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The Best Episodes of Mystery ER

Every episode of Mystery ER ranked from best to worst. Let's dive into the Best Episodes of Mystery ER!

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Mystery ER is a medical reality program, created by Mike Mathis for the Discovery Health Channel. The show features reenactments of real-life medical mysteries, told through narration and interviews.

Airs on
Discovery Health Channel
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Seasons2

All12

Episode Rankings

  1. #1 Fan Favorite
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    Mystery ER Season 2 Episode 1 - Scared Stiff/Deadly Grind
    5.8/10(6 votes)

    #1 - Scared Stiff/Deadly Grind

    S2:E1

    SCARED STIFF When a single mother wakes up to find she can no longer walk, her doctors go looking for the elusive disease they suspect is afflicting her central nervous system. Despite aggressive treatment, the nightmare returns to take back the gains she has made, until one specialist can track down the rare source of her paralysis. DEADLY GRIND The small town of New Sweden, Maine, is stunned by the sudden illness of more than a dozen parishioners who all show up at the local ER after church. At first doctors believe an epidemic is sweeping the town, but when one patient dies of the mysterious disease, the police begin an investigation that ultimately uncovers a shocking crime.

    Director:Unknown
    Writer:Unknown

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  2. Mystery ER Season 1 Episode 1 - Burning Love/House of Deception
    0.0/10(0 votes)

    #2 - Burning Love/House of Deception

    S1:E1

    Doctors are puzzled as they examine little Ricky, a frequent patient of the E.R. with persistent vomiting and an odd rash around his mouth and chest. There's no explanation for why the young child wheezes, but his every breath is a painful struggle.

    Director:Unknown
    Writer:Unknown

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  3. Mystery ER Season 1 Episode 2 - Hard to Swallow/Culture Shock
    0.0/10(0 votes)

    #3 - Hard to Swallow/Culture Shock

    S1:E2

    When Aaron's panic-stricken parents bring their son into the E.R. with seizures, doctors discover a strange mass inside the boy's brain. Fearful it's cancer, they prepare Aaron for a biopsy until a sharp-eyed radiologist identifies it as a pork tapeworm.

    Director:Unknown
    Writer:Unknown

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  4. Mystery ER Season 1 Episode 3 - Seeping Through the Cracks/Purple Haze
    0.0/10(0 votes)

    #4 - Seeping Through the Cracks/Purple Haze

    S1:E3

    Arunas has lived his life in good health, but after turning 50 he suddenly experiences recurrent bouts of vomiting, heart palpitations, weakness, and malaise. After rigorous testing, doctors suspect he is mentally ill, but one last test says otherwise.

    Director:Unknown
    Writer:Unknown

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  5. Mystery ER Season 1 Episode 4 - Bittersweet/Ring of Fire
    0.0/10(0 votes)

    #5 - Bittersweet/Ring of Fire

    S1:E4

    The pain in Alice's legs and back is unbearable. Doctors find nothing and suspect she's neurotic. When her son and neighbors begin to experience similar symptoms, the doctors are baffled. But the cause is not an epidemic, it's a vindictive boyfriend.

    Director:Unknown
    Writer:Unknown

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  6. Mystery ER Season 2 Episode 2 - Truth Be Told/Climbing for Life
    0.0/10(0 votes)

    #6 - Truth Be Told/Climbing for Life

    S2:E2

    "TRUTH BE TOLD" In 1978, during the height of the Cold War, a military wife suffers a sudden paralysis in her leg that defies explanation. As she slowly slips into a near-catatonic state, a team of military medical specialists investigates the elusive cause that may have something to do with her husband's top-secret work. "CLIMBING FOR LIFE" When a 16-year-old champion rock climber falls victim to a mysterious illness, his surgeon father takes him to the ER, where he quickly slips into a coma and must be put on a ventilator. As his lungs fill with fluid, his doctors must act fast to stem the virulent disease that is attacking his system.

    Director:Unknown
    Writer:Unknown

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    7. Trending NowTRENDING NOW

    The 20 WORST Episodes of Mystery ER

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  7. Mystery ER Season 2 Episode 3 - Dead in Ten/Speed Bump
    0.0/10(0 votes)

    #7 - Dead in Ten/Speed Bump

    S2:E3

    "DEAD IN TEN" When a young woman goes to the ER with severe abdominal pains, the doctors find a rare and virulent type of cancer that gives her ten years to live. There's something more to this mystery though and the woman must find what it is before time runs out. "SPEED BUMP" When a vibrant, teenage athlete suddenly turns into a listless zombie, his nurse mother goes looking for answers. Her medical training leads her to record in a diary everything that her son does, and she soon finds a pattern in his behavior that leads his doctors to an astonishing diagnosis.

    Director:Unknown
    Writer:Unknown

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  8. Mystery ER Season 2 Episode 4 - Desperate Measures/A Stinging Pain
    0.0/10(0 votes)

    #8 - Desperate Measures/A Stinging Pain

    S2:E4

    "DESPERATE MEASURES" (a.k.a. "HOME INVASION") After starting a new life in a new apartment, the mother of a little girl notices her child is suffering from a burning rash. At first, doctors attribute it to the eczema she was born with, but it soon turns into a relentless disease that soon threatens her life. The surprising cause of her illness is eventually found to be a simple case of carelessness. "A STINGING PAIN" (a.k.a "DEADLY DENTAL") After a routine visit to the dentist, a man in Arizona comes into the ER racked in unexplained pain. The doctors find an opaque mass in his back. The man's condition deteriorates rapidly, and the doctors must figure out what the mass is before it's too late.

    Director:Unknown
    Writer:Unknown

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  9. Mystery ER Season 2 Episode 5 - Eating Away/A Model's Malady
    0.0/10(0 votes)

    #9 - Eating Away/A Model's Malady

    S2:E5

    "EATING AWAY" An athletic swimmer gets attacks of near-paralytic exhaustion, after which his urine becomes strangely dark. Over the years his symptoms persist until the day he goes into the ER with symptoms of a cardiac arrest. One doctor feels it isn't a heart attack though...instead the illness is something far worse. "A MODEL'S MALADY" A beautiful young woman wakes up with a blinding headache that turns into a host of unexplained symptoms. These symptoms will eventually take her to the top of the modeling industry, but the woman knows that if she doesn't find the underlying malady this illness will soon kill her.

    Director:Unknown
    Writer:Unknown

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  10. Mystery ER Season 2 Episode 6 - Rash Decision/Inflamed
    0.0/10(0 votes)

    #10 - Rash Decision/Inflamed

    S2:E6

    "RASH DECISION" A.K.A."IRRATIONAL SYNDROME" In 2006 an otherwise healthy college student comes down with a purple rash that literally spreads before his eyes. After a series of ER visits, the doctor narrows it down to one of eight possible diseases. As the college student's health deteriorates the doctor must find the cause of the rash before time runs out. "INFLAMED" An organic health food enthusiast experiences a mysterious rash that leaves her unable to think clearly. When she becomes violently ill, a doctor recommends a radical procedure that could save her life, but would also leave her permanently incapacitated.

    Director:Unknown
    Writer:Unknown

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  11. Mystery ER Season 2 Episode 7 - Painful Truth/Bugging Out
    0.0/10(0 votes)

    #11 - Painful Truth/Bugging Out

    S2:E7

    "PAINFUL TRUTH" A small child loses consciousness and becomes red after exposure to sunlight. In the ER the doctor makes a startling discovery: the child is unable to sweat. Over the years the family realizes that this is but one symptom of a mysterious disorder that if left untreated, could put the child's life in jeopardy. "BUGGING OUT" One day in Southern California a normally healthy man suddenly has trouble walking and spontaneously starts vomiting. Soon the man starts acting in bizarre ways. The doctors realize that this might not be a simple infection...it might be the beginning of an epidemic.

    Director:Unknown
    Writer:Unknown

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  12. Mystery ER Season 2 Episode 8 - Nothing to Sneeze At/String Theory
    0.0/10(0 votes)

    #12 - Nothing to Sneeze At/String Theory

    S2:E8

    "NOTHING TO SNEEZE AT" One morning a strongly built young man blows his nose, and his life is changed forever. He gets violently ill and passes out but the doctors can't figure out what he has. A series of progressively worsening attacks sends him on a downward spiral, and he must find a diagnosis before one more sneeze kills him. "STRING THEORY" A woman feels a profound fatigue and sleeps up to 18 hours a day. Soon she feels as if invisible rats are crawling over her. These "invisible rats" seem to leave strange sores. When the woman puts her sores under a microscope the mystery deepens in ways she had never thought possible.

    Director:Unknown
    Writer:Unknown

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  13. Mystery ER Season 2 Episode 9 - Harley Rides Again/In a Fog
    0.0/10(0 votes)

    #13 - Harley Rides Again/In a Fog

    S2:E9

    "HARLEY RIDES AGAIN" A seemingly healthy Pastor experiences deep pains in his chest. After being treated for a possible cardiac arrest, his symptoms persist over the years until he feels as if he is having a heart attack every day. One friend believes the pastor has a common, treatable illness...one that could kill him if not diagnosed quickly. "IN A FOG" In 2000, a college student becomes disoriented and feels as if she has been drugged. But over the years her feeling of disorientation doesn't go away...and soon she begins developing bizarre symptoms, including hypersensitive hearing and spontaneous dyslexia.

    Director:Unknown
    Writer:Unknown

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  14. Mystery ER Season 2 Episode 10 - Ironic Discovery/Native Tongue
    0.0/10(0 votes)

    #14 - Ironic Discovery/Native Tongue

    S2:E10

    "IRONIC DISCOVERY" A man's health deteriorates as he begins to experience unexplained symptoms. His wristwatches spontaneously break and he starts setting off metal detectors. The man realizes the severity of his bizarre sickness when his son comes down with the same illness. "NATIVE TONGUE" Decades after a serious car accident, a woman spontaneously loses the ability to speak. When her speech returns, she speaks with a foreign accent that won't go away. One doctor thinks he knows why.

    Director:Unknown
    Writer:Unknown

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Best Episodes Summary

"Scared Stiff/Deadly Grind" is the best rated episode of "Mystery ER". It scored 5.8/10 based on 6 votes. Directed by Unknown and written by Unknown, it aired on 7/14/2008. This episode scored 5.8 points higher than the second highest rated, "Burning Love/House of Deception".