Russell Partridge announces to his wife Janet one day that he is in fact a killer who has murdered his six previous wives, and notifies her that she has one day to live and get her affairs in order before he murders her, too. Janet can get no one to believe her tale, except Holmes and Watson, who must devise a plan to trap the killer before Janet's time runs out.

Sir Charles Farnsworth is found dead in his mysterious Farnsworth Castle. It turns out that Farnsworth had a clause inserted in this will that his death, no matter what the apparent cause, would be investigated by Sherlock Holmes. Holmes' investigation reveals traces of arsenic in the man's body, and there seems to be no shortage of people who knew Sir Charles who wanted him dead.

This is the story of the hunt for the MacGregor treasure -- and curse. The villain would be the castle's foreclosing mortgage holder, Archibald Ross.

The only clue at the site of two grisly murders is a chicken's foot. Baffled, Insp. Lestrade goes to Sherlock Holmes for assistance.

Vaudeville escape artist Harry Crocker turns to Sherlock Holmes for help when he is accused of strangling a chorus girl.

Sherlock Holmes investigates a strange story told to him by a shopkeeper, who claims to have been a member of the 'League of Red-Headed Men' until it unexpectedly dissolved.

A young boy shows up at Baker Street, asking for Holmes' help in finding his missing father. Holmes' investigation reveals that the man is a gambler on the run from his creditors, and the team begins to make the rounds of the seedy gambling underworld in search of the boy's father.

Lady Beryl confesses to a murder that was committed at her home, but Sherlock Holmes is convinced that she is innocent.

Sherlock Holmes helps Scotland Yard to track down a killer who has been leaving three thistles next to each of the women he has murdered.

When a serial killer is sentenced to death, he issues a threat that he will kill Sherlock Holmes before he himself is executed.

A chemist is accused of the murder of his fiancé's stepfather, who was determined to keep the two apart. Although there is mounting evidence of the chemist's guilt, Holmes is requested by the old man's housekeeper to investigate the case, as she believes the young man to be innocent.

When Dr. Watson thinks that he has seen a ghost, it puts Sherlock Holmes on a trail that leads to a crime at an art museum.

Sherlock Holmes seeks a rational explanation for the Winthrop family legend, which foretells the death of any family member who unexpectedly finds silver coins in his possession.

Millicent Channing comes to consult Sherlock Holmes because her fiancé John has disappeared. John has recently been absorbed in his historical study, believing that he has made an important discovery. All that Millicent knows about it is that John was planning to see Sir Thomas Greystone. She tells Holmes about her visit to Greystone Castle, where she was received coldly by the Greystones, and was told that they had never seen John. Holmes proceeds to John's flat to look at his research papers, and he finds a copy of a historical inscription that he then takes with him to Greystone Castle.Millicent Channing comes to consult Sherlock Holmes because her fiancé John has disappeared. John has recently been absorbed in his historical study, believing that he has made an important discovery. All that Millicent knows about it is that John was planning to see Sir Thomas Greystone. She tells Holmes about her visit to Greystone Castle, where she was received coldly by the Greystones, and was told that they had never seen John. Holmes proceeds to John's flat to look at his research papers, and he finds a copy of a historical inscription that he then takes with him to Greystone Castle.

Sherlock Holmes helps one of Dr. Watson's old friends by explaining the source of an odd noise in the man's home, but in doing so Holmes uncovers a more serious mystery.

Dr. John Watson meets private detective Sherlock Holmes, and assists him in solving a case that has confused Inspector Lestrade.

Holmes and Watson travel to Sussex to investigate the murder of Squire Douglas, who was shot to death in a sealed-up castle, with only two apparent suspects.

Sherlock Holmes tracks down a murderer who uses a young girl to lure victims to empty houses, where they are killed.

Holmes and Watson are called to a boy's school in Belgium. It seems that a young student has gotten into the habit of writing the names of faculty members on the steps of a nearby church, and shortly afterwards person whose name has been written down is found dead.

Jessie Hooper hires Holmes to find her missing husband, William, and -- with the help of Lestrade's cousin MacDougal of Glasgow -- he his found hung -- like his grandfather. A rope salesman's laugh is the key clue. It is ironically the window that William never returned to repair that traps villain by his tie.

A condemned man scheduled to hang the next day uses his last request to ask Sherlock Holmes to prove his innocence of the murder for which he is about to be executed.

Dr. Watson urgently fetches Sherlock Holmes from his club, and brings him to see a French interpreter who urgently needs the detective. The interpreter, M. Dubec, explains how his services were requested by a man named Lattimer, who then abducted him and took him to an unknown location. There Dubec was asked to persuade a Frenchman to sign some papers for Lattimer and an associate, so that they can gain control over his sister's wealth. The case becomes more urgent when the criminals find out about Dubec's meeting with Holmes, and once again take him to their hidden location.

"Aunt Lottie", an advice columnist who is actually a man named Alex Doogle, advises a young woman to break up with her violent and insanely jealous boyfriend. The jilted boyfriend then finds Doogle, severely beats him and threatens his life. Doogle turns to Sherlock Holmes, both for his own protection and to save the young woman from her crazed fiancé.

Dr. Watson accidentally comes home from his club with another man's coat, providing an important clue when the other man is murdered late that same night.

Holmes and Watson return from a vacation at Brighton to find an impostor has been impersonating Holmes, misadvising Lestrade to guard Hambleburg's not Carrolton's jewelry store and Sir Arthur to hide his valuables in the biscuit jar. Fighting impersonation with impersonation, Watson becomes the maharaja of Gampoor.