As NCIS investigates a suspicious death and the missing key piece of evidence is a top secret, high tech battery, Pride and the team realize there could be deadly consequences if it falls into the wrong hands.

As New Orleans grapples with the effects of COVID-19, Pride sends Tammy and Carter to investigate a suspicious death aboard a humanitarian ship offshore, where they learn that some crew members are infected with the deadly disease. Meanwhile, Wade is overwhelmed by the high volume in the morgue due to COVID-19.

When an NOPD officer is murdered, Pride and the NCIS team take on a group of dirty cops when they discover that the victim was also a key witness in multiple excessive force cases. Also, Tammy faces the reality of being in a new relationship.

As the NCIS team continue to investigate the murder of an officer who was about to whistle blow on police misconduct within NOPD, Pride must get creative in order to finally get rid of the dirty cops. Also, the Mayor asks Pride to join her new task force to address systemic issues plaguing their city and, as Covid continues to overwhelm the system, Wade finally addresses the toll it's taken on her.

As Tammy and Carter continue to investigate the suspicious death aboard a COVID-infected humanitarian ship offshore, Pride and the team discover that the PPE they were sent to distribute may hold the key to finding the killer.

When a Navy Commander’s car is stolen with his baby inside, the NCIS team must determine if this was a random carjacking or a targeted abduction.

Racial tensions rise in New Orleans when a white NOPD officer shoots a black Navy officer he believed was armed in the middle of a busy street party.

The NCIS team investigates the murder of a petty officer who was in town to help a refugee family being recruited by terrorists. Also, Wade works on the special election campaign for Mayor Zahra Taylor that takes place during Mardi Gras.

When Pride is unable to sleep due to continuing nightmares about the mysterious man in the red suit, he undergoes a specialized treatment to help him figure out the man’s identity. Also, an arrogant new officer, Special Agent Quentin Carter, joins the team.

The team investigates the deadly bar bombing and impending criminal turf war involving Sasha Broussard. Also, while Pride must come to terms with having Connor in his life, Carter and Hannah work to define their new relationship.

The team uncovers a sinister plot by a private detention center contracted by the government to house undocumented immigrants; Lasalle and Sebastian travel to Alabama to search for Lasalle's missing brother.

When a Navy sailor is found dead, the team tracks the suspicious movements of people in his life prior to his death. Also, Hannah comes to terms with her daughter's relationship with her ex's new girlfriend, Veronica.

When a torpedo hits a fishing trawler at sea, the entire Gulf Coast is in jeopardy as Pride and NCIS race to find the submarine before it can strike again.

While Pride and Rita plan their wedding, the FBI arrests Connor in connection to the bar's firebombing as a means of getting to his mother, Sasha Broussard, and Rita may be the only person who can save them.

A case soon becomes personal for Pride after the body of a Petty Officer is identified as a former gang member he once attempted to help. Brody attempts to find the perfect place to call home in New Orleans.

An armored transport bus with Naval brig detainees on board crashes and four prisoners manage to escape.

The team investigate the murder of a tech liaison, who had been assigned to a private developer.

Pride’s longtime friend, state and military attorney Rita Devereaux, asks NCIS to investigate the disappearance of a JAG lawyer who specializes in classified cases and volunteers at a private military academy.

When Elvis Bertrand's "daughter" is linked to an NCIS murder case, he asks Pride to prove her innocence.

The team investigates the murder of a JAG captain who was discovered at home by his daughter, the only heir to his large estate. Also, Sebastian is intimidated when he is put in charge of a team on his first day of Regional Enforcement Action Capabilities Team (REACT) training.

When a Navy therapist with a high level of security clearance is murdered, Pride and the team discover that she was working around the system to get justice for victims of sexual assault. Meanwhile, Carter's mother confronts him when he refuses to talk to the FBI for a background check on her behalf, and Sebastian starts to form a bond with a key witness who was hit hard by the COVID-19 pandemic.

After a Molotov cocktail is hurled into Pride's bar, evidence leads him directing to his old nemesis, Sasha Brousard, who has been keeping a secret that will affect his life forever. Also, Tammy uses her profiling skills on Hannah and Carter with shocking accuracy.

A Navy lieutenant on shore leave dies of the bubonic plague, sending the New Orleans team into a tailspin to locate all other sailers on liberty to control an outbreak and find the source. Special Agent Tony DiNozzo gives a helping hand.

It's revealed that a chief warrant officers' wife has been abducted, when his death is investigated. Fornell assists with the case.

New Orleans is decorated for Halloween as the team investigate the murder of a Naval Staff Judge Advocate discovered in a cemetery dressed in a Victorian costume with puncture wounds on her neck.