Student Peter Parker is labeled a "bookworm" by his peers when he declines their offer of a triple-date in favor of viewing a radiology experiment.

On his first night at work at the Daily Bugle, Peter overhears talk of a fake medicine racket engineered by a rotund mobster called the Kingpin.

Two robbers dynamite a bank safe and abscond in their car with millions of stolen dollars.

Luck, Suggestion and Determination must guide Spider-Man through this trip into the 5th dimension. Spider-Man finds himself face to face with The Skeletal Infinata.

Sophisticated diamond thief Dr. Cool and his henchman have heisted a fortune in diamonds and are at a deserted-before-dawn ice factory, planning to smuggle the gems through international customs by mixing the "hot ice" with large quantities of the ordinary variety.

Historic villains Blackbeard the Pirate, Jesse James, and the Executioner of Paris are committing robberies in New York City.

Spider-Man's old enemy, the rampaging Rhino, is stealing gold bullion to mold an auric likeness of himself.

Doctor Octopus imposes upon Dr. Smartyr's Nullifier rocket test and steals the ultra-powerful destructor missile.

Reports of a legendary flying ghost ship, the Flying Dutchman, being sighted near Smuggler's Cove summon Spidey to the area, where his investigation into the phantom ship's appearance leads him to a cave in which he finds his sworn adversary, Mysterio, plotting with a pair of thugs.

Spider-Man faces off against Parafino, a wax museum owner who plans to make Spider-Man into his latest exhibit.

Dr. Stillwell creates the Scorpion on J. Jonah Jameson's behalf to capture Spider-Man. The Scorpion attacks Spider-Man, who escapes. However, the Scorpion's evil nature takes over as his strength increases which causes him to go after Jameson.

When a Jekyll-and-Hyde poster comes to life at the soon-to-be-demolished Castle Theatre, Spidey visits the theatre and encounters mischievous Blackwell the Magician, who is trying to attract public attention to the theatre in hope of preventing its demolition.

A bald-headed mastermind, the Plotter, employs two ridiculous criminals, Cowboy and Ox, to steal a blueprint to a missile.

While Blackwell the Magician is entertaining at the Castle Theatre, his house is invaded by the Green Goblin, who swipes some of Blackwell's props and peruses Blackwell's book of magic spells and incantations.

Art robberies are committed by an old enemy of Spider-Man, actor Charles Cameo, who can utilize masks and make-up to usurp any identity, including those of J. Jonah Jameson and Spiderman!

Giant, mechanical beetles are used by Manta to capture and enslave the peace-loving inhabitants of an island to mine a valuable ore.

Dr. Irving Caldwell has devised a helmet capable of levitating its wearer and is kidnaped by a villainous scientist, Dr. Zap, who wants Caldwell's helmet to duplicate for his own evil use.

Spider-Man has been witnessed committing a robbery of the Midtown Museum.

Spider-Man is keeping an eye on a train when the Rhino rams into it and steals the first component of a top secret weapon.

Someone has sent a one-eyed idol to J. Jonah Jameson. Jameson is hypnotized by the idol to steal his own money. Spider-Man finds the thief, but he escapes with the money.

Peter flies to Florida to find and photograph the Lizard Man. Spider-Man meets Dr. Curtis Connor's family. He is pulled underwater by the Lizard Man, but escapes.

Spider-Man attempts to halt the Phantom's activities only to be set up by him and his robot henchwoman Marie, who is disguised as a shop window mannequin.

Spider-Man saves a boat from Dr. Matto Magneto's attempt to crash it on the rocks by sabotaging a lighthouse.

Miss Trubble, a book dealer obsessed with mythology, is owner of a magical chest from which she summons a succession of mythological figures, from centaurs to the Cyclops to Diana the Hunter-Goddess, to commit robberies of ancient artifacts on her behalf.

An inventor named Henry Smythe reveals his plans to capture Spider-Man with a robot and get paid by J. Jonah Jameson for his efforts.