Kaz and Oliver are trapped in the ER by an evil Skylar and the Annihilator and the two villains plan on taking over the hospital and eventually, the world.

Kaz needs to get a flash drive that Oliver got out of the principal before it explodes.

A man from the future visits the boys and reveals himself as Kaz twenty-five years from now. Future Kaz warns the boys of an evil villain wreaking havoc on the future.

As Kaz stands by the Bionic Academy's dying Chase Davenport in the superhero emergency room, Oliver and others seek to stop Incapacitator before he incapacitates the planet.

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Oliver and Kaz attempt to visit the Annihilator's lair to take his collection of superpowers and restore them to the superheroes.

Oliver and Kaz travel to Skylar's home planet, Caldera, to search for the Annihilator's former mentor, Hapax the Elder.

Jordan theorizes that superheroes are real; Stefanie calls Skylar out for having a fake identity.

Gulliver and Chaz stumble into Mighty Med and Horace hires them, threatening Oliver and Kaz; Skylar makes a suggestion box to boost staff morale.

Oliver experiences a weirdly vivid dream that inspires a story for a Tecton comic; Alan assist Horace in wedding planning.

Kaz and Oliver suspect that there could be a hospital mole that is working with the Annihilator.

Kaz and Oliver find themselves ambushed by the Annihilator and Skylar Storm on Caldera. With the help of Hapax the Elder, the boys must find a way to take down the supervillains and save the world.

Oliver, Skylar, Alan and Gus leave Mighty Med to work on a school project together, and Kaz is left alone at Mighty Med while a rare and dangerous alien bug is on the loose.

In an attempt to recruit new superheroes, Kaz holds superhero tryouts. Meanwhile, Oliver takes Skylar to a dance tournament to try to cheer her up when she's not allowed to compete in the superhero tryouts.

The Key Keeper announces his retirement, and Skylar and Kaz both express interest in becoming his replacement. Meanwhile, Oliver meets his mother's new boyfriend for the first time.

Oliver is in charge of rehabilitating Wallace and Clyde since he believes they still have good left in them. Meanwhile, Kaz tries to give himself super powers with Skylar's help.

Oliver must care for a sack of highly valuable eggs when a pregnant female superhero is wheeled into the ER. Kaz helps Oliver hide his "pregnant" state at school.

Kaz and Skylar search for the all-powerful Arcturion; Oliver recruits an unlikely candidate to protect him from Mr. Terror.

Oliver grapples with an internal conflict as he walks his mother down the aisle. Meanwhile, Kaz and Skylar struggle to protect the Arcturion from all the villains it beckons.

When superhero Spark, a tough-as-nails teenage girl, meets Kaz at Mighty Med, they have an immediate connection. However, it fizzles quickly when she becomes overly possessive. Meanwhile, Horace puts Skylar in charge of security to keep villains out of Mighty Med.

Kaz and Oliver know that Skylar is evil, but Skylar doesn't know they suspect anything. They need to keep it that way or she may turn on them as well. They brace themselves until Skylar asks Oliver to the school dance that night.

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