Pierce and Moretti uncover an international scandal while investigating the murders of a Bangladeshi diplomat and a Chicago reporter; Moretti struggles with the preparations for her upcoming wedding.

Pierce is called upon to help the FBI investigate the murder of a therapist. Moretti spends more time with Professor Hathaway. And Dean Haley uses Pierce as bait to get a wealthy alumni’s widow to fund a new building.

Pierce is enlisted to help crack the case of a murdered mail-order bride. A twist marks the investigation when it's discovered the prime suspect suffers from an unusual condition. Elsewhere, Moretti is drawn to a handsome new professor.

Donnie tries to help a war hero who suffers from a neurological disorder; Pierce is surprised by an old flame.

When a young man in a cult claims to be hearing the word of God, Pierce must determine if it’s actually the word of God or a life-threatening neurological condition. Pierce and Moretti must also figure out if his murder is linked to his drug past or his new life with an organization that may be scamming people out of their life savings. Roger Bart guest-stars as Ethan Kendrick, a high-powered IRS agent looking into the finances of the organization. Meanwhile, the university gives Pierce an award for his research.

A new brain device to control tremors seems to have a defect that turns out to be far more serious than a technical malfunction, and Pierce partners with Donnie to investigate. Their unlikely alliance is tested when the case escalates to murder. Meanwhile, Lewicki learns a valuable lesson about dating.

When Moretti receives a deathbed confession about the hit-and-run murder of a teenager from 1992, she calls on Pierce to determine the ailing man's credibility. The case becomes complicated, however, when the alleged killer's physician, Dr. Hutchins, reveals that his patient’s tumor has mysteriously disappeared. Pierce and Moretti must dig deeper into the past to uncover the truth behind a shocking series of apparent homicides.

Neuroscience professor Daniel Pierce (Eric McCormack) is recruited by a former student, FBI Agent Kate Moretti (Rachael Leigh Cook), to help out on a case involving the death of a pharmaceutical executive. But Daniel's schizophrenic hallucinations could potentially derail the investigation.

Pierce and Moretti race to find clues when a serial killer from 1986 begins killing again. They catch a break when they learn that one of the victims is actually alive. Moretti's dad, one of the investigators on the original case, offers his daughter advice. Pamela Reed also guest-stars as the mother of the surviving victim, while Armin Shimerman is the victim's psychologist.

Moretti and Pierce are called upon to solve a crime in their own backyard when a college student is killed in her dorm room. Pierce is forced into the uncomfortable situation of interacting on a personal level with more than one of his students, which forces him to confront difficult truths about his own past. The case comes just as Moretti is beginning to re-evaluate her relationship with Dr. Hathaway.

Pierce must take a deep look into his own life when he is brought into a case involving a schizophrenic. Meanwhile, Moretti stops at nothing to impress her new boss at the FBI. Guest star Tom Sizemore plays a top-level Irish mobster, while guest star Edward Furlong plays a would-be tough guy who may have played a crucial role in the crime.

Pierce tries to crack a coded message left in a newspaper by someone who may be connected to a murder. But time isn’t on his side as another victim’s life could be in danger.

A student tips off Pierce about a potential conspiracy to cover up the murder of a U.S. Senator.

Pierce investigates a stabbing at a psychiatric hospital and becomes convinced that the hospital is full of dark secrets.

Dr. Daniel Pierce’s picture-perfect new life in Paris is suddenly turned upside down after he is approached by the FBI legat to help with a dangerous international case. Meanwhile, his assistant Max Lewicki and Dean Paul Haley plot to get Pierce to return to Chicago.

Pierce and Moretti take on an extraterrestrial case when a woman reports that aliens have abducted her husband. When Pierce and Moretti arrive to investigate, however, they make a startling discovery. Meanwhile, things heat up between Pierce and his real-life girlfriend, Caroline, but his relationship could be jeopardized if he can't get his imaginary girlfriend, Natalie, out of his mind.

Moretti learns that there may be some truth to Pierce's conspiracy theory; Pierce's new doctor forces him to face the truth about Natalie.

Pierce accepts an invitation to work on a case from a renowned environmental activist concerning a chain of abnormal neurological reactions in a group of young girls. However, upon examining the girls, Pierce discovers that a dark secret is at the root of their ailments. Meanwhile, Moretti questions Pierce’s motives in working on a case without her.

FBI Agent Kate Moretti asks Dr. Daniel Pierce to determine the mental competency of a man being retried for murder. But the trial takes a shocking and unexpected turn when Pierce’s findings question whether the person standing trial is the same person he was six years ago. Meanwhile, Moretti is unpleasantly surprised to discover that the Assistant U.S. Attorney prosecuting the case is her soon-to-be-ex-husband Donnie Ryan.

Pierce and Morretti plunge into virtual reality to solve the murder of Kurt Simpson, a man who spent most of his time in a massive multiplayer online game called Caleidoscope. After creating an avatar of himself to investigate the crime, Pierce struggles more than ever to distinguish between reality and fantasy.

Lewicki's brother shows up unannounced; Kenny is named the key suspect in a homicide case; Lewicki is approached with an offer that makes him question Pierce's loyalty.

When renowned neuroscientist Landon Jennings is found dead, Moretti and Pierce must figure out how someone could have gained access to his impenetrable study in order to kill him. Lewicki finds himself with twice the work when Pierce’s father James moves in with them.

After Dr. Daniel Pierce suffers a traumatic injury, his father and his friend must decide if they should allow him to undergo a high-risk surgery; Pierce begins to question everything he sees and hears.

When a series of bizarre public murders occur, Pierce realizes that the killer is trying to send a message about inattentional blindness, but Donnie doubts this theory. But Pierce has a trick up his sleeve that can prove his point, and they must scramble to piece together the clues before the clever killer can make any more examples out of innocent victims.

Moretti faces criminal charges after taking matters into her own hands on a dangerous case; Pierce and Donnie try to clear Kate's name.