After Elizabeth delivers her first speech to the United Nations General Assembly formally condemning the terrorist group Hizb-al Shahid, she discusses forming a coalition against them with the Russian Foreign Minister. However, the talks create a conflict of interest between Elizabeth and Henry, who is searching for a way to save Dmitri’s ill sister, Talia Petrov, from the Russian government.

When President Dalton gets word that the world’s most wanted terrorist, Jibral Disah, is hiding in Islamabad, he sends the “Murphy Station” – Henry, Jane and Jose – on a dangerous mission to eliminate the threat. Also, Elizabeth and Henry go to couples therapy.

When Elizabeth receives shocking news about an important political operative, she navigates a tricky political situation with President Dalton, who she learns may be considering replacing her as Secretary of State. Also, Stevie and Jareth get engaged.

Elizabeth takes advice from former Secretary of State Madeleine Albright and ignores President Dalton's recommendation on how to negotiate the safe return of a Sate Department employee who was kidnapped in Afghanistan. Meanwhile, Henry is having trouble persuading a student to spy for the U.S. government.

Jay and Kat devise a way to help persecuted foreign LGBTQ citizens escape their country while their U.S. homeland security applications are processed. However, when the country closes its borders, Jay and Kat are forced to change that plan quickly, as it could now threaten their relationship with neighboring allies.

As Elizabeth holds peace talks between the prime ministers of India and Pakistan, a mysterious plane crash tied to both countries causes the three parties to reevaluate the deal. Also, in an attempt to help the NSA locate the terrorist Jibral Disah, Henry approaches a former teacher of one of Disah’s wives for information, and Elizabeth withstands a grueling interview with Jane Pauley.

When the upcoming marriage of two star-crossed lovers from Colombia is in jeopardy, Elizabeth works to reunite the son of the Colombian president and the daughter of the rebel leader, whose union is at the heart of an important peace deal after years of civil war. Also, Henry prepares to send his operative undercover, Jay deals with his tenuous marital situation, and Daisy makes a shocking discovery regarding Kevin.

The President’s plane is declared missing and Elizabeth is thrust into a situation of power she never imagined possible. Also, Henry butts heads with his new Defense Intelligence Agency handler, Jane Fellows, when he’s asked to recruit one of his Russian students for the NSA.

With the support of President Dalton, Elizabeth attempts to get the Senate's support for a history-making effort to lift the Cuban trade embargo. Also, Henry and Alison bond while touring Havana together.

Elizabeth tries to salvage a peace deal with Russia after an unexpected turn of events threatens to dissolve the agreement. Also, Elizabeth gets dragged into dealing with an emergency situation aboard the International Space Station.

After his father’s death, Henry’s family uncovers shocking secrets that open old wounds for them, including his grieving sister Maureen, who blames Henry for not spending enough time at home. Also, Russell keeps important information from Elizabeth’s team at the State department.

After an Italian warship answers a distress call from a ship carrying Libyan refugees, Elizabeth is given 20 minutes to decide whether to question a passenger who claims to know the whereabouts of Jibral Disah, the most-wanted terrorist in the world. Also, Stevie brings her boyfriend Jareth home to meet her parents.

While Elizabeth accompanies Alison on a college campus tour, she is ambushed by protestors about a Chilean mining operation involving the U.S. and Chilean governments. Also, Henry, Jane and Jose Campos attempt to track down Jibral Disah's third wife, Hijriyyah

Elizabeth learns that a member of the inner circle of the terrorist group Boko Haram has fallen ill with a deadly virus and, by leveraging his weakness, she formulates a plan to get them to release a group of schoolgirls they are holding captive. Also, Henry gets new information on the whereabouts of Jibral Disah that leads them closer to pinpointing his location.

The United States debates enacting a “render safe” mission to secure nuclear weapons that belong to the Pakistani government before it collapses, while the Murphy Station pursues the terrorist Jibral Disah.

When warring rebel groups threaten Elizabeth’s Somalian food relief efforts and kidnap an American aide there, she reluctantly considers asking a notorious Russian arms dealer for help. Also, Henry is blindsided when he is taken off the VFF doomsday cult case, and Alison and Stevie await their college acceptances.

Elizabeth seeks creative solutions when the president of Sri Lanka's psychic convinces him to not move forward with a trade agreement with the U.S. Also, Alison grapples with guilt for missing the warning signs after her college roommate attempts suicide, and Henry makes an abrupt career decision.

Elizabeth and the team are caught in an uncertain situation when they are about to award a foreign leader with the Medal of Freedom but learn he may have known that a minority group in his country is being persecuted. Also, President Dalton doubts his ability to return to office after being cleared by his doctor, and a past family grievance is brought to light when Henry’s sister pays a visit.

Elizabeth’s negotiations for a security agreement combatting gang violence in South America becomes complicated when she attempts to free an American recently kidnapped there.

Elizabeth and President Dalton work together to solve the Greek debt crisis, but not everyone at home is happy with the agreement. Meanwhile, Henry mulls over a new job offer, and Stevie reconnects with her childhood friend, the President’s son.

Elizabeth, to her surprise, is met resistance when she travels to Myanmar to sign a Pacific Rim trade agreement, which will modernize the country's power grid and benefit several of its trading partners. Meanwhile, Nadine attempts to mend her relationship with her estranged son.

While Elizabeth oversees a mission to track down the culprits behind a uranium heist in Eastern Europe, she also contends with highly sensitive issues in Saudi Arabia, including the apprehension of two American teenage girls who intended to join a terrorist group, that threatens to dismantle an important arms deal.

When Elizabeth and her staff fly to Africa to offer development aid to the continent, they are caught by surprise when the Chinese arrive there first, ready to outmaneuver the U.S. with competing offers of aid. Also, when turbulence on their plane ride to Africa leaves Daisy unnerved, she and Susan Thompson go on a welcome tour of Africa, admiring the beauty of the continent. And, the FBI asks Henry to help investigate a Christian cult member who may have helped build the bomb used in the Illinois coffee shop attack.

When an influential rabbi organizing a symbolic Iran/Israel soccer game is killed, Elizabeth and Jay’s peace treaty plans for the two countries are jeopardized. Also, Elizabeth’s name is floated for a Nobel Peace Prize. Jay’s tireless work on the Iran/Israel peace deal strains his marriage. Daisy makes a connection with new work colleague, Kevin Park.

Elizabeth enlists the help of Hollywood star Ashley Whittaker to help sway the president of Kyrgyzstan to end human trafficking in his country, but the added attention could put an American captive at risk. Also, when Henry finds the bomb that’s being held by the doomsday cult, he uncovers information that they could be planning a deadlier attack.