Following the kidnapping of Sam's wife, Michelle Hanna, Sam goes rogue from the NCIS team and attempts to stop his arch nemesis Tahir Khaled from ever targeting his family again.

Gravely injured and unable to communicate with the team in the U.S., Callen, Sam and Kensi, with an unconscious Deeks in tow, search for a safe way home as a cartel boss places a “dead or alive” bounty on their heads. Also, Mosely and retired Navy Admiral Hollace Kilbride beseech their contacts in Mexico and D.C. for assistance with their missing colleagues

Akhos Laos , a former black ops agent originally recruited and trained by Hetty Lange, returns to seek revenge on Hetty for the life she introduced him to, on the 250th episode

Anna Kolcheck returns to warn Callen that he is in danger and he must now work with an archenemy to stop an underground trafficking ring.

When Callen goes to the National Counterterrorism Center on the pretext of interrogating a Russian asset from the crashed plane case he investigated months earlier, the tables are turned and he is detained, accused of being a Russian agent.

The NCIS team hunts for a heist crew that robs a Los Angeles casino with military-grade power. Also, Kensi and Deeks hear exciting news regarding the adoption and Callen takes a big step in his relationship with Anna.

The NCIS: LA team finds themselves in danger while investigating a kidnapping case of a man claiming to be Callen’s father.

Some of the team have to assume undercover identities in Moscow so that they can locate their suspects.

Callen and the team try to save a child in imminent danger who has been brainwashed by a terrorist cell. Also, Deeks and Kensi discuss having children.

As the team races to save Kensi from Ferris/Sullivan, they find themselves questioning who they can trust when old faces resurface.

The team must find assailants who illegally crossed the border and attacked California Highway Patrol officers; Homeland Security sends Nell's older and bossy sister to assist with the case.

The NCIS team partners with the FBI to locate a terrorist cell in Los Angeles believed to be preparing for an imminent attack.

As the team continues to search for a terrorist cell in Los Angeles, Callen and Sam remain trapped in a movie theater after multiple bombs have detonated and every remaining exit is wired with explosives.

When NCIS investigates the murder of a man about to reveal the source of a massive counterfeiting operation, an old acquaintance becomes their prime suspect and reveals the true reason for her return. Also, Deeks struggles during training to become an official NCIS agent

While NCIS must track down an organized crime leader who is trying to buy stolen defense technology, Callen goes to Anna to ask the ultimate question. Also, Deeks is kicked out of NCIS training only to find that Hetty has a life-changing surprise for him.

Callen's ex-partner (Marisol Nichols) takes a Navy recruitment center hostage.

The team searches for new evidence to prove Kensi Blye’s innocence after she is taken into custody as the lead suspect in a murder investigation involving her deceased father’s sniper unit.

Callen and Sam fly to Idaho and join forces with NCIS: Red, a mobile team of agents who live together and investigate crimes in various locations, when a murder weapon found there matches one used in a national security case in Los Angeles.

While the LA team chases leads digitally and locally, the NCIS: Red team travels in their mobile trucks, nicknamed "Laverne and Shirley", in a race to track down a cunning terrorist before he disappears.

After learning that Special Agent Kensi Blye disappeared and the Taliban may be he holding her captive, Hetty sends the NCIS: LA team to Afghanistan on a rescue mission.

Callen and Sam find themselves trapped inside an armed submarine that terrorists are intending to use to hit an aircraft carrier in San Diego. Hetty goes against orders and forgoes her trip to Washington, as the team attempt to locate and save Callen and Sam and stop the terrorist attack.

The team investigate an arms dealer but are interrupted as the suspect's building is overrun by terrorists.

Callen embarks on a secret project, leaving Sam and the entire team in the dark. After Hetty demands his operation be shut down, the team is tasked with locating Callen before he finds himself in over his head.

The team travels to Syria to apprehend a High Value Target where one team member is severely injured when the mission goes awry.

After an engineer who was developing a new guided missile destroyer is murdered, Callen and Sam go undercover to track his co-worker aboard a plane to Tokyo to sell the classified intel. Also, Deeks plans a surprise get-together for Kensi and her out-of-town friends.