When an unexpected piece of evidence surfaces in the 305, Rosewood and Villa attempt to solve a serious crime involving a very well-off Miami man. Meanwhile, Rosewood struggles to balance a new romantic interest with the demands of his mother, and Villa runs into trouble on the job.

Set against the vibrant backdrop of one of the world's hottest cities - Miami - private pathologist Dr. Beaumont Rosewood, Jr. must crack a case that hits close to home. As he begins his investigation, Detective Annalise Villa gives him a run for his money as they cross paths and are forced to work together to help the Miami PD solve the case.

Despite each being at the top of their fields, Villa and Rosewood are stumped when a local musician and king of catchy jingles suddenly keels over in his studio with no discernable cause of death. Meanwhile, Donna enlists Mitchie to investigate Erica’s “missing year”.

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Hornstock is a murder suspect when his third ex-wife is killed, so he turns to Rosewood and Villa to help him clear his name.

A bounty hunter who happens to be Hornstock's former partner helps Rosewood and Villa track a murderer; Pippy receives an opportunity that could launch her music career; Villa attempts to reconnect with her mother.

Amidst the glitz and glamour of Miami Fashion Week, there's a plot to kill one of the city's hottest new designers, who turns to Rosewood for help. As the case takes Rosewood and Villa from the catwalk to the perp walk, Rosewood learns of his shared past with the victim. When he enlists the aid of his best friend, Dr. Mike Boyce, Rosewood unintentionally gives Villa the jolt she needs to get back into the dating pool. Potential love also is in the air for Donna, who tries her hand at online dating. Meanwhile, Pippy and TMI find their romance on the skids when Pippy discovers TMI has kept an important secret from her.

While at an out-of-town forensic pathology convention, Rosewood unintentionally reveals the blueprint to commit the perfect murder during a speech to the convention attendees. Tormented, and armed only with a hunch, Rosewood enlists Villa to help solve the crime, and while investigating undercover, sparks fly unexpectedly between them. Hornstock and Floyd Butters are called upon for extra help. Meanwhile, Pippy and TMI have locked themselves in the lab overnight to help with the investigation and TMI receives an unexpected visit from her estranged father.

Rosewood investigates the suspicious death of a man with medical issues similar to his own, which forces him to slightly adjust the tint on his Rosie-colored lenses and confront his own mortality. Also adding to his stress, he finds himself trapped between Donna and his girlfriend/cardiologist, Dr. Erica Kincaid, and their dueling opinions over what’s best for Rosewood – medically and personally. Meanwhile, Hornstock enlists the help of Villa as he attempts to reconnect with one of the witnesses linked to the case...his estranged teenage daughter, Sophie

When a patient of Erica Kincaid's dies on the table, Rosewood steps in to help solve what turns out to be the murder of an undercover ATF agent. But when Villa connects with a cold case detective, it turns out this case has more angles than they ever imagined.

An investigation into the death of a food truck vendor with a crooked history reveals the victim has a connection to Slade's past.

When two bodies and lot of cash wash up on the shore of Miami Beach, Rosewood and Villa are forced to work with a rival private pathologist who threatens Rosewood’s contract with the East Miami Police Department. Meanwhile, Daisie moves in with Villa and oversteps her boundaries, while TMI tries to keep up with Pippy and Cassie.

Rosie and Villa investigate a man who paid in advance for his own autopsy the day before he turned up dead!

An investigation into the death of a Miami model the night after her beachfront photo shoot leads Rosie and Villa into the world of plastic surgery.

A mysterious death in an empty high-rise pulls Rosie and Villa into the inner circle of a former child star who may be planning a comeback. Meanwhile, Rosie is feeling the effects of Donna's involvement at Magic City Lab, and shocking revelations from Hornstock and Rosie elevate their relationship to a new level.

A series of mysterious deaths pulls Rosewood off the glamorous promenades of South Beach when a troubled young genius stands accused of murder, and the only one who believes in his innocence is Rosewood. He must contend with a colorful new adversary, escalating health problems and a burgeoning romantic relationship, while Villa's inability to connect with people hampers her own ability to investigate the case.

Rosewood and Villa must prove a brilliant doctor murdered two patients, despite a limited amount of evidence; Rosewood receives a letter containing potentially life-altering news.

Rosewood and Villa seek justice for a murdered ex-con who had ties to a Little Haiti gang; Villa struggles with her recent dreams; Rosewood faces an unexpected turn in his relationship with Kat.

Hornstock is a murder suspect when his third ex-wife is killed, so he turns to Rosewood and Villa to help him clear his name.

Rosewood and Villa dive into the hip Miami art scene to catch a serial killer who is on the cusp of creating a "masterpiece." Meanwhile, an impending lawsuit against Rosewood threatens the lifeline of Magic City Lab, and Rosewood tries to protect Villa from his best friend, Mike.

A new captain shakes things up at the East Miami Police Department, and Miami's young, hot-shot mayor gets personally involved when his promising young mentee is mysteriously murdered.

When Rosie and Villa discover that their murder victim has a death certificate from three years ago, they’re charged with uncovering the truth around his identity. As they struggle to solve the mystery around his death, as well as around Eddie’s, TMI tries to reconnect with Pippy and Donna finds it hard to keep a secret from her family.

The team is thrown for a loop when the mummified body of a notorious music producer is found on a yacht. Meanwhile, Rosewood is forced to deal with a shocking revelation about Tawnya.

The hunt for a counterfeit currency kingpin allows the team to get a glimpse into Villa's past. Meanwhile, Rosie receives surprising news about his recent health issue.

When a female astronaut is found dead, Rosie and Villa launch into an investigation of America's space program. Rosie navigates new dynamics regarding his latest health issue, and Villa's long-lost brother returns to Miami.