Joe and Bill are called to an apartment where the building manager has found a young woman bound and dead. The extremely chatty 91 year old manager, who is obsessed with crime novels, is their prime suspect.

Joe tries to stop a burglary at an all night launderette and ends up exchanging fire with the suspect. When SID tries to find the bullet fired at Joe, they come up empty and Joe faces a shooting board with no proof the man ever fired at him.

A new officer has been arrested for robbing a liquor store while on an undercover assignment.

Joe is enrolled in night school and busts a classmate for possession of marijuana. The professor threatens to give Joe an F for the bust. He puts removing Joe up for a vote by the class. An unexpected classmate comes to Joe's aid.

Joe and Bill investigate a series of victims. An elderly man has been stabbed to death in his hotel room. An elderly is assaulted and her purse stolen. A store is robbed and the owner is stabbed. Rights are given to the criminals, but there are no rights for the victims.

Joe and Bill are assigned to the Medical Services Division. Two policemen have been shot. Joe and Bill must notify the wives.

Sergeant Joe Friday and his partner Bill Gannon encounter a freaked-out young LSD user calling himself "Blue Boy"; before long, Blue Boy is "turning on" schoolchildren with the mysterious new drug.

A series of daring daylight house burglaries are taking place. Friday and Gannon go undercover in a laundry truck to discover the perp.

Burglaries are happening and the thieves are leaving a red cloth at each crime scene. Joe and Bill respond to another break in at a chemical company and a safe company. Joe and Bill stake out the chemical company and catch an unexpected pair of thieves.

There is a multiple homicide at a rooming house. When Joe and Bill arrive, they find two dead in the lobby near a broken TV set and the manager has been shot and is near death. The manager mumbles the words "oft one" to Joe as he is taken away to the hospital. Bill and Joe start searching for clues and what the manager's words mean.

A statue of the child Jesus was stolen from a church. Joe and Bill have to get it back by Christmas. They have less than 48 hours.

When a nine-month old child is beaten, Friday and Gannon investigate the parents, who are more concerned about their failing relationship than their baby son.

A 15-year-old car thief is given a tour of the jail in an attempt to impress him of the consequences for choosing crime. Unfortunately, it doesn't work - the young man later kills someone with a shotgun.

The Captain assigns Joe and Bill to find the location of a high stakes poke operation that has been preying on visitors. Bill and Joe pose as farmers and check into a hotel where an agricultural convention is occurring.

Joe and Bill are working Juvenile Narcotics Division and find a 12 year old under the influence of narcotics. They go to the boy’s school and conduct a class for teachers on how to identify narcotics. They discover that a ninth grader is selling the narcotics in school and find that his father is the source of the drugs.

A police officer is shot while making a routine check on a pair of paroled convicts that are parked near a liquor store.

A Japanese widow is senselessly murdered, leaving her small daughter an orphan. Friday has a hard time controlling his emotions while seeking the killer.

An elderly businessman, concerned about the welfare of his grandchild, informs Friday and Gannon that his daughter and son-in-law are using marijuana regularly. The young couple make no apologies for their lifestyle, which inevitably leads to disaster.

Friday and Gannon are on the case to find ... a purse-snatching dog? Making things more difficult, victims give different descriptions of the four-legged thief.

Two small girls, ages three and five, are missing. Their mother is certain that her ex-husband, an alcoholic, has kidnapped them. However, he is now in recovery and has no knowledge of the girls' whereabouts. The search seems hopeless until Friday and Gannon, acting on information from a former neighbor, follow a hunch.

The Captain ask Joe and Bill to investigate having dogs trained to sniff out narcotics. They contact a dog trainer to train dogs for the job. Joe and Bill do a demonstration for Judges to prove the effectiveness of using a dog to detect marijuana.

Joe and Bill investigate someone who has fraudulently obtained disability checks. This person has been renting apartments and only using them as a mail drop. Joe and Bill meet with a group of apartment owners to ask for their help.

A neo-Nazi psycho has planted a bomb somewhere in L.A. Friday and Gannon have to find it.

Gannon goes undercover as a buyer in order to trap fur theives.

Friday and Gannon use newspapers, radio and TV to seek the public's help in identifying a hit and run driver.