Six years in the future, an emotional Captain Archer and the crew return to Earth to face the decommission of Enterprise and signing of the Federation charter.

On a mission to investigate an abandoned Xindi vessel on a jungle planet, Archer, Reed and Hoshi succumb to a virus that mutates them into a primal life form.

The inventor of the transporter, Emory Erickson, comes aboard Enterprise for a risky experiment.

Trip boards an alien cargo vessel to help repair a stasis pod, which holds a beautiful woman in suspended animation. When the woman accidentally wakes up, she reveals she's not a passenger, but a prisoner.

The Enterprise crew alters course to investigate the mystery of Terra Nova, a legendary Earth colony whose inhabitants mysteriously disappeared decades ago. But when they arrive, they confront descendents of the colonists who have become more alien than Archer could ever have imagined.

The Enterprise crew is dispatched by Starfleet Command to assist Fortunate, a human freight vessel that has been attacked by Nausicaan pirates. On arriving, they are surprised to find that Fortunate's crew is resistant to Archer's efforts to help them and determined to seek revenge against their attackers, no matter the repercussions.

While exploring an uncharted planet, Enterprise crew members encounter a group of aliens who are hunting down indigenous creatures for recreation. During their exploration, Archer is mesmerized by visions of an elusive, yet familiar woman who needs his help.

Mayweather discovers his father has died and that things on his old home, the E.C.S. Horizon, have greatly changed.

Archer, Hoshi, Travis, Malcolm and Trip have decidedly different experiences during shore leave on Risa. Meanwhile, on Enterprise, Phlox enters his annual hibernation cycle.

Archer spends a night in sickbay with Dr. Phlox after Porthos contracts a deadly virus on the Kreetassan homeworld. Crew members suspect Archer's increased stress level is due to Porthos' illness, but Dr. Phlox suspects it has to do with Archer's repressed sexual tension.

In need of fuel, the Enterprise arrives at a Quonset mining colony for deuterium supplies. They discover that Klingons are forcing the colonists to give up all their deuterium. Archer and the rest of the crew work to train the colonists so they can fight back against the Klingons.

Archer goes to extreme lengths to save an abandoned nest of Xindi-Insectoid eggs ready to hatch.

A strange, alien creature comes aboard Enterprise, and captures several crew members in its cocoon-like web. With her crewmates' lives in jeopardy, Hoshi faces her biggest challenge yet, in trying to communicate with the lifeform, in order to return it to its home planet.

Religious zealots hijack Enterprise to use it as a weapon against the enemies of their faith.

When Archer and Trip are invited to a desert-like planet by an alien leader, they discover he is a terrorist who has lured them there under false pretences. Meanwhile, T'Pol, while in command, faces a tough decision when she cannot locate Archer and Trip in the desert.

Archer, Mayweather and T'Pol travel to an arctic world to apprehend a fugitive, when T'Pol is contacted by Vulcan High Command. The mission takes a dangerous turn when T'Pol begins having flashbacks that suggest the events she remembers about a former mission may not accurately relate to what happened.

Archer and Tucker are arrested and placed on a prisoner transport heading for a penal colony, Canamar. They won't have a chance to correct this error, as one of the inmates plots a takeover of the ship.

A powerful telepath makes contact with Hoshi and offers to help Enterprise find the Xindi ... for a price.

As a gift for negotiating with the Orion Syndicate, Captain Archer receives three Orion Slave Girls.

Archer sends an away team to a habitable, luscious planet for observation. But when a storm occurs, the team begins to experience paranoid delusions.

Archer and Reed return to a pre-warp society, that is on the verge of war, to recover a lost communicator from an undercover survey mission.

Hoshi experiences her first transporter experience and strange aftereffects lead her to believe she wasn't reassembled correctly.

Noncorporeal aliens possess the bodies of the Enterprise crew.

Archer learns the Klingons have put a price on his head when he is captured by a Tellarite bounty hunter. As Enterprise pursues, a virus causes T'Pol to go into premature Pon Farr.

The NX-01 gets closer to a showdown with the Xindi when Captain Archer takes on an enigmatic passenger: a beautiful slave named Rajiin.