After successfully freeing the Detroit Lions from "The Curse of Bobby Layne", Peyton Manning gets ambushed by former Buffalo Bills wide receiver Steve Tasker and The Bills Mafia, who demand Peyton lift "The Buffalo Sports Curse". After hearing their pleas, Peyton meets up with Bills quarterback Josh Allen as they attempt to lift the curse.

Peyton Manning heads to Philadelphia, where he switches places Freaky Friday style with former Eagles center Jason Kelce to learn about the history of the quarterback sneak. Peyton becomes the center of attention as he experiences the Tush Push from Kelce's perspective.

Peyton Manning heads west to Malibu, CA, to meet up with Chargers head coach Jim Harbaugh to help him spend a day in his favorite TV show, The Rockford Files, climaxing in a wild ride along the California coast that would make Jim Rockford proud.

When Peyton can't quite explain the NFL's Passer Efficiency Rating to a math class at his alma mater, the former Tennessee Volunteer enlists the help of Falcons quarterback Kirk Cousins to get to the bottom of the NFL's most confusing statistic.

When Patriots owner Robert Kraft asks former Patriots Rob Gronkowski and Julian Edelman to pay for damages to New England's Super Bowl LI Trophy, Peyton takes them to Rhode Island where the trio try to build a Lombardi Trophy from scratch.

OMAHA! Peyton Manning goes through the history of quarterbacks calling their own plays and the invention that made playcalling the coach's job, with help from Cincinnati Bengals QB Joe Burrow and former Bengals QB Boomer Esiason.

Long before there was the Practice Squad in the NFL, there was the Taxi Squad. Peyton Manning and four-time NFL All-Pro James Harrison take a ride to learn more about how the Practice Squad started with a taxi in Cleveland.