Paul F. Tompkins discusses the Ebola Virus outbreak with Star Schlessinger. Paul then reflects on ISIS with Oliver Pouch on "Suck on That, ISIS." Hot Dog investigates the current uses of payphones on "NYSU Investigates." Joe Lunchpail talks about Iceland's plans to ban pornography. Paul and Hot Dog interview Troy Baker about his voice work. Paul interviews Rhys Darby about Short Poppies. Paul then talks to Oliver Pouch, Blue Crab, Star Schlessinger, and Rhys Darby about the War on Football.

Paul F. Tompkins discusses Nuclear Meltdown with Bo Beetle. Bigfoot talks about his opinion in the 2016 Presidential Election. Senator George Galapagos talks about the uproar revolving around Black Peter in the Netherlands. "A Bird" asks people on the streets about the Legal System. In "Small Story, Big Picture," Paul talks about a dead porpoise being found on the beach and was used in a prank. Ron Funches reads a letter from his past self as part of an experiment. Paul then talks to Bo Beetle, Princess, Senator George Galapagos, and Ron Funches about the Russia Gate as Gulag reports about the explosion in Russia.

As 2014 is almost over, Paul F. Tompkins discusses the Marriage Equality Movement with Barry and Gary. Dr. Mooz talks about the Health Issues of 2014. Paul holds a memorium for the words that are no longer used in 2014. Hot Dog talks about the 2014 Ferguson unrest incident as Paul Scheer of "Hush Now, Hush Now" crashes the program with Hot Link which results in Paul F. Tompkins beating Paul Scheer in a mental battle. Paul then talks to Star Schlessinger, Yed Nerp, Armond Mite, and Hot Dog about 2014 Winners and the 2014 Losers. Paul opens a gift from his Secret Santa with the gift being a Watson Tennis Racket with the Secret Santa being from the cast of "Hush Now, Hush Now."

Paul F. Tompkins talks about the New Year's Resolutions. Joe Lunchpail talks about old news on "News News." In "Get to the Point," Ned Cooper and Oliver Pouch talk about bringing back long-extinct species like woolly mammoths, dodos, and passenger pigeons where Ned is not given enough time to get to his point. Haardvark raps about the recent legalizations of marijuana in 25 states. Hot Dog tries to find a protest to report about in Los Angeles. Paul talks about the protests with Joe Lunchpail, Oliver Pouch, Haardvark, and Brian Posehn.

Paul F. Tompkins discusses the Great Pacific Garbage Patch with Bigfoot who is live at the location. Paul interviews "Weird Al" Yankovic where his hot dog publicist Judy is present and "Weird Al" accidentally hits Doug the Bat with a stick when he tries to ask a question. Paul and Professor Cornelius Nougat talk about Space tourism. Armond Mite talks about the trailers to The Second Best Exotic Marigold Hotel, Paul Blart: Mall Cop 2, and Star Wars: The Force Awakens. Paul discusses the Space Race with Ned Cooper, Star Schlessinger, Oliver Pouch, and Andy Kindler.

Paul F. Tompkins discusses the European Problems with George Rooney. Al Madrigal talks about his upcoming Fusion special "Half Like Me" while showing a clip of their project "Wait, What?!" with Hot Dog and Lady Wiener and later reads a letter from his past self. Chimp with a Limp talks about how his toyline was discontinued and the recent technological projects. Paul, George Rooney, Joe Lunchpail, Bigfoot, and Jonah Ray discusses the ideas about the next President of the United States.

As part of the upcoming Award Season, Armond Mite hosts his award show "The Mites." Andy Daly talks about his show Review and about the Life Hacks. On "Bo Knows," Bo Beetle talks about Don Lemon's on-air gaffes. On "Mooz on the Move, Street MD," Dr. Mooz talks to people on the street about their personal diseases. Paul, Bo Beetle, Steeewwww, Star Schlessinger, and Andy Daly talk about America's Christian Uncoupling.

Paul F. Tompkins gets an accidental transmission from Bob Odenkirk while announcing that Jeb Bush is getting involved in the 2016 Presidential Election. In "Slippery Slope," Joe Lunchpail talks about the artificial intelligence that Stephen Hawking and Elon Musk are supporting. Tim Meadows and Paul show off their different segments that involves Hot Dog, Lady Weiner, and Joe Lunchpail. In "A Bunch of Talking Boxes," Paul, Oliver Pouch, Laura Spots, Ned Cooper, Dwayne Johnson, Brigham Brigham, and Silent Banana are about to talk about the Keystone Pipeline with Speaker of the House John Boehner until Bob Odenkirk's accidental transmission interferes making the discussion not happen. Hot Dog hits the streets to talk about the man buns hair style. Paul, Joe Lunchpail, Oliver Pouch, Hot Dog, and Cameron Esposito talk about Barack Obama's legacy. Bob Odenkirk's latest transmission leads to a discussion on what smoke detectors sound like when they are low on battery.

Paul F. Tompkins talks about the measles outbreak with Chimp with a Limp. Rich Sommer talks about the final season of Mad Men and improvises the different recent stories with "Doggiestyles with a Z" (which Hot Dog, Lady Weiner, Hot Link, and an unnamed hot dog are members of). Felicia Day talks about her autobiography as she and Paul follow Twitter suggestions which Bigfoot and Ned Cooper get involved in. Paul, Star Schlessinger, Bigfoot, The Constitution, and Rich Sommer discuss the Death of Privacy.

Paul F. Tompkins shows the stage mom of the fake baby with him and then discusses Chris Christie being under fire with Oliver Pouch. Paul and Ned Cooper collect money for the Tom Petty Cash Drive. Keegan-Michael Key and Jordan Peele talk about their comedy life with Bigfoot helping Paul give Keegan the prizes for being the 100th guest on the show and partaking in "Opposites: Attack" with Bo Beetle and Star Schlessinger also taking part in it. Paul, Yerd Nerp, Armond Mite, Bo Beetle, and Greg Proops discuss the American Sniper controversy.

Paul F. Tompkins discusses the Yoga Pants Ban with The Constitution. Scott Aukerman talks about Comedy Bang! Bang! where he also reminisces about the 90s and re-enacts moments from the TV show Ski Lodge High with Paul, Steeewwww (who portrayed the character Desert Storm Larry), Lady Weiner, Princess, Mark McGrath, and Dennis Haskins (who doesn't believe that Ski Lodge High is a real show). Hot Dog interviews Dan Harris about his work on TV journalism. Paul, Dr. Mooz, Red Crab, Hot Dog, and Scott Aukerman discuss the anti-vaccination movement.

Paul F. Tompkins discusses about Tax Day as he burns his tax bills in the trash can. In "Cram," Paul discusses brief info with Professor Cornelius Nougat, Star Schlessinger, and George Rooney. Fred Willard talks about the latest trends. Bryan Fuller talks about Season 3 of Hannibal and answers questions from Bigfoot that revolve around Bigfoot's latest show. Paul, Star Schlessinger, George Rooney, Gary and Barry, and Fred Willard discuss social media.

Paul F. Tompkins discusses the defeat of the 24 Hour Bar Bill with Senator George Galapagos who started dating Lady Weiner. Ben Schwartz talks about Season 3 of House of Lies with Red Crab, Haardvark, and Paul rating Ben's impersonations. Chris Parnell talks about his web series "Star Talking." Paul, Blue Crab, Red Crab, The Constitution, and Chris Parnell discuss American Exceptionalism.

Paul F. Tompkins discusses human evolution with Dwayne Johnson upon finding proof of human evolution in the past. Chris Gethard talks about his show called The Chris Gethard Show which will air on Fusion and goes through the initiation that involves Chris being roasted by Armond Mite, Wade the Bat, Hot Dog, Chris repeating after "A Bird," and having to compete against Mike to keep their hand on Dwayne Johnson. In "Bo v. Wade," Bo Beetle and Wade the Bat compete about different current topics. Lauren Lapkus and Hot Dog review the latest apps on "Lauren Lapkus' App Kisses." Paul, Armond Mite, Hot Dog, Supreme Leader Meow, and Lauren Lapkus talk about the recent happenings to the world.

In "Hot Top Picks," Paul F. Tompkins, Ned Cooper, Oliver Pouch, and Star Schlessinger talk about the different topics of this week. Tim Heidecker talks about On Cinema and his "Working Work Out" exercises where one of them has him doing arm wrestling with Bigfoot as Joe Lunchpail and Oliver Pouch watch. Thomas Middleditch talks about Silicon Valley as he and Paul take off-topic phone questions from people. Paul, Haardvark, Dr. Mooz, Joe Lunchpail, and Thomas Middleditch talk about the Politics of Food.

In "The Cram," Paul F. Tompkins, Red Crab, The Constitution, and "A Bird" talk about the latest news. Matt Walsh talks about his role on Veep and takes part in "The News Wheel." Patrick Warburton shows Paul his food reviewing videos with video responses from Hot Dog. Paul, Star Schlessinger, George Rooney, Ned Cooper, and Matt Walsh talk about China overthrowing North America as a leading superpower.

In "Get to the Point," Paul F. Tompkins, Alicia Menendez, and Star Schlessinger talk about Ted Cruz's election and the final season of Downton Abbey. Joe Lo Truglio makes his way through the NYSU door (which had to be unlocked by Bigfoot) to talk about Brooklyn Nine-Nine, shows off his golf skills, and gives Paul cooking advice with Hot Dog's help. In "Three to Five Viral Questions," Paul and Tig Notaro answer viral questions. Paul, Red Crab, Armond Mite, Judy Goodstuff, and Tig Notaro talk about the shortage of the world's water.

In "Star's Wars," Star Schlessinger and Barry debate about the banning of gay people at a pizza restaurant. Wendi McLendon-Covey talks about Repeat After Me through her service person Darryl. Pete Holmes gives Paul F. Tompkins a plant as a gift and does a sheet cake-themed podcast talking about the latest episodes of Castle. Paul, Hot Dog, Senator George Galapagos, Dwayne Johnson, and Pete Holmes talk about the sharing economy. Kate Micucci and Riki Lindhome cover for Paul when he has to leave take part in a basketball game.

Paul F. Tompkins and Tiberius Coon III talk about "Project: Tiberian X" which is a time-travel experiment being developed by Coon Enterprises. Judy Greer talks about her role in Jurassic World and how she encounter Bigfoot in Paul's dressing room as well as experiencing strange clips occur during the interview. In "Speaking Frankly," Hot Dog interviews John Cho. Paul, Professor Cornelius Nougat, Senator George Galapagos, Tiberius Coon III, and Steve Agee talk about the one percent.

Paul F. Tompkins looks back on Season Three as part of the season finale. In "Hot Top Pick," Paul, Bierstin Krakov, and the Constitution talk about the featured hot topics. While providing the music, Jack Black competes against Paul in the brisk walking race with Jack losing to deal with Hot Dog's choking problem. Danny Pudi gets his face painted to look like Spider-Man and gets interviewed by Hot Dog about Community. Armond Mite, Chimp with a Limp, Snazz, and Danny Pudi talk about the rising cost of college and then roasts Mandy Patinkin with Jack Black's help. Paul, Jack Black, Hot Dog, Snazz, and Armond Mite sing their rendition of the "No, You Shut Up!" theme song.

Paul F. Tompkins talks about his two specials before Season 4 debuts on February 4, 2016 while counting down to the 2016 Presidential Election. In "Shut Up the Vote 2015," Paul, Star Schlessinger, Armond Mite, and Bigfoot talk about the broken debates. In "Make Sense," Dan Abrams talks via satellite about the issues with fantasy game gambling websites. Kristen Schaal talks about her views of the 2016 Presidential Election and takes part in "Wait, What?!" with Paul, Hot Dog, and Lady Weiner. Hannibal Buress talks about his special coming up on Netflix called Hannibal Buress: Comedy Camisado, his opinions on the political debates, and the effects of the 2015 El Niño. Paul, Star Schlessinger, Armond Mite, and Hot Dog talk about their "Wishues" (short for wish issues) as part of the 2016 Presidential Election.

In the second special, Paul F. Tompkins does "Shut Up the Vote 2015" with Star Schlessinger, Barry, and Dwayne Johnson revolving around Ben Carson's presidential campaign. Patton Oswalt announces his candidacy for President and talks about what he'll do when he becomes President while answering questions from Barry, Star Schlessinger, and Dwayne Johnson. Hot Dog talks about his trip to Politi-Con while showing footage of his interview with Ted Lieu. Paul gets a call from Donald Trump only to learn that he is talking to archive recordings of him. The "NYSU Vault" is opened during "No, You Look Back" so that they can look back to an older episode that aired on September 26, 1960 where the unnamed 1960s host, Mr. Carruthers, Mrs. Bramblecorn, and a faceless hot dog named Mr. Frankfurter discuss the First Kennedy-Nixon debate. Paul, Star Schlessinger, Dwayne Johnson, and Hot Dog talk about who to say shut up to in 2016.