In the aftermath of a deadly attack on the White House, Elizabeth tries to keep a major nuclear disarmament deal from falling apart while a manhunt for the attackers brings D.C. to a halt. For advice, Elizabeth turns to former secretaries of state Madeleine Albright, Hillary Clinton and Colin Powell.

Jay and Kat devise a way to help persecuted foreign LGBTQ citizens escape their country while their U.S. homeland security applications are processed. However, when the country closes its borders, Jay and Kat are forced to change that plan quickly, as it could now threaten their relationship with neighboring allies.

Elizabeth faces unexpected consequences when she makes a plea to the President to help with a dire situation in Western Africa.

When the upcoming marriage of two star-crossed lovers from Colombia is in jeopardy, Elizabeth works to reunite the son of the Colombian president and the daughter of the rebel leader, whose union is at the heart of an important peace deal after years of civil war. Also, Henry prepares to send his operative undercover, Jay deals with his tenuous marital situation, and Daisy makes a shocking discovery regarding Kevin.

While Elizabeth works to successfully broker a peace treaty between China and Japan, a Chinese student seeking political asylum threatens the deal. Meanwhile, tensions rise at home between Alison and Stevie during Alison's sleepover party.

When Elizabeth faces the daunting task of negotiating with Iran over their escalating nuclear program, she is determined to deal with the situation in a peaceful manner, despite the President's position of using military action. Meanwhile, Jason has new admiration for his father when he interviews him for a school report.

Elizabeth goes head to head with a U.S. governor over the state’s new policy of separating unauthorized immigrants from their children.

A NATO ally carries out a state-sponsored assassination attempt against one of its own citizens, who is also a U.S. resident and old friend of Elizabeth’s. Also, Alison starts dating the son of one of Elizabeth’s political rivals.

As Elizabeth struggles to hold herself together emotionally following the attack in Iran, she works to prevent an ecological disaster in the Amazon, and prepares for a national television appearance on “Face the Nation.” Also, she and Henry disagree about the level of protection Jason should have at his new school.

As Elizabeth holds peace talks between the prime ministers of India and Pakistan, a mysterious plane crash tied to both countries causes the three parties to reevaluate the deal. Also, in an attempt to help the NSA locate the terrorist Jibral Disah, Henry approaches a former teacher of one of Disah’s wives for information, and Elizabeth withstands a grueling interview with Jane Pauley.

When warring rebel groups threaten Elizabeth’s Somalian food relief efforts and kidnap an American aide there, she reluctantly considers asking a notorious Russian arms dealer for help. Also, Henry is blindsided when he is taken off the VFF doomsday cult case, and Alison and Stevie await their college acceptances.

Elizabeth seeks creative solutions when the president of Sri Lanka's psychic convinces him to not move forward with a trade agreement with the U.S. Also, Alison grapples with guilt for missing the warning signs after her college roommate attempts suicide, and Henry makes an abrupt career decision.

Elizabeth and the team are caught in an uncertain situation when they are about to award a foreign leader with the Medal of Freedom but learn he may have known that a minority group in his country is being persecuted. Also, President Dalton doubts his ability to return to office after being cleared by his doctor, and a past family grievance is brought to light when Henry’s sister pays a visit.

Elizabeth’s negotiations for a security agreement combatting gang violence in South America becomes complicated when she attempts to free an American recently kidnapped there.

Elizabeth has to deal with a crisis in Yemen and there's trouble on the home front for her as well after her oldest daughter Stevie manages to make the headlines for protesting a new policy at her university.

When the President approves Henry's reactivation into the NSA, he decides to keep his continued involvement in the spy game a secret from Elizabeth. Meanwhile, Matt and Daisy's antagonism toward one another begins to affect the entire office.

Elizabeth, Henry, and Isabelle investigate a plane crash that killed former Secretary of State Vincent Marsh. Nadine reenters the dating scene after she agrees to go on a date with a NASA scientist.

Elizabeth and President Dalton work together to solve the Greek debt crisis, but not everyone at home is happy with the agreement. Meanwhile, Henry mulls over a new job offer, and Stevie reconnects with her childhood friend, the President’s son.

When Elizabeth and her staff fly to Africa to offer development aid to the continent, they are caught by surprise when the Chinese arrive there first, ready to outmaneuver the U.S. with competing offers of aid. Also, when turbulence on their plane ride to Africa leaves Daisy unnerved, she and Susan Thompson go on a welcome tour of Africa, admiring the beauty of the continent. And, the FBI asks Henry to help investigate a Christian cult member who may have helped build the bomb used in the Illinois coffee shop attack.

When an influential rabbi organizing a symbolic Iran/Israel soccer game is killed, Elizabeth and Jay’s peace treaty plans for the two countries are jeopardized. Also, Elizabeth’s name is floated for a Nobel Peace Prize. Jay’s tireless work on the Iran/Israel peace deal strains his marriage. Daisy makes a connection with new work colleague, Kevin Park.

Elizabeth enlists the help of Hollywood star Ashley Whittaker to help sway the president of Kyrgyzstan to end human trafficking in his country, but the added attention could put an American captive at risk. Also, when Henry finds the bomb that’s being held by the doomsday cult, he uncovers information that they could be planning a deadlier attack.

As the government shutdown shows no sign of progress, Secretary of State McCord must negotiate an agreement between the White House and its opposition led by Senator Morejon. Also, Elizabeth is having trouble finding a suitable replacement for the chief of staff position.

Senator Morejon puts phase two of Elizabeth’s U.S./Iran arms deal in jeopardy when he asserts that Iran funneled money from phase one of the deal to fund a recent bombing that killed an American citizen. Also, Henry mulls over the option of becoming the chairman of the new military ethics department at the National War College.

Elizabeth is attending a summit in Montreal to resolve territorial claims of the North Pole when an activist group detonates a bomb and she can’t locate Jason and Piper. Also, things take a turn for the worse when Elizabeth learns that Russia was involved in the bombing, and Henry helps one of his students work through a difficult decision.

When a Texas state trooper is killed by a Mexican cartel smuggler, Elizabeth arranges an extradition deal before going on vacation to celebrate her 25th wedding anniversary in New York City. However, when political issues arise around the case, she is forced to cut their trip short. Also, Elizabeth’s son injures himself while Blake is watching him.