Perry drives to the scene of a shooting and finds the police recovering the body of Harry Merrill from a car that went over the side of a mountain. MerriIl has a bullet in his body and a pillowcase over his head. Meanwhile, Perry's client, Evelyn Bagby, claims she was chased by a hooded man in a car near the same cliff that day. She fired two shots at the man's car to scare him off, and now the police want her for murder.

Carla Adrian is having trouble fending off amorous neighbor Mark Cushing. When another neighbor hears a shot and a woman's scream, then witnesses Carla's Mother, Belle Adrian, in Mark Cushing's cabin—it's not long before the police discover Cushing’s body and arrest Mrs. Belle Adrian.

Fay Allison is getting married in a few days to Dane Grover. Her roommate, Anita Bonsal, is having a clandestine affair with a married man, Carver Clement. When Aunt Louise arrives early the next morning to be with Fay, she finds Fay and Anita both appear to have been drugged. Louise calls her friend Perry Mason to help decide what to do. Perry and Della discover the key to another apartment in Fay's purse and go upstairs to investigate. They arrive to find Carver Clement dead in the apartment. Fay Allison is accused of the murder when the police find her fingerprints on a glass in the apartment.

Perry receives a telephone call from George Beaumont, a man who supposedly died in a plane crash nearly three years before. In reality, Beaumont missed the plane and after hearing about the accident decided to disappear leaving wife Laura with his life insurance money. Since then, Beaumont has been cavorting with girlfriend Ruth Whittaker and living under an alias. He has grown tired of this life and wants to return home but someone cuts short his return by sticking a letter opener in his back. Ruth is then charged with the murder.

Rhoda Reynolds is charged with murdering her blackmailing ex-husband, Arthur Kane. At the trial, Perry moves the proceedings to the room in which Kane was murdered in order to re-enact the fatal night.

When Robert Crane is charged with the murder of his sister's estranged husband Perry needs the testimony of sister Helen Reed to clear him of the charge. Unfortunately for all concerned, Helen suffers from multiple personality disorder and the second personality, Joyce Martel, is the one who is needed as the witness. Helen's psychiatrist puts her under hypnosis so Joyce can tell what she knows about the case.

Jim Ferris is having an affair with his uncle's bored young wife. They concoct a scheme to finagle $80,000.00 from the uncle by faking a kidnapping. Things go horribly wrong when secretary Betty Wilkins, acting as a go-between, is charged with the murder of Jim Ferris.

A nasty actor with a lot of enemies is murdered. Perry gets his accused killer off the hook but then HE turns up dead and an aging, eccentric actress is blamed for that one. Are there two murderers on the loose or are both the work of one person?

Della asks Perry for $25,000 for her friend Janet Brent, who is being blackmailed. Edward Franklin, an employee of Janet's husband, has staged compromising photos of her in a motel. At a party, Janet confronts Franklin and hits him with a small statue of a "weary watchdog." The police arrest Della when they find her driving Janet's car from the scene of the argument. Franklin is dead, struck three times on the head with the statue. Perry defends Janet knowing that if he loses, Della will go to prison as an accessory.

The Safeline Insurance Company notices an increase in heart attacks among their policy holders. The company suspects fraud and hires Perry and Paul to investigate. When Paul goes undercover as a construction worker, he almost doesn't survive the assignment.

A judge is accused of murdering a government witness who planned to expose him as a crook.

An art dealer and his girlfriend are arrested for a two murders related to a series of hijacks. Paul goes undercover to ferret out the hijacking ring and Perry finds himself staring face down the barrel of a gun pointed by a killer even he never considered.

A young widowed high school English teacher in a small town is accused via letter of making passes and more towards some of her male students. But a small town is small town and it seems that all the key figures are involved somehow, the principal, the lawyer, the doctor, the local barkeep, and of course the oldest boy, who's really more of a man, in the high school.

A promoter's plan to frame his wife and business partner for embezzlement fails, but they're arrested anyway for his murder.

Perry and the team investigate the murder of an antiquarian bookseller with an interest in forgery.

Dr. Stacey Fielding takes off for Salt Lake City on business. When his plane crashes, Veronal poisioning is found in the body. Miriam Fielding is arrested since the last thing the good doctor drank was whiskey from a flash she had given him. Upon further investigation, Miriam is cleared when it's discovered that the man who really perished in the crash was Al Dolby, the plane mechanic. But where is Dr. Fielding and who did the poisoning?

Perry Mason finds himself the target of an attempt to discredit him while he is in the middle of a major lawsuit.

Young cop Jimmy Anderson, cousin of Lt. Anderson, and veteran Otto Norden come across a robbery at the Wilson Plastics Company while on patrol one night. A shooting occurs and Otto is killed. Evidence then points to Jimmy as having been an accomplice in the burglary and he is suspended from the police force. Then the night watchman at Wilson Plastics, a disgraced ex-cop, is found strangled to death. Lt. Anderson then asks Perry to look into things and defend Jimmy against all charges.

On trial: the estranged wife of a professor who's written a lurid novel.

Mason goes to the dogs when his defense of a murder suspect hinges on a surprise witness.

The ex-wife of an author who has written a lurid expose and is murdered.

Carla Chaney is caught seemingly red-handed at the scene of the murder of her ex-boyfriend. Perry agrees to take the case pro bono after three other attorneys drop out. Carla's only hope is an unseen woman she claims was also present at the scene. According to Carla, this woman had a sinister laugh.

A fortune teller gives a series of accurate predictions regarding a woman's future. But something goes wrong when she's charged with murdering her new husband.

Perry rescues Diana Carter from the ocean in his boat and then must rescue her twice more in the courtroom. Once for jewel theft and once for murder.

A chronic shoplifter later finds herself charged with murder. Her niece hires Perry for the defense.