At an off-site army base, Joel and Zach get in a precarious situation; a hypothermia victim fights for the life; Alex, Maggie and Rian write their Surgical Boards.

Alex is diagnosed with an irregular heartbeat but must care for the Great Randall; Charlie deals with the aftermath of the fight; one of the staff is attacked.

Casualties of a bomb at a local charity run arrive at Hope Zion Hospital.

During an ice storm on Christmas Eve, Alex and Dawn fight to keep a woman alive long enough for her family to say goodbye.

Alex discovers that she unknowingly helped the bomber at the expense of a friend.

Alex and Shahir struggle to save Charlie's life.

Alex tries to distract herself from her grief. Charlie and Shahir try to track down Alex's brother. Alex treats a young girl with kidney failure. Maggie and Sydney treat a young woman with an STI.

The doctors at Hope Zion Hospital are forced to deal with people from their past as Alex, Charlie and Joel take on the daunting task of operating on a malpractice lawyer known for suing every doctor in his path. Meanwhile, Zach is tested when the last person he wants to treat comes into his E.R. and a Season 1 patient returns with some difficult insight for Charlie and Alex.

When Alex’s brother Luke is admitted to Hope Zion Hospital in critical condition, Joel and Charlie must work together to keep him alive while keeping his admittance a secret from Alex. Meanwhile, Alex figures out a way to remove a tumour from a patient pregnant with twins, while Maggie is thrown off her game by the patient’s gorgeous OB/GYN.

Celebrated neurosurgeon Thor MacLeod gives Alex an offer; Charlie deals with a fatigued spirit; Joel ends up in a fight at the clinic.

A young motocross rider is diagnosed with Leukemia, forcing Dr. Alex Reid to navigate family secrets in order to put her young patient on the road to recovery.

Faced with a chef who refuses treatment, Alex is forced to confront how she feels about Dana's methods.

Alex and Cassie try to free a young woman from her abusive partner; a patient's pacemaker malfunctions.

The doctors rally together to try to save an unknown man who was struck by a subway train. Randal delivers a warning about Charlie's gift. Dr. Sydney Katz returns to town.

When Alex and Joel end up stranded in the middle of nowhere with a severely injured couple, they’re forced to use only what’s around them to stabilize the pair until paramedics arrive. Meanwhile, back at Hope Zion Hospital, Charlie must try to save the wounded leg of his former college roommate as Gavin attempts to help Shahir improve his bedside manner.

Alex performs surgery on one of the hospital's own doctors; a routine checkup turns deadly; a medical conspiracy extends far beyond Hope Zion.

Alex is surprised twice in one night – first when she realizes she's been tricked into a blind double date, and again when she has to rush her mystery man to the ER.

Alex witnesses an accident involving a John Doe; Charlie and Gavin have a spiritual therapy session.

Alex and Jeremy try to solve a child's mystery illness; Charlie treats an actor; Maggie reaps the rewards of compassionate medicine.

Kristine suffers a stroke, which impacts her memory; Alex and Charlie team up to bring her peace.

Alex and Maggie work together to deliver a baby. Charlie treats a magician.

Alex and Charlie are caught in the middle of a shooting on their way to their first shift back at Hope Zion. In the midst of the commotion, Alex treats a bullied teenager and deals with her own emotions about everything that’s happened in the past year. Meanwhile, Charlie is caught off guard when he realizes that he’s still able to see the spirits of deceased patients. As well, new Chief of Surgery Joel works alongside Charlie’s ex-wife Dawn to perform an intense surgery.

Alex is trying to get her life back to normal with Charlie and at Hope Zion Hosital – but with Charlie’s head in the clouds and the pressure to find her medical niche – she’s struggling. Inspiration comes in the form of an immigrant doctor who needs Alex to save his wife’s life, and in return, helps her find her calling.

A couple is attacked by a bear, but Alex and Charlie think there's more to the story; a Buddhist tries to teach Joel a lesson.

Alex races to find an organ replacement; Joel helps a couple; Charlie is pushed to his breaking point.