Set against the vibrant backdrop of one of the world's hottest cities - Miami - private pathologist Dr. Beaumont Rosewood, Jr. must crack a case that hits close to home. As he begins his investigation, Detective Annalise Villa gives him a run for his money as they cross paths and are forced to work together to help the Miami PD solve the case.

When an unexpected piece of evidence surfaces in the 305, Rosewood and Villa attempt to solve a serious crime involving a very well-off Miami man. Meanwhile, Rosewood struggles to balance a new romantic interest with the demands of his mother, and Villa runs into trouble on the job.

A series of mysterious deaths pulls Rosewood off the glamorous promenades of South Beach when a troubled young genius stands accused of murder, and the only one who believes in his innocence is Rosewood. He must contend with a colorful new adversary, escalating health problems and a burgeoning romantic relationship, while Villa's inability to connect with people hampers her own ability to investigate the case.

Amidst the glitz and glamour of Miami Fashion Week, there's a plot to kill one of the city's hottest new designers, who turns to Rosewood for help. As the case takes Rosewood and Villa from the catwalk to the perp walk, Rosewood learns of his shared past with the victim. When he enlists the aid of his best friend, Dr. Mike Boyce, Rosewood unintentionally gives Villa the jolt she needs to get back into the dating pool. Potential love also is in the air for Donna, who tries her hand at online dating. Meanwhile, Pippy and TMI find their romance on the skids when Pippy discovers TMI has kept an important secret from her.

Rosewood and Villa must follow a trail of clues left for Rosie, before another victim falls prey. As things heat up between Villa and Mike, Villa escapes by throwing herself deeper into the case, which inevitably pushes her closer to Rosewood. Meanwhile, Donna intervenes when Pippy decides to give TMI’s absentee mother a piece of her mind. Plus, the Chief position is Hornstock’s, if he is willing to pay a stiff price.

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An investigation into the death of a food truck vendor with a crooked history reveals the victim has a connection to Slade's past.

Rosewood and Villa must prove a brilliant doctor murdered two patients, despite a limited amount of evidence; Rosewood receives a letter containing potentially life-altering news.

Hornstock is a murder suspect when his third ex-wife is killed, so he turns to Rosewood and Villa to help him clear his name.

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Rosie and Villa investigate a man who paid in advance for his own autopsy the day before he turned up dead!

Rosewood and Villa seek justice for a murdered ex-con who had ties to a Little Haiti gang; Villa struggles with her recent dreams; Rosewood faces an unexpected turn in his relationship with Kat.

A bounty hunter who happens to be Hornstock's former partner helps Rosewood and Villa track a murderer; Pippy receives an opportunity that could launch her music career; Villa attempts to reconnect with her mother.

Rosewood’s partnership with Villa faces an uncertain future when she’s paired with a recent transfer to the East Miami PD, with whom she shares a past. As Villa and her new partner investigate the death of a suburban dentist who ran a yuppie drug ring, Rosewood can’t shake the feeling that his “replacement” knows more about the victim’s narcotics business than he’s letting on. Meanwhile, a new medical examiner, Dr. Anita Eubanks, is brought in to help with the investigation and Hornstock’s insecurities hinder his ability to handle the public relations side of the case, forcing him to turn to an unlikely source for help

Rosie insists on celebrating his and Villa's nine-and-a-half month anniversary as partners, which lands them in the middle of a case involving none other than Julius "Joo-Joo" Beeman, their confidential informant. But, this time, Joo-Joo is the prime suspect. As Rosie and Villa work to uncover the truth, even if it means putting Joo-Joo away for life, they discover a whole new side of him they never saw coming. Meanwhile, Villa's choice for her new home has Rosie worried about the new path she's on, Pippy and TMI struggle to balance old friends and family, and Hornstock has trouble reading signals from the new, badass, female chief of police.

Rosewood investigates the suspicious death of a man with medical issues similar to his own, which forces him to slightly adjust the tint on his Rosie-colored lenses and confront his own mortality. Also adding to his stress, he finds himself trapped between Donna and his girlfriend/cardiologist, Dr. Erica Kincaid, and their dueling opinions over what’s best for Rosewood – medically and personally. Meanwhile, Hornstock enlists the help of Villa as he attempts to reconnect with one of the witnesses linked to the case...his estranged teenage daughter, Sophie

When two bodies and lot of cash wash up on the shore of Miami Beach, Rosewood and Villa are forced to work with a rival private pathologist who threatens Rosewood’s contract with the East Miami Police Department. Meanwhile, Daisie moves in with Villa and oversteps her boundaries, while TMI tries to keep up with Pippy and Cassie.

Despite each being at the top of their fields, Villa and Rosewood are stumped when a local musician and king of catchy jingles suddenly keels over in his studio with no discernable cause of death. Meanwhile, Donna enlists Mitchie to investigate Erica’s “missing year”.

When a patient of Erica Kincaid's dies on the table, Rosewood steps in to help solve what turns out to be the murder of an undercover ATF agent. But when Villa connects with a cold case detective, it turns out this case has more angles than they ever imagined.

A new captain shakes things up at the East Miami Police Department, and Miami's young, hot-shot mayor gets personally involved when his promising young mentee is mysteriously murdered.

When Rosie and Villa discover that their murder victim has a death certificate from three years ago, they’re charged with uncovering the truth around his identity. As they struggle to solve the mystery around his death, as well as around Eddie’s, TMI tries to reconnect with Pippy and Donna finds it hard to keep a secret from her family.

The team is thrown for a loop when the mummified body of a notorious music producer is found on a yacht. Meanwhile, Rosewood is forced to deal with a shocking revelation about Tawnya.

A mysterious death in an empty high-rise pulls Rosie and Villa into the inner circle of a former child star who may be planning a comeback. Meanwhile, Rosie is feeling the effects of Donna's involvement at Magic City Lab, and shocking revelations from Hornstock and Rosie elevate their relationship to a new level.

The hunt for a counterfeit currency kingpin allows the team to get a glimpse into Villa's past. Meanwhile, Rosie receives surprising news about his recent health issue.

When a female astronaut is found dead, Rosie and Villa launch into an investigation of America's space program. Rosie navigates new dynamics regarding his latest health issue, and Villa's long-lost brother returns to Miami.