The Cajun Navy is back to fight the war against pythons invading the Everglades. King of the Swamp Troy Landry, along with his son Chase and snake expert Bill Booth, track serpents into a breeding ground known as Deer Haven. Meanwhile, veteran swamper Bruce Mitchell and invasive species hunter, Zak Catchem, take on the legendary Skunk Ape Alley, an area known for strange encounters and massive pythons.

'King of the Swamp' Troy Landry teachers long time alligator hunting partner Pickle Wheat the ins and outs of Python hunting, but sometimes even the most experienced hunter's walk away with scars. Meanwhile, veteran snake hunter Bill Booth and Florida hunter Tes Lee must learn to work as a team if they hope to put a dent in the growing Python population. Zak and newcomer Aaron hunt Pythons in an ancient canal system and almost get in over their heads. Dusty Crum finds the fight for the Everglades knocking at his front door.

Invasive Burmese pythons are taking over the Florida Everglades and devouring everything in sight. The only way to stop them is to call in the nation’s best swampers: King of the Swamp Troy Landry, his son Chase, legendary gator hunter Bruce Mitchell, and big fish wrangler Zak Bagby. Together with professional snake hunter Bill Booth, the men dive into the underbelly of the Everglades to capture and remove the sinister beasts.

One week into the hunt for invasive Burmese pythons, the swampers venture into the foreboding Everglades Triangle. Bruce, Zak and Bill hunt near a mysterious abandoned rocket silo, while Troy and Chase scour a cattle ranch for one of the world’s deadliest snakes: the African Rock Python.

In the third week of fighting monster serpents, hunters face a terrifying reality: the invasion is bigger than they anticipated. With their backs against the wall, Troy, Chase and Bill call upon trackers and thermal drones to get a leg up on the snakes. Meanwhile, Bruce and Zak breakdown in the middle of a swamp that’s rumored to be home to the largest serpent in the world–the green anaconda.

As the hunters face their final week in the Everglades, Troy and Chase protect a remote community from an aggressive gang of alligators. Then, the swampers join forces to track down a deadly hybrid python. Will they be able to stop the rise of the super snakes’

As the hunting season heats up, Troy, Chase and Bill dive into deep water to catch pythons, but might be in over their heads. Meanwhile, Bruce and Zak fear they've bitten off more than they can chew when they venture into Viper Jungle, an area filled with venomous rattlesnakes and moccasins.

The hunters venture into the Everglades Triangle, an area known for mysterious disappearances and swarms of snakes; Troy, Chase and Bill use a drone to search the swamp from the air, while Bruce and Zak track snakes with a handheld thermal device.

When Troy, Chase and Bill mount an airboat to hunt an area pythons are raiding alligator nests, an unfortunate mishap could leave them stranded overnight. Meanwhile, Bruce and Zak's journey into an abandoned ghost town with a haunted past, leads them to an unexpected opportunity.

Troy, Chase, and Bill gamble on a long journey into the center of the Everglades, following the migration of giant pythons to the furthest depths of the wetlands. Meanwhile, Bruce and Zak head deep into outlaw country, looking for snakes hiding on a deserted bootlegging trail...but what they uncover is far more shocking than they expected.

A friendly wager on which team can catch the most snakes and the biggest python; Troy, Bill and Chase return to a honey hole from last season, while Zak and Bruce place their bets on an abandoned Cold War bomb shelter.

As a heat wave grips the Everglades, Bruce and Zak call in canine reinforcements to sniff out serpents hiding from the rising temperature. Meanwhile, Troy, Chase, and Bill hunt the remote jungles of snake island. But when a differing opinion on strategy divides them, Troy soon finds himself alone in the middle of nowhere.

All five hunters converge on the northern edge of the Everglades to stop the invasion of serpents into a critical bird sanctuary.

Pickle must face her fear of big cats as she continues to impress Troy with her natural snake hunting talent. Bill and Tes's hunt stumble on a rumored government testing facility and find all they can handle. Dusty recruits a new hunting partner with a snake phobia while Zak and Aaron battle pythons and the supernatural.

Troy and Pickle hunt a giant python known as the Night Serpent. Tess convinces Bill to try out new hunting grounds, but Bill is not sure it's a good idea. Zak and Aaron explore a notorious corner of the Everglades, and Dusty Crum has an idea to lighten his load.

Troy and Pickle witness how far the pythons have spread; Zak and Aaron take on a new type of beast; Bill and Tess tackle some uninvited guests; Dusty does what he can to prevent an early end to his python season.

Troy and Pickle face a familiar foe while Bill and Tes defend a friend's camp from a slithering invasion; Zak and Aaron's hunt leaves a bad taste in their mouths, and Dusty Crum has a plan to work smarter not harder.

Troy Landry and Pickle Wheat get a tip about a place called the snake pit from a local; Bill and Tes investigate a rock quarry full of pythons; Dusty has a close call with the supernatural, while Zak and Aaron fight to protect the local children.

The battle for the Everglades becomes personal for Troy and Pickle; Bill and Tes venture further north than ever before; Zak and Aaron visit Zak's childhood stomping grounds; Dusty heads to one of his favorite honey holes.

Hunter Bruce Mitchell joins the fight with Zak and Aaron; Troy, Pickle, Bill and Tes team up to help a rancher with a serious problem; Dusty devises a way to light up the night.

Troy and Pickle battle a hyper aggressive breed of python. Bill and Tes try to stay one step ahead of the Army Corp of Engineers. Dusty works on a plan to get the snakes to come to him, while Zak and Bruce face off against two foes.

Troy Landry and Pickle Wheat mix it up with some locals; Tes puts her skills to the test hunting without her partner, Bill; Zak and Bruce return to Viper Alley; Dusty hunts for a legend.

Troy and Pickle track a high-tech snake; Bill and Tes search for a new hot spot; Dusty discovers one of his favourite honey holes has changed forever; Zak and Bruce chase the snakes below ground and get a surprise.

Troy and Pickle help a friend look for his lost dog; Bill and Tes search for pythons in a spot ravaged by wildfires; Zak and Bruce investigate an abandoned boatyard; Dusty hunts in an area with a dark past.

Bill and Tes battle the Everglades heat; Troy and Pickle search for a python paradise; a special day for Dusty goes awry; Zak and Bruce try their luck in the Dead Zone.