Sharon and the team investigate the murder of a young man pushed off the top of a parking structure who was somehow able to afford a high-end apartment without any visible means of support. Meanwhile, Lt. Andy Flynn suffers through the ministrations of an overly cheerful physical therapist.

Jack Raydor (guest star Tom Berenger) is back again, defending a man who is attempting to withdraw a confession in the murder of his wife. A last-second video purporting to provide the defendant with an alibi alerts the Major Crimes team to the possibility of a conspiracy. Rusty interviews Slider, while Flynn is still living with Sharon due to his injury.

The Major Crimes team is called to investigate a follow up attack on a victim of road rage, as a business executive and his wife fall prey to a furious driver in a pickup truck. As Thanksgiving approaches, Flynn suffers a setback on his road to recovery. And Rusty finally gets the interview with Slider that he wanted.

A young woman and her 3-year-old son are shot to death while driving through gang territory in the wrong colored car, and the gun used in the murder is quickly connected to the most troubling series of unsolved homicides in LAPD history. As Captain Sharon Raydor and the rest of her division attempt to solve the mystery, Amy Sykes begins an uneasy alliance with a disgraced former LAPD detective with a novel theory and a corrupt past.

The department is still reeling with the recent departure of Deputy Chief Brenda Lee Johnson, creating a tough transition for the newly appointed head of Major Crimes, Captain Sharon Raydor. But there is little time for adjustment as the department rushes to reach a plea bargain when a string of grocery store robberies turns fatal. After proving to be a valuable source for the case, undercover police detective and military veteran Detective Amy Sykes is transferred to Major Crimes. Meanwhile, Raydor takes a big step to protect teenager Rusty Beck after he runs away from his foster family.

The unit joins forces with the FBI when a homicide case spins around the Israeli mob and an "intuitive life strategist." Elsewhere, Provenza displays his vulnerable side, and Rusty's first school day takes an unexpected turn.

The city's tourist industry is threatened by an English journalist when a pair of British tourists are attacked on their second honeymoon in Venice Beach; Rusty's biological mother tries to make peace with him.

Lts. Andy Flynn and Mike Tao delve into the mysterious overdose of a young Hollywood star and the trail of emotional destruction he left in his wake, while Rusty finally comes to a conclusion about how to handle the pregnancy of his biological mother.

Growing pains within Major Crimes become apparent as the division works to obtain justice in a brutal homicide that turns out to be more complicated than expected. Raydor struggles to gain the respect of her colleagues while also trying to supervise Rusty 24/7. The changes within the department may become more than Provenza can accept.

When a child with gender dysphoria goes missing, the Major Crimes division scrambles to solve the emotional case before it's too late. Torn between several suspects, the squad has to be careful as it tries to connect the evidence to a dangerous bully. Meanwhile, Jack Raydor attempts to make up for years of lousy parenting.

In a case that hits a little too close to home for Rusty, a 19-year-old prostitute is brutally murdered. The squad rushes to reach a deal with the remorseless killer they believe is part of a larger criminal enterprise. Their efforts, however, do not sit well with the judge assigned to the case.

There is a miscarriage of justice when a gang banger is acquitted of murder and released from custody. Sharon’s ex-husband, Jack Raydor represents the suspect in a subsequent murder. Rusty takes a chance when the guy he has a crush on visits the station.

The squad investigates a double homicide related to an ongoing string of home invasions in the Hollywood Hills. Meanwhile, Sanchez attempts to reintegrate himself in the division after his suspension over a questionable use of force, while Captain Raydor makes a fateful choice in the life of her adopted son, Rusty.

The squad investigates the disappearance of a teenage girl who vanished while volunteering at a homeless shelter; Buzz opens the cold case file on the murder of his father and uncle; Andy Flynn considers selling his house.

When Captain Sharon Raydor and the Major Crimes Division investigate the murder of a young woman found in the LA River, their case is not only impeded by a secretive PI working for a tech industry millionaire, but also by Deputy Chief Winnie Davis, who regards Sharon as competition for the promotion to Assistant Chief of the LAPD.

A murder case goes sideways at trial when defense attorney Linda Rothman is able to destroy Det. Amy Sykes' credibility on the stand. Helping Rothman as a defense investigator is Amy's old nemesis, Mark Hickman.

The Major Crimes division faces a new challenge as they work to solve the murder of a dog that was left a 20 million dollar estate by his deceased owner. With the help of wannabe detective Jonathan Baird, aka Dick Tracy, the case takes a new turn as the squad begins to suspect foul play in the death of the dog's owner, a wealthy heiress.

A Hollywood comeback is interrupted when a former child star is found dead on skid row, leaving the director of the actor’s current movie and his manager as prime suspects. Flynn’s daughter comes to visit and the true nature of Sharon and Flynn’s relationship comes to light.

The murder of a Sex Crimes detective leads Major Crimes into the world of pornography; Rusty's biological mother returns with some surprising news.

Sharon's son, Ricky, comes home for a surprise visit while Major Crimes investigates what looks like the "follow home" murder of a retired LAPD fraud detective, who may have been murdered for an arrest she made decades ago.

When an activist to end human trafficking is murdered, the investigation leads to a possible eyewitness, a young prostitute wanting to get out of the business, and the pimp she works for becomes their primary suspect. Meanwhile, child services arrange a meeting between Rusty and his father, against Rusty's wishes.

The unit runs into difficulty when it comes to identifying a suspect after two individuals are attacked with scissors at a high school party; Provenza meets a woman who has an unusually powerful and immediate impact on him.

When a jogger takes a nasty fall down the stairs, Major Crimes finds itself investigating a divorce attorney with a lot of angry clients, and Lt. Tao goes undercover in the world of college-aged hookers. Meanwhile, Buzz connects his partials to a complete print and identifies a suspect.

When Major Crimes discovers a young one-man-geek squad in the middle of his Atwater living room with his throat cut, suspicions swirl around his roommate and some unwitting customers, all of whom he was blackmailing.

As the war between bikes and cars escalates in the streets of L.A., Acting Assistant Chief Fritz Howard deploys Major Crimes to solve a tragic hit-and-run. Lt. Provenza, frustrated by the never-ending contest to succeed Russell Taylor, contemplates retirement.