After the Turtles stumble across a pizza restaurant in the mystical Undercity while following a Fire Yōkai, Leonardo drags his brothers into a pizza-shaped Maze of Death to obtain the ultimate prize....a free helping to the titular parlor's "world's greatest pizza". But in order to claim it, they will have to contend with the pizza's guardian in the form of the Minotaur who is the maze's assistant manager.

The Turtles have a hard time watching their skateboarding idol Sydney Allen on the "Extreme Skateboarding Finals" and stopping a burglary at Gilbert's Department Store conducted by the Foot Clan at the same time.

Leo, Mikey and April investigate a mysterious specter haunting a themed supermarket called Stock 'n Shop, which leads to their encounter with Baxter Stockboy.

April and the brothers make Raph face his greatest fear: an adorable kids' TV show rabbit named Mrs. Cuddles. However, things aren't so funny anymore when Mrs. Cuddles suddenly comes to life and begins hunting the Turtle family to feed on their fears.

Hypno-Potamus returns and causes havoc at April's homecoming dance by hypnotizing the attendees.

After an unfortunate glue accident, the Turtles have to fight a whole host of villains like the Mutant Silverfish, the Foot Clan, Hypno-Potamus, and Warren Stone while literally being stuck together.

The Turtles look for a way to eliminate New York City's Oozesquito problem.

The Turtles plan their first public musical gig at Albearto Land. When it happens, it gets crashed by Albearto and his army of animatronic bears from failed Albearto's fastfood franchises.

The Turtles end up facing a new and dangerous threat in their beloved city as Baron Draxum, Huginn, and Muninn gather some of their toughest mutant enemies like Meat Sweats, Hypno-Potamus, Warren Stone, Repo Mantis, and the Sando Brothers in a plot to destroy them.

During a visit in April's school, Donatello becomes enamored with an exclusive tech club, the Purple Dragons, and joins them on the spot. However, when the Dragons abuse his tech for criminal purposes, Donatello is forced to choose between stopping the crooks and losing his treasured purple membership jacket.

DIGG, a trio of unsuccessful girl musicians mutated into burrowing animals, begin sinking the Turtles' favorite pizza places into the ground, prompting the Turtles to go after them before they have no place left to get their favorite food.

To ease their household chores, Donatello invents a new artificial intelligence, S.H.E.L.L.D.O.N., who begins to see exclusively to his creator's needs. Disgruntled, Raphael, Michelangelo and Leonardo choose to rewire the robot, which leads to near-fatal consequences for their brother.

Mikey goes on a solo mission to retrieve a classic video game based on Lou Jitsu's film Hot Soup. Incidentally, however, he will have to contend with the Foot Clan's new recruit who is on a very similar mission at the very same auction house. Note: Ice Cream Kitty from the previous series makes a cameo as a statue.

The simple task of returning a single DVD just before its loan period runs out is complicated by endless craziness in New York, including an encounter with Ghostbear.

Things go sour when the Turtles try to help a down-and-out mutant in the form of the bellhop-turned-mutant bull from "Bug Busters" while at the same time planning a raid to obtain more of Big Mama's web goo. Bullhop eagerly decides to help his benefactors out.

Frustrated by his brothers' childishness during an important mission, Donatello enhances their intelligence. However, things get quickly out of hand when they begin displaying Donatello's personality traits as well.

When Michelangelo and Todd Capybara spy on Meat Sweats in order to learn his most delicious recipe, the Turtle and the mutant chef become BFFs after Meat Sweats accidentally absorbs Todd's niceness. The two of them go on a look for the extremely rare lunar truffle that only grows when the Moon is in alignment with Jupiter, and face its Were-Tree guardian.

Leo loses his brothers in a portal and must venture to the mystic Hidden City to save them. He finds that they are on the pirate ship run by Capitán Piel.

Raph becomes friends with a new sparring partner in the form of Frankenfoot and must keep it secret from his brothers, who don't like the guy. When Frankenfoot is driven from the lair, this gives the Foot Lieutenant and the Foot Recruit the opportunity to take it into the Foot Clan.

As the Turtles try to find pieces of a strange metal Baron Draxum is looking for, Splinter intents to get to the bottom of odd goings-on at April's new job at the Foot Shack. He soon learns that the Foot plan to resurrect their ancient master the Shredder by reassembling the Kuroi Yoroi armor. As the parties clash, the secrets of Splinter's past finally come to light.

Baron Draxum, Huginn, and Muninn want the gauntlet that Warren Stone has since it's part of the Kuroi Yoroi armor, but he's not giving it up without a fight and a side of betrayal. As the Turtles get involved with Warren's roommate Hypno-Potamus being threatened, April remembers who Warren Stone is as she was part of a fan club dedidicated to him called the Stoneheads.

Leo and Donnie try desperately to help April enjoy a quiet day with a new friend named Sunita. They learn that she is a slime Yōkai who uses a special amulet to turn into a human. They soon get targeted by the Foot Clan since the boots that Sunita's human form is wearing are part of the Kuroi Yoroi.

Señor Hueso has just remembered that an ogre gang called the Makers of Brutality and a reptilian gang called the Makers of Barbarianism have book reservations at Run of the Mill Pizza. While helping Señor Hueso at Run of the Mill Pizza since his employees have fled, Leo and Mikey get sidetracked by brotherly competition. They must overcome this to keep the peace while trying not to wreck Run of the Mill Pizza.

Baron Draxum struggles to move up the ladder in the Foot Clan while Foot Recruit was displeased that she hasn't gotten her mark yet. Upon finding a loophole where a Foot Clan member who can outdo an acting leader can assume this position, Baron Draxum leads the Foot Recruit into organizing a blunder for the Foot Lieutenant and the Foot Brute when the next Kuroi Yoroi fragment is at the botanical gardens. Meanwhile, the Turtles hold a contest to see who can withstand the smell of the corpse flower at the same botanical gardens.

The Turtles plumb the depths of a mysterious hidden library in search of a way to rescue Mayhem from April's mirror. While trying to be quiet, they must also evade not having a sound heard by the Bat Librarian's Hush-Bats and contend with the Foot Lieutenant and Foot Brute.