Behind the scenes at the chaotic "set" of Sealab 2021. In this episode, the voice actors use their own names rather than the characters'. The episode is a parody of Living in Oblivion by Tom DiCillo.

A series of unexplained thefts leads Murphy to declare "Martian law". In the ensuing madness, everyone ends up blaming Quinn for all the thefts.

After running up thousands of dollars in credit card debt, Murphy can't come up with a way to pay for it all...until Sparks intervenes. He takes out life insurance policies on the crew before sending them on a fatal fool's errand, and proceeds to kill Captain Murphy with a homemade tesla coil in the hot tub. However, Captain Murphy grabs Sparks as he is being electrocuted, killing Sparks as well.

A mysterious Asian visitor brings an irresistibly cute Gloop (reminiscent of shmoos) onto the station, which Murphy names Squishface. There are two problems, though: Gloops stink, and they multiply so fast that eventually Sealab is overrun with them. This episode parodies "The Trouble With Tribbles", Gremlins, and Aliens. There is also a reference to the popular fps shooter Return to Castle Wolfenstien when Debbie calls out "I need ammo!" and a bullet icon appears over her head.

Murphy's golf game is, due to a lack of golfballs, cut short. Murphy embarks on a frantic quest to find the Pro Shop. On the way, Murphy runs into a Monster-Hesh, snotty telephone operators, the Dolphin Boy, and a perfidious Eggers.

The crew of Sealab (along with a vapid gossip-show host, a bear in lederhosen and guest stars Kid 'n Play) star in a sneak preview special for the movie Tinfins, complete with plenty of ads for the restaurant Grizzlebee's: "You'll wish you had less fun".

A nuclear submarine crashes outside the station, and the crew of Sealab (in a rare occurrence) must work quickly to stop an environmental disaster from happening.

Capt. Murphy's attempts at a happy Alvistide go awry thanks to non-Alvian crew members, an uncooperative electrician, and Alvis himself "crapping the buffet".

As Captain Murphy leaves for The Great Spice Wars, a new captain, Tornado Shanks, is given the helm.

The last of Captain Shanks' brothers (who are all named for mythical Greek heroes) dies from a heart attack while taking a dump; all the while, Hesh and Debbie Dupree get married.

Hollywood Actor Beck Bristow (Brian Bloom) comes to Sealab to study for a television role.

Dr. Quinn teaches Debbie Love's class of 4th-graders including Fatass McBlobbicus, while having to deal with Tornado Shanks' warped and unscientific view of education. The classic story "The Scarlet Ibis," by James Hurst, is ripped off as part of a classroom discussion of death. All the while, cuts are made between Debbie Love's classroom and the spa Love is visiting, creating a series of double entendres.

As it turns out Sealab was built on an ancient Indian burial ground and is now sinking into the ocean floor. The only hope to save Sealab is John Bear, Sealab's resident Native American. But in order to save Sealab Shank's must agree to turn the Mess Hall into a casino which he does. But once the casino opens John Bear still won't stop the sinking (or let Debbie have a lounge show).

Marco's illegitimate son applies for a job on Sealab. Can he pass the civil service exam with Debbie and Quinn helping?

The cast looks back over five years of "A Legacy of Laughter" in the style of one of those tacky TV reunion specials but of course since this IS Sealab, not all goes well.

Quinn and Stormy are stuck in a cave with only 10 minutes of oxygen while sealab burns.

Marco died three episodes ago. What's he doing back? Later, Marco and Debbie sing Antônio Carlos Jobim's "Waters of March" in Portuguese.

Abalon, a terminally ill whale, comes to Sealab and asks Doctor Quinn to kill him. While Quinn wonders whether or not he could end a life Stormy recognizes Abalon as the star of a show called ‘I Gotta Have That Dick' and starts bugging him with fan fics. While Quinn examines Abalon's whale cancer Marco accidentally eats some of it and is inspired to create his own drink called F-YEAH!

Debbie and Quinn break up, while Dr. Virjay gets his old rock band back together.

A delivering mishap and some dishonesty on Sparks' part pockets Sealab a brand new Asteroid Smasher/High-definition Television. Unfortunately, the ASHDTV was supposed to go to Spacelab so they could destroy an asteroid hurtling towards the earth.

Quinn, White Debbie, and "He Who Smokes Bitches" Stormy Waters venture deep into Tornado Shanks to destroy a malignant tumor in Captain Shanks' head.

Tornado Shanks declares Sealab a sovereign nation in order to be his own tax haven. A wave of secession fever sweeps through the entire crew, with a half-dozen nations declaring themselves independent in a few minutes; with the help of two British businessmen, they are all soon armed with missiles allegedly loaded with nuclear warheads. When push comes to shove and every Sealab nation declares war on every other one, however, the nukes all turn out to be duds.

Zombies ravage Sealab as Debbie plans her (fifth) 30th birthday party.

Dr. Quinn forcibly takes a well-deserved vacation, inside Sealab's walls, the crew attempts to find out what he's doing.

Captain Murphy opens Sealab to tourists, eventually prompting Dr. Virjay to renounce his religion, and begin to eat meat from cows.