Mr. Itch offers Brain control of the world in exchange for his soul, but Brain refuses. In a shocking twist, Pinky sells his soul to make it happen and Brain soon decides to get his friend back.

The mice make a series of comedy films and hit the big time.

After the Earth gets the power of speech from his Silitronlinguifactor device, Brain comes up with a new plan.

Brain is out of ideas for taking over the world, so he tries to get some from writers.

A well-meaning tailor makes Pinky and Brain's lives miserable.

Pinky and Brain have a new companion, Larry, but their newest plan just doesn't seem to pan out.

Brain tries to get a package meant for him back from his neighbor.

Pinky becomes a guru during the 1960s.

It's Brain's birthday and Pinky plans a surprise party.

The mice are looking to control tornados, but a pest keeps getting in their way.

To save his Las Vegas casino, Brain works as a lounge singer.

Brain's attempt to control Emperor Franz Josef get side tracked when he talks about his problems with psychiatrist Dr. Sigmund Freud.

Brain takes control of a satellite to air his infomercial around the world, but the satellite belongs to the military and they want to capture whoever hacked into their systems.

Brain tries to change the Earth's weather patterns.

It's 1946 and Brain's new plan gets interrupted when he and Pinky encounter Billie and Snowball.

After getting a glimpse of his future, Brain abandons his attempts to take over the world and gets a job as a ski instructor.

Brain masquerades as a fashion designer.

Brain plans to use the Personalitron to give him irresistible charisma, but it winds up going to Pinky.

Brain assumes the identity of Briany Jack, a hippie leader, and tries to create a peace chain to send a subliminal message.

At a sleep away camp for world leaders' children, Brain tries to trick the children into placing listening devices in their parents' offices.

The mice need to get into a mine, but have to pretend to join a Amish-type society.

Brain becomes a tap dancer with steam-powered legs in order to spread a subliminal morse code at the World's Fair.

Farmer Brain tries to grow an army of monster vegetables.

Brain creates a cloning machine and plans to clone himself in order to create the best Celtic dance troupe the world has ever seen.

A house needed for Brain's latest plot becomes the set of a reality series about the people living there. So the mice become participants to get in.