When a girl is raped on campus in circumstances identical to an unsolved case from 10 years previously, inspector Donckers calls upon her former psychological criminology Professor T to help crack an impossible case. Simultaneously expert and eccentric, his curious methods ruffle a few feathers along the way.

A university's chief librarian is poisoned, police believe he may have been the wrong target and their fears are confirmed when they discover another victim. Professor T is summoned to help solve to help solve the crime, to the horror of Chief Inspector Rabet who is yet to be convinced by his controversial ways.

A plastic surgeon is killed and the police are looking for a woman he spent the night with. Professor T believes she is innocent but Commissioner Flamant has forbidden her team to contact him for help. Professor T begins his own investigation, with serious consequences. Meanwhile, Annelies, agrees to go on a date with Daan and Professor T's mother becomes increasingly concerned about her son.

The chairwoman of the school's inspection team is murdered at home. At first sight, it looks like a robbery gone wrong but Professor T is convinced the school principal is somehow involved. Annelies and Daan confront Rabet over his increasing drink problem but agree not to tell the commissioner. Annelies meanwhile, opens up to Daan about her father's Alzheimer's.

There is a hit on prominent businessman Johan Verhulst during an official happening. The shooter fails. A few days later a lot of blood is discovered in his upside down turned living-room, but there is no body. Verhulst has disappeared. Jasper deducts everything is staged by Verhulst himself, but then he is found dead after all.

The police investigate the disappearance of a first-year law student with several secrets to hide. Meanwhile, Professor T is visited by a call girl and make a special arrangement. Due to her erratic behaviour, Daan begins to suspect Annelies has a boyfriend but she soon puts him straight. Meanwhile Inspector Rabet's drink problem is getting worse and Annelies loses her temper.

The kidnapping of a six-year-old boy shocks the team who endeavour to do everything they can to find him. However, Professor T, questions the innocence of his seemingly distraught parents. Professor T's Mother invites him to present at the opening of her art exhibition, a prospect he is dreading. Rabet finds himself subject to a formal enquiry following the miss-treatment of a guest inspector.

A student suffers life-threatening injuries as the result of an arson attack, and quite a few people appear to have motives for the attack. Dr. Gijselbrecht sets Professor T an assignment, however Professor T has other concerns. It has been decided that Professor Van der Weyden will continue to teach Professor T's course, but Van der Weyden has a secret.

Having witnessed more poor teaching by Van der Weyden, Professor T is at his wits’ end and comes up with a plan to pretend that he is considering a job offer at a different university. Annelies realizes she can no longer take care of her father on her own, and has some tough decisions to make. Annelies and John are collaborating successfully, but Annelies still has her guard up.

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The call girl who visits Professor T is found dead in her apartment. The police believe she has committed suicide, but Professor T is not so sure and hides the fact that he knows the victim to stay on the investigation team. Inspector Rabet is back and he hasn't forgotten that Professor T betrayed him in front of his colleagues and Annelies and Daan are not speaking to each other.

Chief inspector Rabet gets into serious trouble when he's confronted with the man who killed his daughter in a car crash. The man in question is thought to be involved in a crime and while Rabet is certain he's guilty, his colleagues are less convinced. Meanwhile Professor T is taking oral exams and finds an unlikely investigation aid in one of his students.

A man is accused of killing his boss, having been found standing over the body, Annelies and her investigation team are convinced he is guilty. However, following a presentation by Annelies to his students, Professor T has questions if they have the right man. Flamant finds herself in hot water, sparks fly between Daan and Annelies.

After six months in an institution Professor T is released on one strict condition. Daan returns to the office, but things are not easy and Annelies' guilt puts their relationship under strain. However, the old team are back, and their help is needed; a number of fatalities have been linked to eating poisoned sweets, and the trail leads to the manufacturing company.

A series of attacks have been carried out on SUVs. At the same time, pamphlets are being distributed for an anarchist student group which Professor T was once a member of. Professor T invites Flamant to his home for dinner which does not go as planned. Daan's replacement John joins the team; he is certainly an asset and proves intelligent enough to compete with Annelies.

When a woman's body is found 100 meters from where her car fell into a deep canal, the cause of death seems clear. However, when it is discovered that her injuries were not caused by the accident the team struggle to come up with an explanation. Professor T receives a blow to his ego as Annelies struggles to accept her father's fast deterioration.

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A physician, his wife and two children are found dead. It is unclear to the team which one of them was the killer of the other three and therefore which of them committed suicide. Professor T is having nightmares and suffering from hyperventilation; is this a result of his therapy? Annelies makes a shocking discovery about her father and Rabet receives startling news.

A jeweler's family is taken hostage while the jeweler is on his way to empty the safe at his shop; an accident en route raises suspicion. Professor T is going through a rough patch and considers quitting therapy. Not only has he been unable to prevent a fatality, he's also admitted to hospital after an accident at a public swimming pool. Since his departure, Flamant has assumed Rabet's duties.

Jitske, a 17-year-old girl with Down syndrome, claims she knows who murdered her mother, but she doesn't want to say who it is. When Annelies shows insensitivity towards the girl, John decides it's time for her to meet his daughter, Elke. Professor T finds that Flamant is being overly friendly and it is making him nervous, especially when she confides in him about her upcoming divorce.

Professor T's classes are proving popular. The material he presents is like a thriller that has the students on the edge of their seats and they start flocking to his class in increasing numbers. Annelies receives confirmation that her father's euthanasia request is legally valid and that she has been named trustee. Struggling with this heartbreaking decision, she turns to John for support.

An undercover agent, who is embedded in the drug scene, is found dead in the trunk of his car. The target of the investigation is drug lord Mark Desmedt, but could this be too obvious a suspect? At the university it is Professor T's birthday, catalyzing his odd behavior and visions. Meanwhile Annelies' career comes to a crossroads and she makes a big decision.

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