From his vantage point atop a building, Spidey watches as crowds form long lines to attend Saturday night Broadway performances. To the panic of the mass of people, the Moon becomes a psychedelic pinwheel that fills the night sky and dizzies and renders everyone- including Spidey- unconscious.

A scientist, Dr. Noah Boddy, renders himself invisible by means of a machine, then acts to avenge himself upon Jameson, who publically maligned his theory of invisibility.

Jameson orders Peter to fly in an airplane with Daily Bugle pilot Osa Olsen to the North Pole to locate a fallen meteor with bizarre antennae, but a thunder-snowstorm cripples Parker and Olsen's airplane, and it crashes in a wasteland populated by a tribe of savages.

A bolt of lightning breaks Spidey's web, causing him to fall into a boxcar at a rail yard. In the boxcar, Spidey meets a young runaway who plans to ride a freight train out of New York City and become "the Caped Protector of Podunk".

Spidey jousts with a motorcycle-riding knight in armor who is robbing theatre box offices, armored trucks, and museum officials receiving a medieval artifact.

Spidey chases the culprit in an attempted theft of jewels from a countess and is surprised to find that his opponent, dressed in a black Human Fly costume, also has the ability to scale walls and can cross thin wires between buildings.

An old enemy of Spidey's, a radiation specialist who once lifted Manhattan into the sky, has been released from jail and promptly revisits Manhattan's nuclear power plant, stuns the outdoor guards with his ray gun, and again commandeers the reactor.

Mugs Riley, evidently escaped from prison, has duped the Molemen into following him again.

The Kingpin's latest scheme to control New York involves a machine that brainwashes city officials into doing as the commands.

Dr. Curtis Conner goes missing in the Florida swamps after finding the Fountain of Youth. When Spidey investigates the scientist's disappearance, he discovers a fifteenth century Spanish conquistador, Ponce de León, who is intent upon keeping the magical fountain a secret.

When the Scorpion, intent on vengeance upon Spider-Man and Jameson, escapes prison, he visits the laboratory of his creator, Dr. Stillwell, and drinks a potion that vastly increases his size.

Dr. Dumpty, a corpulent jewel thief, attacks a parade with knock-out gas released from balloons, and he and his thugs, wearing gas masks, steal the jewels of actress Rachele Wells and abscond in a hot air balloon.

On Jameson's orders, Peter, and Daily Bugle pilot, Penny Jones travel by small-engine airplane to the Antarctic Ocean to track a fallen nose cone and crash-land on an island with a superstitious, brutish, native population.

New York City children build a snowman with snow contaminated by trace chemicals from an industrial plant up the Hudson River, and a freak accident involving a broken electrical line hitting the snowman somehow brings the snowman to life.

Desperado, a cowboy criminal, lassos Spidey and begins a crime wave atop his electronic horse.

Dr. Vespasian, a green-skinned, wrinkled scientist, concocts a drinkable invisibility formula and uses it on himself and his dog, Brutus.

The weird Dr. Atlantian rises out of the ocean near New York City in his hive-like machine, which derives its power from Lunar motion.

Spider-Man battles an Arabian jewel thief, whose magical flute induces animals into attacking Spidey.

Oil is being stolen in huge quantities by Dr. Von Schlick, a chemist villain garbed in a rubber, non-stick suit and armed with petroleum-based bubbles that he fires from his fingers.

The nefarious Vulture traps Jameson inside of a tower-clock and uses the well-informed Daily Bugle publisher as a source of information on the whereabouts of a visiting diamond merchant and the testing of military equipment—two prospective heists for the greedy bird-man.

Life-like and substantial shadows of beasts are projected in various locations in New York City by the Phantom's new Shadow-Scope glasses to cause panic and enable the Phantom to effect unconstrained bank and jewelry store robberies.

Because he hates rock-and-roll for its having replaced classical music in the tastes of the masses, a fiddler with a deadly, sonic violin seeks revenge upon pop-music sponsor Cyrus Flintridge.

Paroled from prison, the Human Fly Twins rob diamonds from an importing company, and one of them does this deed in a Spider-Man costume so that the guard, before being hit on the head from behind by the second twin, believes that Spidey is the culprit.

Pardo is a sorcerer with the ability to transform himself into a giant cat with hypnotic eyes. He lures top New York City’s citizens and officials to a theatre with the promise of a spectacular show, then releases his feline alter-ego's power upon the hapless audience, intending to divest them of their wealth and sap the souls out of their bodies.

A giant Martian warrior, who throws lightning bolts, comes to Earth to rob the planet of its gold.