A new captain shakes things up at the East Miami Police Department, and Miami's young, hot-shot mayor gets personally involved when his promising young mentee is mysteriously murdered.

When Rosie and Villa discover that their murder victim has a death certificate from three years ago, they’re charged with uncovering the truth around his identity. As they struggle to solve the mystery around his death, as well as around Eddie’s, TMI tries to reconnect with Pippy and Donna finds it hard to keep a secret from her family.

An old flame of Rosewood's shakes up Rosewood's life when she returns to enlist his help in finding a wealthy patient of hers who's disappeared. But when the man's body surfaces, triggering a murder investigation, things are not what they appear to be. As the bizarre turns of this case come to a head, so does Rosewood's personal life as he is pushed to make decisions regarding all the women in his world.

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When pathology students work with the team on a cold case, their findings impact the entire Rosewood family.

The investigation into Gerald's case leads Rosewood and Villa to Cuba, where they confront two new mysteries; TMI brings her former roommate to help decipher evidence.

A hostage situation erupts at the East Miami Police Department, and Rosewood, Villa and Slade are trapped on the inside. Rosewood forms a strong bond with their captor and must solve his biggest medical mystery to date in order to keep his team alive.

When an escape artist is found dead in a wooden trunk, Rosewood and Villa must unravel a case packed with illusions and deception. Meanwhile, Hornstock's days with the East Miami PD may be numbered and Rosewood gets to know Adrian to make sure he is the right guy for Villa.

Rosie and Villa find themselves caught in the middle of an explosive investigation that makes them question whether justice really is blind. Meanwhile, as the decks are cleared for Rosie and Villa to finally act on their feelings, Rosie stumbles on some information that forces him to embark on his own private investigation behind Villa’s back. What he finds could change their relationship forever. Also, Pippy and TMI are moving closer to their wedding day, Donna’s behavior leads Rosewood and Pippy to suspect she has a new man in her life and an error from Hornstock’s past comes back to haunt him.

Hornstock is a murder suspect when his third ex-wife is killed, so he turns to Rosewood and Villa to help him clear his name.

Rosewood and Villa dive into the hip Miami art scene to catch a serial killer who is on the cusp of creating a "masterpiece." Meanwhile, an impending lawsuit against Rosewood threatens the lifeline of Magic City Lab, and Rosewood tries to protect Villa from his best friend, Mike.

While at an out-of-town forensic pathology convention, Rosewood unintentionally reveals the blueprint to commit the perfect murder during a speech to the convention attendees. Tormented, and armed only with a hunch, Rosewood enlists Villa to help solve the crime, and while investigating undercover, sparks fly unexpectedly between them. Hornstock and Floyd Butters are called upon for extra help. Meanwhile, Pippy and TMI have locked themselves in the lab overnight to help with the investigation and TMI receives an unexpected visit from her estranged father.

When a victim, presumed dead, wakes up on Rosie's autopsy table, the team is thrown into a world in which people go to great lengths to keep their secrets hidden. Both Rosie and Villa are forced to re-examine the meaning of family, and Rosie's search for a Magic City Lab investor leads him to a surprising candidate.

A criminal lures Rosewood to the murder scene of a former tech millionaire and, in doing so, forces Rosie to re-examine a case from his past.

When a female astronaut is found dead, Rosie and Villa launch into an investigation of America's space program. Rosie navigates new dynamics regarding his latest health issue, and Villa's long-lost brother returns to Miami.

Rosewood and Villa investigate the murder of a telenovela star, holding a mirror up to their own relationship as they explore a world of off-screen soap and intrigue. Meanwhile, Erica strong-arms her way into Rosewood's life, much to Donna's chagrin. Then, Rosewood's precious GTO is stolen, and Villa reconnects with her mother, Daisie.

Rosewood and Villa are pulled into the world of human trafficking to investigate the death of a school teacher, and a surprising insight into Slade's past draws Rosie and Villa closer than ever before.

Rosewood and Villa seek justice for a murdered ex-con who had ties to a Little Haiti gang; Villa struggles with her recent dreams; Rosewood faces an unexpected turn in his relationship with Kat.

A bounty hunter who happens to be Hornstock's former partner helps Rosewood and Villa track a murderer; Pippy receives an opportunity that could launch her music career; Villa attempts to reconnect with her mother.

Rosewood’s partnership with Villa faces an uncertain future when she’s paired with a recent transfer to the East Miami PD, with whom she shares a past. As Villa and her new partner investigate the death of a suburban dentist who ran a yuppie drug ring, Rosewood can’t shake the feeling that his “replacement” knows more about the victim’s narcotics business than he’s letting on. Meanwhile, a new medical examiner, Dr. Anita Eubanks, is brought in to help with the investigation and Hornstock’s insecurities hinder his ability to handle the public relations side of the case, forcing him to turn to an unlikely source for help

Rosie insists on celebrating his and Villa's nine-and-a-half month anniversary as partners, which lands them in the middle of a case involving none other than Julius "Joo-Joo" Beeman, their confidential informant. But, this time, Joo-Joo is the prime suspect. As Rosie and Villa work to uncover the truth, even if it means putting Joo-Joo away for life, they discover a whole new side of him they never saw coming. Meanwhile, Villa's choice for her new home has Rosie worried about the new path she's on, Pippy and TMI struggle to balance old friends and family, and Hornstock has trouble reading signals from the new, badass, female chief of police.

Rosewood investigates the suspicious death of a man with medical issues similar to his own, which forces him to slightly adjust the tint on his Rosie-colored lenses and confront his own mortality. Also adding to his stress, he finds himself trapped between Donna and his girlfriend/cardiologist, Dr. Erica Kincaid, and their dueling opinions over what’s best for Rosewood – medically and personally. Meanwhile, Hornstock enlists the help of Villa as he attempts to reconnect with one of the witnesses linked to the case...his estranged teenage daughter, Sophie

When two bodies and lot of cash wash up on the shore of Miami Beach, Rosewood and Villa are forced to work with a rival private pathologist who threatens Rosewood’s contract with the East Miami Police Department. Meanwhile, Daisie moves in with Villa and oversteps her boundaries, while TMI tries to keep up with Pippy and Cassie.

Despite each being at the top of their fields, Villa and Rosewood are stumped when a local musician and king of catchy jingles suddenly keels over in his studio with no discernable cause of death. Meanwhile, Donna enlists Mitchie to investigate Erica’s “missing year”.

When a patient of Erica Kincaid's dies on the table, Rosewood steps in to help solve what turns out to be the murder of an undercover ATF agent. But when Villa connects with a cold case detective, it turns out this case has more angles than they ever imagined.