Declan Dunn, an anthropology professor who also investigates miraculous phenomena that happen to people everyday, meets Peggy Fowler, a psychiatrist at a local hospital and a skeptic. Together they try to explain how an 11-year-old boy was miraculously saved from drowning in a frozen lake.

A man promises his wife on his deathbed that he will contact her exactly one year after his death to prove that there is life after death. As the anniversary draws near, Declan and Peggy are drawn to see for themselves if a miracle happens, as opposed to investigating one after the fact. Peggy, a widow herself, can relate to this woman's pain and loss, but in the end she discovers some faith of her own.

Peggy and Declan discover a town whose citizens have overwhelming good fortune. Upon further investigation, they uncover the town's secret, a woman who supposedly has the gift to give people good luck just by touching them.

On a white-water rafting trip, Declan is thrown from a raft and ends up miles downstream, badly hurt with a broken leg. Luck is on his side, however, as a kindly old man named Dr. Nader discovers him and takes him to Camp Sanopi, a secluded retreat deep in the woods. But Declan soon discovers that this blissful camp is not what it seems to be and that although all are welcome, none can leave.

Declan travels to the small town of East Gilmore to investigate a mysterious legend of protective spirits. There, he discovers more than just an eerie tale of children's ghosts pushing stalled cars off railway tracks, but a town full of pain, unable to recover from a horrible tragedy.

When two students in Declan's anthropology class exhibit uncanny similarities, Declan becomes curious when both adopted young men turn out to share the same birth date, the same mannerisms, tastes, and test answers, but a blood test determines that they aren't related. When one of them becomes ill, the mystery of what brought them together intensifies. Meanwhile, Declan and Peggy discover they share a coincidence as well.

Peggy and Declan find themselves at odds when Declan interferes with one of her patients - a schizophrenic who claims to be hearing a voice. Peggy wants to put her on medication, but Declan suspects there may be more to this voice that's trying to communicate with her.

Declan's overwhelmed assistant Miranda starts to act strangely, and along with three other people, she finds herself drawn to a bridge in New Zealand. Though none of them know why they're there, all of them feel the urge to jump off this bridge. As the mystery unfolds, they discover that the bond they have between them is deeper than they ever imagined.

Peggy is assigned to the case of an attempted suicide and piques Declan's interest when the girl claims she is haunted by demons. As Peggy struggles to help the tormented girl, Declan uncovers a terrible secret lurking behind the patient's disturbances.

A window washer falls from the side of a very tall building and crashes through the top of a parked convertible landing in the passenger's seat next to a very frightened driver. He is dazed but un-injured. Declan, Peggy and Miranda must investigate how this could happen and find a very interesting coincidence.

A student see's a dead man when he look's into a mirror. Each time he see's the man it's from a deferent time in the man's life. This leads Declan to the cause of the man's death.

When Declan investigates an old woman with the miraculous gift of being able to predict future events by means of a mysterious handwriting, he discovers the woman to be amazingly accurate. But when she looks at him and writes the words ""Your sister is dying,"" it sends Declan on an emotional journey of reconnection with a sister he's alienated. As Declan struggles urgently to uncover the truth of the woman's prediction, he learns that before he can help to heal his sister, he must first heal himself.

Peggy struggles when she begins seeing the ghost of a patient who recently committed suicide, jeopardizing her career in the process. Meanwhile, Declan also finds his employment at risk when his pursuit of miraculous phenomena interferes with his classroom responsibilities.

As a funeral takes place in an inner city church from another gang related shooting, something unbelievable occurs – an image on a stained-glass window begins weeping tears of blood. In the midst of Declan's investigation, another miracle occurs within the community – the people, taking the icon's tears as a message to stop the violence, begin banding together, helping the gangs to resolve their differences. Declan is left with the moral dilemma of disproving this ‘miracle' to a community in desperate need of an answered prayer.

Declan uncovers a cloth in a 17th century tomb that they discover is the veil of Veronica, a religious relic with the power to heal. It is used to heal Cancer patients but soon starts to disintegrate. While looking for a method of preservation, the veil is sealed until Miranda is struck with a deadly virus and Declan is forced to make the decision whether to save his friend or save the veil for the good of mankind.

When a cop's partner is shot to death while investigating a break-in, the cop feels responsible. That night, the distraught cop says a silent prayer--if only he could have this day back. The cop wakes the next morning to discover he's gotten his wish--he's living yesterday all over again. But unfortunately, he's the only one who knows it. Through this investigation Declan and Peggy learn a lesson about altering the course of destiny.

Declan hears about a man who had a premonition of a recent plane crash. When Declan investigates whether or not the premonition was real or just a fabrication he makes a startling discovery, which could alter the lives of two families forever.

While Peggy treats a patient who suffers a near-death experience during surgery, Declan investigates a foreign cardiologist who's wooing her -- and discovers that the so-called doctor might be more of a killer than a healer. Fearing Peggy is being courted by this con man, Declan delves into his background and unearths the mysterious disappearance of the suitor's last romantic conquest.

A man who lost his hearing twenty years ago when he was first struck by lightning, is again struck by lightning. Now he seems to not only have his hearing back, but also amazingly has the power to foretell future events using sound.

A mother comes to wake her daughter for school but finds her missing; across town, the daughter is found asleep in a park, still in her pajamas, and no one has any clue as to how she got there. The episode leads Peggy and Declan to help the parents re-discover just what is important in their lives -- and show them that it's not too late to put things back the way they once were.

Declan's mentor, Rudy, becomes Declan's next miracle mystery, when the old anthropologist begins having bizarre visions, including tacky alien spaceships, circus clowns and even the Big Bad Wolf. Declan brings Rudy to see Peggy, who thinks these visions are the result of stress, but when she has him undergo a physical check-up, a brain tumor is discovered. The tumor is pressing on the part of the brain that houses memories, thus triggering these strange visions -- memories from Rudy's childhood. But one of the memories is of a young girl -- the childhood sweetheart Rudy let go. With Declan's help, Rudy is able to make contact with the woman, who just recently divorced... right about the same time Rudy started having these visions.

After dying in the ER, an man suffering from amnesia comes back to life with a new, more positive, demeanor. The resulting chain of events proves that what goes around really does come around.

A fireman engulfed in flames staggers out of a burning house and miraculously escapes without a single burn. When several other seemingly connected unbelievable coincidences occur, Declan investigates and witnesses what could be a miracle.

Dwayne Banbury, one of Declan's students, is shot in a variety store hold up, but miraculously, the bullet seems to have passed right through him, leaving him unharmed. Dwayne's friend Jonathan comes to believe that Dwayne is a real life superhero who can finally help him take revenge on the popular students who have harassed him his whole life. In the end, the true miracle is a lesson in tolerance.

Declan, Peggy and Miranda trek through the Indian wilderness to find a ""Holy Man"" who supposedly possesses remarkable healing power. But an incompetent guide and a series of strange accidents put their lives in jeopardy.