When the original Anomaly in the Forest of Dean reopens and a string of disappearances plague the area, Helen Cutter returns with a warning for Nick Cutter and the team about the deadly, elusive new predator the team are struggling to track: it is not a creature from the past, but from the future. Nick and Helen both want to go on an Anomaly containment mission into the past to stop the future from altering it, which ends in terrible consequences.

While Sarah and Becker deal with a Megopteran attack at Johnson's old HQ, Danny, Connor and Abby return to the future to stop Helen; the trio soon learn the truth behind Helen's master plan, and are sent on a race through the Anomalies to stop her before she ends humanity at its beginning.

Matt and Abby go through New Dawn's Anomaly on a rescue mission for Connor into the barren, Predator-ruled wastelands of the future, while back in the present, the future apocalypse looms closer as New Dawn spirals out of control. Meanwhile, Jess and Lester face problems of their own when the ARC is invaded by Mutated Future Predators.

While Stephen deals with a Silurian Scorpion attacking a popular beach resort, the team are trapped in Leek's bunker with an army of creatures. When the creature army escape and run amok in the bunker, the team must both escape the overrun bunker with their lives and stop the creature army from escaping onto the modern world.

The team are sent to deal with a Columbian Mammoth rampaging on the M25, and attempt to save a trapped motorist before she frightens the Mammoth into attacking again. Meanwhile, Connor and Abby search for the missing Rex and Caroline, and Stephen reveals his alliance with Helen Cutter. Connor and Cutter spring their trap to find the traitor in the ARC, and Oliver Leek's true colours are exposed and the team race to track him down.

A year after becoming marooned in the past, Connor and Abby return from the Cretaceous to a changed and upgraded ARC, but Connor accidentally brings a Spinosaurus back to the present with them.

The team head to an old prison, where they discover an Anomaly that won't lock and is producing satellite Anomalies throughout the prison, which in turn makes it even harder for the team to track a Terror Bird loose in the prison. At the same time, Danny returns from the past with a warning for the team, Ethan's true identity is discovered, Emily is torn between Matt and the chance to return to her home, Matt reveals his secret, and Connor makes a terrible discovery.

With Convergence having finally arrived, while Becker and the entire ARC struggle to contain an increasing outbreak of numerous Anomalies and creatures, New Dawn begins to power up for its final phase, as the team struggle to stop Philip from activating New Dawn before it's too late.

As Cutter struggles with losing Claudia Brown and with the other consequences of the failed mission into the past and tries to get the team to see that history has been altered, the team are sent to a shopping mall to contain an infestation of deadly, ruthless Raptors. Arguments among the team intensify when Cutter wants all the Raptors tranquilised and sent back through the Anomaly alive.

Cutter's new Anomaly predictions lead Jenny, Connor and Abby to a reputedly haunted abandoned house, where they soon learn that the Anomaly incursion dates back fourteen years and the house is inhabited by a deadly Camouflage Beast. The team also have to deal with the antagonistic suspicions of Detective Constable Danny Quinn on their interest in the house.

Cutter and the team head to a hospital to deal with an Anomaly and a Diictodon colony wreaking havoc on the hospital's power supply, and also have to help deliver a baby and stop a greedy journalist from getting proof of the creatures. Meanwhile, Helen Cutter and her clone army launch their attack on the ARC, and Helen reveals a secret about the future to Nick.

When Johnson takes Lester's control over the ARC, the team are forced to flee into hiding from Johnson's forces at an abandoned rural military outpost, where they come under attack by a pack of bloodthirsty Terror Birds.

As the team emotionally struggle to recover from the aftermath of Helen's attack, Jenny leads the team to a new Anomaly at an airport; where a Giganotosaurus or "G-Rex" threatens the crew of a Boeing-747, a news crew are attempting to document the incursion for the media, and Danny Quinn gives the reluctant team his unwanted help.

The team learn the truth about New Dawn when Connor creates an artificial Anomaly in the ARC, and trouble soon erupts when the Anomaly unleashes swarming, carnivorous beetles from the future into the ARC, which trigger the lockdown but threaten to burrow out and swarm onto the modern world. The situation is only exacerbated when the beetles trigger Jess' deadly allergy to insect bites, and when Philip threatens to incinerate the entire ARC to stop the beetles.

When a boy's disappearance down a drain coincides with an underwater Anomaly, Stephen and the ARC search the local canal for the aquatic predator behind the disappearance, while Cutter is convinced the creature is somewhere else. Cutter turns out to be right in the worst possible way when Abby is taken by Mer Creatures from the future and held captive in a flooded warehouse cellar. Meanwhile, Cutter and Connor learn that there is a conspiracy within the ARC.

When a young London girl chases her dog through an Anomaly into a harsh, prehistoric desert world, Cutter and Stephen go through on a rescue mission for the girl, but find themselves up against giant sand scorpions. The team's problems only worsen when the Anomaly closes on the trio and leaves them marooned in the hostile desert world.

The team investigate when an Anomaly opens in an Ancient Egyptian artefact at the British Museum, and when a Pristichampsus comes through, Cutter, Abby and Jenny are sent into a race after the giant crocodilian through Central London. Meanwhile, Connor and sparky Egyptologist Sarah Page discover that the Anomaly, the artefact and the creature hold an incredible ancient secret.

Jenny and the team, with unwanted help from Danny, attempt to stop London from becoming engulfed by a pandemic when they face an incursion of a deadly, fast-spreading fungus from the future that turns its hosts into primal monsters. Meanwhile, Sid the Diictodon has escaped Connor's custody into the ARC and is causing calamity, and Jenny learns the truth about Claudia Brown.

Jack searches for answers about Abby's secret life, and gets chased through an Anomaly by a deadly Megopteran; forcing the team to go through on a rescue mission into the desolate, predator-filled ruins of the future.

While the rest of the team deal with a herd of Embolotherium that threaten a rural racing campsite, Danny goes on an infiltration mission to rescue the mysterious Eve from Johnson's forces. But when the team soon discover who Eve really is, her rescue from Johnson has disastrous consequences.

While Connor and Abby try to earn their old positions on the team back, Connor reunites with his old friend Duncan, who leads Connor to a series of homeless killings at a dock area that the team discover are the work of an elusive and deadly Kaprosuchus.

The team investigate an Anomaly incursion at a rural manor house, and reunite with Jenny and discover that the manor is the location for her wedding in the morning; forcing the team to contain a pack of Hyaenodon while ensuring Jenny's soon-to-be-husband doesn't find out. Meanwhile, Jess and Becker are caught in Ethan's deadly trap.

Helen Cutter directs the team to an Anomaly at a football stadium and escapes through, leaving behind a flock of Dodos. The team soon discover that the Dodos are host to a deadly parasite, and struggle to stop a pandemic when Tom is infected and - convinced that the government are incubating a mind-controlling biological weapon inside him - goes on the run from the team.

The team investigate the brutal death of a golfer at a golf course, and discover an aerial Anomaly and a Pteranodon in the skies above. Claudia is convinced that the Pteranodon is responsible for the golfer's death and wants deadly force used against it, but Cutter and Stephen are convinced otherwise. Cutter's suspicions are confirmed correct when Claudia is trapped in the golf course's clubhouse by a deadly, flesh-eating swarm of Anurognathus. Meanwhile, Connor accidentally frees Rex from Abby's flat, forcing Abby and Connor to chase Rex across the golf course.

Cutter struggles with the arrival of the ARC's new PR guru, Jenny Lewis, who is physically identical to the lost Claudia Brown, yet is temperamentally a completely different person with no idea of her doppelganger; while Connor gets picked up by a beautiful young woman who is everything he is not, but Abby and Rex are both suspicious of her; and Stephen begins seeing Helen again. When an Anomaly releases a yellow, sulphuric mist inhabited by giant, carnivorous worms on a gleaming new high-rise office block, Cutter and Stephen are sent in to deal with the deadly creatures with Jenny, while back at the ARC, Connor and Abby try and find a fog-battling weapon.