he discovers they are being destroyed by Hizb al-Shahid.