Connor Doyle, the team's case manager in the first season comes back from the dead, but this time his intentions are not all good.

Case File # unknown Donner and Stone are caught in a sinister plot when they investigate a rave club overrun by zombies.

Case File # unknown An old man following three Old West outlaws is actually Axon 30 years in the future, warning his younger self against inventing time-travel.

Case File #098-509 Peter Axon and Frank Elsinger run tests on an electromagnetic field (EMF) laser cannon in the lab at Tessler Industries to destroy a missile guidance system. After the experiment fails when the laser device overheats, a janitor resets the cannon and destroys the missile guidance system.

Case File #145345 The Office of Scientific Investigation and Research is called into action when the mutilated corpse of a police detective who gunned down an escaped convict is found in a dumpster.

Case File #392-101 Tessler Industries, a video-game giant, is testing one of its new virtual-reality war games at the Office of Scientific Investigation and Research Central Lab. When a woman is knocked to the floor with a very real head wound, Elsinger calls for the O.S.I.R. team to investigate.

Case File # unknown A journalist's relationship with a Death Row inmate causes a rare haunting.

Case File #828-456 The Office of Scientific Investigation and Research investigates the unusual death of a large South American rodent called a capybara at the Windsor Animal Hospice.

Case File # unknown The team's investigation of a woman's precognition of her own death leads to a shocking discovery.

Case File #751718 Following a memorial service for Dr. Anton Hendricks the Office of Scientific Investigation and Research team members receive an anonymous phone call informing them that Hendricks is at a nearby hospital unconscious and on a ventilator.

Case File #659-311 The Office of Scientific Investigation and Research case manager Matt Praeger, security co-ordinator Ray Donahue, chief science analyst Peter Axon and senior data analyst Lindsay Donner visit the scene of a grisly, pre-Halloween murder of two college students who died after having their faces torn off.

Case File #298-321 Peter Axon is working on a secret project for the Office of Scientific Investigation and Research head Frank Elsinger that seems to have special and very personal significance for Elsinger, who assigns case manager Curtis Rollins to provide security for Axon as he finishes the project, which involves mapping out an anonymous individual's genetic code.

Case File #226-051 The Office of Scientific Investigation and Research senior data analyst Lindsay Donner and pathologist Claire Davison are called to the Newgate Correctional Facility after an inmate dies mysteriously while in solitary confinement.

Case File #600-001 The Office of Scientific Investigation and Research investigates after the body of an elderly woman is found in the basement of a soon-to-be demolished apartment building.

Case File #898777 When a forest area turns into a bone-dry wasteland virtually overnight, a government agriculture official turns to the Office of Scientific Investigation and Research for help.

Case File #333-016 The Office of Scientific Investigation and Research team investigates after an auto shop teacher at Royalton Custodial School is crushed against a wall by a car. The ""accident"" could be the work of a student with telekinetic ability.

Case File #899-997 The Office of Scientific Investigation and Research is transporting a young woman who's had an alien encounter, when their van is engulfed in a bright light from a UFO, temporarily blinding the investigator, and the woman disappears.

Case File # unknown The O.S.I.R. investigates a plane crash and its survivors, who have been in a sort of limbo since their disappearance 10 years ago.

Case File #569-977 The Office of Scientific Investigation and Research case manager Matt Praeger is institutionalized after a case goes tragically wrong. Working undercover as an arms dealer in order to gain access to a teenager with ESP Praeger gets caught in the middle of a double cross and apparently fires the bullet that kills the youth.

Case File #340-872 Archaeologist and former lover of Lindsay Donner finds a 13th century burial shroud inside an ancient Druid coffin. At his request, Donner and the Office of Scientific Investigation and Research team join him in London to verify the authenticity of the ""winding cloth"" and identify the man buried in it.

Case File # unknown A doctor's mission to colonize a new world forces Matt to make a decision about his future.

Case File # unknown Axon must race against time to save the life of an alien grounded in a meteor crash.

Case File # unknown An autistic boy develops psychokinetic abilities while mourning the death of his twin brother.

Case File # unknown Oil drilling in an ancient tribal burial ground unleashes a demon killer.

Case File #222-989 The Office of Scientific Investigation and Research investigates after a UFO is sighted in the woods near the private community of Poplar Glen.