After Elizabeth delivers her first speech to the United Nations General Assembly formally condemning the terrorist group Hizb-al Shahid, she discusses forming a coalition against them with the Russian Foreign Minister. However, the talks create a conflict of interest between Elizabeth and Henry, who is searching for a way to save Dmitri’s ill sister, Talia Petrov, from the Russian government.

When President Dalton gets word that the world’s most wanted terrorist, Jibral Disah, is hiding in Islamabad, he sends the “Murphy Station” – Henry, Jane and Jose – on a dangerous mission to eliminate the threat. Also, Elizabeth and Henry go to couples therapy.

When Elizabeth receives shocking news about an important political operative, she navigates a tricky political situation with President Dalton, who she learns may be considering replacing her as Secretary of State. Also, Stevie and Jareth get engaged.

When the upcoming marriage of two star-crossed lovers from Colombia is in jeopardy, Elizabeth works to reunite the son of the Colombian president and the daughter of the rebel leader, whose union is at the heart of an important peace deal after years of civil war. Also, Henry prepares to send his operative undercover, Jay deals with his tenuous marital situation, and Daisy makes a shocking discovery regarding Kevin.

Elizabeth is shocked when the Philippines' unconventional new president, Datu Andrada, makes a pass at her during their meeting to discuss his refusal to participate in an Asia-Pacific territory treaty. Also, Elizabeth asks Jay to look into Kevin Park's CIA connections, and Henry fears for his operative who is embedded in the religious cult when he goes radio silent.

Elizabeth’s landmark global climate treaty with more than 200 countries is jeopardized when China threatens to back out due to her meeting with an ailing Dalai Lama. Also, Henry worries about his undercover operative’s safety, and Jay is surprised when Abby serves him with a custody agreement for their daughter.

When a computer sting uncovers the possible mole in the CIA arms smuggling ring, Elizabeth’s questioning of the suspect makes her think that a larger, more dangerous force is behind the operation. Also, Henry worries that the doomsday cult is drugging his embedded operative, and Elizabeth and her State Department staff come up with an unorthodox approach to solving black rhino poaching in Namibia.

When warring rebel groups threaten Elizabeth’s Somalian food relief efforts and kidnap an American aide there, she reluctantly considers asking a notorious Russian arms dealer for help. Also, Henry is blindsided when he is taken off the VFF doomsday cult case, and Alison and Stevie await their college acceptances.

As the U.S. hunts for the person believed to be behind the CIA arms smuggling case, Elizabeth and her team must work to save Jay when he’s kidnapped in Nice, France, during a fact-finding mission into the suspect. Also, Henry suspects the doomsday cult is planning an attack in Israel, and Jason dupes his parents into giving him money for an expensive calculator when he’s really using it to impress a girl.

Elizabeth and her team work to secure the release of an American journalist held hostage in the Sudan.

As Elizabeth and President Dalton head to Rome for the G20 Conference, she is concerned for Henry’s safety when he is sent to Israel to intercept the doomsday cult’s bio-weapon before it is deployed. Also, Blake reveals a personal secret to his former colleagues that he meets at the conference, and Elizabeth goes behind Stevie’s back to ask Russell to get her off Harvard Law School’s waiting list.

Elizabeth heads to Brussels to seek NATO’s support against Russia when it threatens to invade Bulgaria, but when France refuses to cooperate, it could threaten the alliance’s very existence. Also, Henry’s new government role has him dive into the Russia issue and turn to his former operative, Dmitri Petrov for help, and as Nadine and Mike B’s relationship heats up, Elizabeth finds out information about her old friend that makes her question his loyalties.

Elizabeth must watch what she says and does when she deals with a refugee situation while being shadowed by Neal Shin, a newspaper reporter who may use his access to write a tell-all book.

When U.S. intelligence locates the mastermind behind a foreign country's hack, Elizabeth must decide whether to risk war by extracting him from the country while she also prepares for the White House correspondents' dinner. Also, Jason faces backlash after he confronts his school newspaper over its coverage of Elizabeth.

When an American tech CEO goes missing in a foreign country, Elizabeth navigates complicated diplomatic terrain to get him back without triggering a regional conflict. Also, things get personal when Stevie and Henry testify at House impeachment proceedings.

Elizabeth faces a national security crisis when a military conflict in international waters spirals to the brink of nuclear confrontation. Also, with the imminent threat of impeachment looming over the McCord administration, Elizabeth and Henry make a wish-list of things to do while she’s still in office.

President Elizabeth McCord kicks off a new landmark political initiative with help from members of the World Cup Champion U.S. Women’s Soccer team. Also, the McCords overcome last-minute obstacles to pull off a spectacular family celebration.

After a bombing at a political rally in Angola, Elizabeth must find a way to respond to a “dissent memo” from the Bureau of African Affairs when they criticize the Dalton Administration’s lack of attention to the upcoming Angolan election.

When a possible Israel-Iran war threatens the House’s imminent vote on the U.S. presidential election, Elizabeth attempts to bring the two reluctant countries to the negotiation table in an effort to broker a peace between them. Also, Russell’s life hangs in the balance after a heart attack.

Jay and Kat devise a way to help persecuted foreign LGBTQ citizens escape their country while their U.S. homeland security applications are processed. However, when the country closes its borders, Jay and Kat are forced to change that plan quickly, as it could now threaten their relationship with neighboring allies.

Elizabeth is attending a summit in Montreal to resolve territorial claims of the North Pole when an activist group detonates a bomb and she can’t locate Jason and Piper. Also, things take a turn for the worse when Elizabeth learns that Russia was involved in the bombing, and Henry helps one of his students work through a difficult decision.

Elizabeth enlists the help of Hollywood star Ashley Whittaker to help sway the president of Kyrgyzstan to end human trafficking in his country, but the added attention could put an American captive at risk. Also, when Henry finds the bomb that’s being held by the doomsday cult, he uncovers information that they could be planning a deadlier attack.

In the aftermath of a deadly attack on the White House, Elizabeth tries to keep a major nuclear disarmament deal from falling apart while a manhunt for the attackers brings D.C. to a halt. For advice, Elizabeth turns to former secretaries of state Madeleine Albright, Hillary Clinton and Colin Powell.

Elizabeth takes advice from former Secretary of State Madeleine Albright and ignores President Dalton's recommendation on how to negotiate the safe return of a Sate Department employee who was kidnapped in Afghanistan. Meanwhile, Henry is having trouble persuading a student to spy for the U.S. government.

As Elizabeth holds peace talks between the prime ministers of India and Pakistan, a mysterious plane crash tied to both countries causes the three parties to reevaluate the deal. Also, in an attempt to help the NSA locate the terrorist Jibral Disah, Henry approaches a former teacher of one of Disah’s wives for information, and Elizabeth withstands a grueling interview with Jane Pauley.