Pinky and Brain are kidnapped in Washington, DC by an unknown force. Brain loses his memory and the mice are then imprisoned in a town where everyone is forced to perform the Schëerskåhøvên, which is dumbing down the entire country.

Brain regains his memory and the mice escape. They believe Snowball is responsible for the Schmëerskåhøvên, but him imprisoned in a mental institution.

Inspired by legends of the past, Brain tries to create a legend about himself to gain world acclaim.

Pinky sings about cheese.

Mr. Itch offers Brain control of the world in exchange for his soul, but Brain refuses. In a shocking twist, Pinky sells his soul to make it happen and Brain soon decides to get his friend back.

The mice and Snowball search for the one who spliced their DNA, Dr. Mordough, thinking he's responsible for all this. But it turns out to be his cat, Precious, and time is running out.

Brain comes face to face with his former friend and now enemy, Snowball. And it seems Snowball has his own plans to take over the world.

Brain makes a tearjerker movie to make the world sad enough to make him leader.

The mice make a series of comedy films and hit the big time.

Brain hopes his inter-galactic pen pal, Zalgar, will help him take over the world. But it turns out Zalgar likes to snack on brains.

When Brain comes to the conclusion he no longer wants to take over the world, he decides to help others who had his problem and the first one to be helped is Pinky.

Pinky and Brain have a new companion, Larry, but their newest plan just doesn't seem to pan out.

After the Earth gets the power of speech from his Silitronlinguifactor device, Brain comes up with a new plan.

Brain is out of ideas for taking over the world, so he tries to get some from writers.

To save his Las Vegas casino, Brain works as a lounge singer.

Brain takes control of a satellite to air his infomercial around the world, but the satellite belongs to the military and they want to capture whoever hacked into their systems.

A well-meaning tailor makes Pinky and Brain's lives miserable.

Pinky and Brain's plan to alter caviar with a mutating capsule is complicated by a Russian lab mouse.

Brain plans to take over the world by creating a voice mail system that will tie up everyone on the planet long enough for him to take over. In order to do this he needs money. He decides to get it by getting a job and then staging an accident in order to sue the company.

The Brain hatches a plan to take over the world by using static electricity to shock the world into submission. Unfortunately he needs several billion dollars to build a giant clothes dryer. Pinky and the Brain head to Island X where they set up a fake country and hope to get a giant foreign aid loan from the United States.

Brain tries to get all the people off Earth onto his paper mache creation, Chia Earth.

Brain tries to get a package meant for him back from his neighbor.

Pinky becomes a guru during the 1960s.

The mice are looking to control tornados, but a pest keeps getting in their way.

Brain's attempt to control Emperor Franz Josef get side tracked when he talks about his problems with psychiatrist Dr. Sigmund Freud.