Richard must protect his family when he and Lily are discovered to be 4400s.

Tom finds himself in a world where the 4400 never happened.

NOVA group members that were in the custody of NTAC escape from jail with outside help from Jordan Collier. Diana tells April about her relationship with Ben. Shawn and Richard learn that Isabelle is working with Dennis Ryland.

4400 people, assumed to be dead or missing over the past fifty years, reappear in a ball of light. None have any memory of where they've been, and some are manifesting paranormal abilities.

Diana helps Tom break Kyle out of NTAC quarantine, eventually leading them to discover the truth behind the 4400.

Someone is targeting young 4400's and Maia gets kidnapped. A mistake from Shawn's past comes back to haunt him. Richard is given a position of authority at the 4400 Center.

Tom is accused of murdering TJ Kim. 17 year old Boyd Gelder has the ability to change his appearance whenever he chooses. Meanwhile, Shawn and Isabelle grow closer.

Tom and Diana's investigation into a series of gruesome murders leads them to uncover another conspiracy within the government. At the 4400 Center, Shawn receives a gift from another returnee that allows him to see his future.

Tom tracks Jordan to a small town, where he meets a woman who can relieve people's stress by talking to them. Meanwhile, Marco and Diana have a nice talk. Maia's visions are giving her nightmares.

Paramedics try to resuscitate Susan Farrell. They believe that she took promicin and lost the 50/50 lotto that comes with it. Danny is certain that she did not take the shot. After arriving at the hospital with the paramedics, things get complicated as everyone around Danny start to die. Garrity and another NTAC agent are sent to the hospital to assess the situation.

Ryland and other government officials are on trial for withholding vital information that they discovered about the returnees when a disturbing sound is heard the courtroom. Tom and Diana, with the help of Gary Navarro, try and track down T.J Kim, who they believe is responsible for the piercing sound heard in the courtroom. Richard and Lily are forced to deal with a now grown Isabelle While Lily also suffers from a rapid aging disease that Shawn is unable to heal. Tom and Diana also investigate a radical organisation called the Nova Group that appears to have ties with Shawn and the 4400 Center.

Tom and Diana investigate a 4400 who has used his ability of enhanced reflexes to become a vigilante.

A returnee exhibiting telepathic abilities seeks help from NTAC, but is instead used as a mole to infiltrate Jordan Collier's 4400 Center.

Tom and Diana investigate a 4400 whose ability to increase the human bodies' metabolism just may be this weight-conscious world's answer to the ultimate fat-burner.

Tom and Diana investigate a 4400 junior high school teacher accused of child abuse.

A morbid premonition from Maia threatens the future of the 4400 Center.

A 4400 with the ability to repair damaged chromosomes hides a shocking past. And while Richard seeks out a tormentor among his Korean War buddies, Shawn reconnects with his family and tries to help Kyle.

NTAC is keen to find Jordan Collier's killer as Tom is desperate to find Kyle.

A 4400 terrorist releases a signal at NTAC that makes the men violent, forcing a lockdown of the facility. Lilly questions how the Centre is handling her daughter, and Shawn tries to recruit a familiar face.

When 4400s around the world come down with life-threatening illnesses, Ryland comes back to NTAC and orders the sick - and even unaffected 4400s - to be quarantined. Tom and Diana race to find a cure and discover a shocking secret in the process.

Audrey Parker, an elderly woman, takes promicin and develops the ability to astral project. Meanwhile, Shawn decides to start publicly healing people again despite threats from the government to shut him down. And Ben and Maia return to Seattle to visit Diana.

Jordan wants Shawn to rejoin the movement. Meanwhile, a 4400 with an amazing ability disappears.

Tom, Diana, Jordan, Shawn, Kyle, Isabelle, Maia, Meghan, Marco, PJ and Brady all wake up inside NTAC without any memory of how they got there.

Richard surprises Isabelle when he shows up in Promise City but the happy reunion takes a turn when Richard kidnaps her in hopes to start a new life with his daughter.

Tom and Diana investigate Oliver Knox, a 4400 suspected of being a serial murderer.