Mannix is hired to find out any dirt on Govenor-elect Adam Pierson, and that's when the trouble starts: with his syndicate connections, people are dying fast.

Mannix is set up for the murder of an old girlfriend's husband.

A scientist goes missing with a new formula.

Mannix takes the case of a death row inmate.

A threatened suicide.

An incommunicado coed and a murdered basketball player.

Mannix is hired to vet a prospective bridegroom.

Investigating an insurance claim, Mannix finds himself intensely scrutinized.

A missing boy and a cover-up.

Blackmail in the film industry.

A libel suit against a newspaper at the state capital involves politics and the mob.

An undercover cop's murder exposes a vice operation.

Undercover at a health farm for boozehounds.

Mannix checks out an actress with an enemy.

A psychopath's next victim might be his wife.

The strong friendship between Lew Wickersham and Mannix melts into a violent and deathly feud. The bitter battle begins when Mannix launches an investigation into the theft of a highly secret formula for the development of a laser ray. Stolen plans and sabotage involve Intertect and their agents.

The two paths of the case meet at the water's edge.

Mannix quits rather than chase a necklace and a mobster, and stumbles into a case of murder and fraud.

A missing million leads Mannix out of Intertect as bait for a drug ring.

A faith healer gets blackmailed.

Old labor woes come to light after an attempted murder.

An unsolved murder and an author with enemies.

A fake Renoir is suspected, and the model is in danger.

A premonition is the only clue.

A quiet town is ruffled by Mannix in his search for a missing youth.