The Busbys holiday in Florida as Danielle struggles with her health issues. Blayke's fear of the ocean impacts the Quints. Adam and the whole family plan a surprise wedding anniversary for Danielle. The Busbys brace for Hazel's next eye appointment.

Danielle searches for answers to her health issues, but what she learns could impact the whole family; the Quints must face their fears when they visit Santa; the family wants to give back to its hometown after the town is destroyed by hurricanes.

As the Busbys celebrate Christmas, Danielle prepares for an invasive test to determine whether she needs heart surgery; four of the Quints start ballet, the Busbys say goodbye to 2020 and Adam enlists the girls to make a surprise for Danielle.

With Halloween approaching, the Busbys scramble to make the holiday spook-tacular and safe in the pandemic; Riley's refusal to sleep in her room wreaks havoc; a hurricane threatens Lake Charles, forcing friends and family to evacuate.

As the Busbys get ready for a busy Thanksgiving, Danielle's health issues start to take centre stage. Blayke must face her fears when she has to get two teeth pulled. The Quints get a crash course on the importance of being thankful.

Blayke gets her big girl sleepover while the Quints invade Uncle Dale and Aunt Crystal's for the night; the kitchen renovation goes from bad to worse; the Busbys try to teach the girls to ride bikes.

Dale's positive COVID-19 test puts the whole family on edge. Back in quarantine with life on hold, the Busbys anxiously await their test results. Danielle learns the fate of the girls' upcoming school year.

As the Busbys' RV adventure continues, a storm threatens to ruin their fun. Hazel finally has her eye appointment, but the visit could mean bad news. With kindergarten looming, the Busbys face tough decisions that may upset the girls.

The Busbys are ready to salvage the rest of the summer when local quarantine restrictions are lifted; things take a turn for the worse when they discover a huge issue lurking in the kitchen walls; Parker faces an old fear; Dale surprises the family.

With the Quints fighting more than ever, the Busbys agree to join the Mills in San Antonio to shake things up. Meanwhile, Hazel is prescribed an unexpected treatment at her eye appointment, and Danielle faces her fear of heights.

The Quints get cash-crazy after the Busbys start them on an allowance; when Blayke joins the basketball team, Adam goes overboard to get her to be more aggressive; as Danielle's medical mystery condition continues, Riley faces her own visit to the doctor.